Clinical trials: Positive End-expiratory Pressure (PEEP)
One-Lung Ventilation
Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery
One-lung ventilation (OLV) with resting of the contralateral lung may be required to allow or facilitate thoracic surgery. However, OLV can result in severe hypoxemia, requiring a mechanical ventilation approach that is able to…
- Trial name
- NCT02963025
- Testing
- PEEP level, Use of recruitment maneuvers
- Where
- 79 sites in United States, Albania and 27 more
- Volunteers
- 2,200 people
- Sponsor
- Technische Universität Dresden
Pneumoperitoneum, Trendelenburg Position
End-expiratory Pressure During Laparoscopic Surgery in the Trendelenburg Position by Electrical Impedance Tomography
Pneumoperitoneum (PNP) and the position of the patient required for laparoscopic surgery lead to pathophysiological changes that complicate anesthesia.
- Conditions
- Pneumoperitoneum, Trendelenburg Position, Laparoscopic Surgery
- Trial name
- CP-EIT (NCT06481124)
- Testing
- electrical impedance tomography
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Respiratory Distress Syndrome
Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)
ARDS (Acute Respiratory Distress Syndrome) is a condition of severe inflammation and excess fluids in the lungs that impairs their function of oxygen uptake to the point of needing a ventilator (breathing machine) to help them…
- Trial name
- NCT00446706
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Traumatic Brain Injury, Mechanical Ventilation Complication
Effects of Positive End-expiratory Pressure on Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The impact of PEEP on ICP was dependent on the difference between elevated CVP levels and baseline ICP levels. ICP would increase once elevated CVP through PEEP adjustment exceeds the baseline ICP.
- Trial name
- PEEP，ICP，CVP (NCT03296293)
- Testing
- PEEP at 5cmH2O, PEEP at 10cmH2O, PEEP at 15cmH2O
- Volunteers
- 38 people
- Sponsor
- Hongpeng Li
Laparoscopic Cholecystectomy
10cmH2O Peep Application and Cerebral Oxygenation in Laparoscopic Surgery: a Comparative Study With Invos and Foresight Devices
In this study the investigators investigated changes in hemodynamic parameters and cerebral oxygen saturation (rSO2) associated with 10 cmH2O PEEP, which is assumed beneficial for the respiratory functions and oxygenation during…
- Trial name
- NIRS AND PEEP (NCT02071550)
- Testing
- FORESİGHT cerebral oxygen monitor and INVOS cerebral oxygen monitor, FORESIGHT and INVOS monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Turkiye Yuksek Ihtisas Education and Research Hospital
Postoperative Atelectasis
Effect of Intraoperative Dynamic Compliance Guided Individualized Positive End-expiratory Pressure on Postoperative Atelectasis After Laparoscopic Bariatric Surgery
This study intends to explore the effect of dynamic compliance guided individualized positive end-expiratory pressure titration strategy on reducing the level of postoperative atelectasis in obese patient who have laparoscopic…
- Trial name
- NCT04169607
- Testing
- Dynamic compliance guided individualized positive end-expiratory pressure titration strategy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuzhou Medical University
PreTerm Neonate, Positive End Expiratory Pressure (PEEP)
PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed.
- Conditions
- PreTerm Neonate, Positive End Expiratory Pressure (PEEP), Lung Recruitment, Electrical Impedance Tomography (EIT)
- Trial name
- [PEOPLE] (NCT06705257)
- Testing
- Studying the effects of varying levels of PEEP using Electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Atelectasis, Postoperative
Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary…
- Trial name
- NCT07432477
- Testing
- Single Step Lung Recruitment Maneuver, Stepwise Lung Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ondokuz Mayıs University
Ventilator-free Days
REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS
The 'REstricted versus Liberal positive end-expiratory pressure in patients without Acute respiratory distress syndrome' (RELAx) trial is a national multicenter, open randomized controlled trial in ICU patients without ARDS at…
- Trial name
- RELAx (NCT03167580)
- Testing
- restricted PEEP, liberal PEEP
- Where
- 13 sites in Netherlands
- Volunteers
- 980 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Laparoscopy, Positive End Expiratory Pressure (PEEP)
Effects of Different Peep Applications on Tissue Oxygenation, Respiratory Mechanics and Postoperative Pulmonary Complications in Laparoscopic Hysterectomy Operations
This study aims to compare the effects of two different PEEP levels (5 cmH₂O and 10 cmH₂O) during laparoscopic hysterectomy on perioperative tissue and cerebral oxygenation, respiratory mechanics, and postoperative pulmonary…
- Conditions
- Laparoscopy, Positive End Expiratory Pressure (PEEP), Respiratory Mechanics
- Trial name
- NCT07105293
- Testing
- PEEP 5 cmH2o applied group, PEEP 10 cmH2o applied group
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Positive End-expiratory Pressure (PEEP), Oxygenation Index
Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation
The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric…
- Conditions
- Positive End-expiratory Pressure (PEEP), Oxygenation Index, Pediatric Intensive Care Unit, Pediatric Acute Lung Injury
- Trial name
- NCT07233304
- Testing
- Alveolar Opening Maneuver and PEEP Titration (AOM+P)
- Where
- Argentina
- Volunteers
- 143 people
- Sponsor
- Hospital de Alta Complejidad en Red
Postoperative Pulmonary Complications, Thoracic Surgery
Intermittent Positive Pressure Breathing Versus Incentive Spirometry After Thoracic Surgery
This randomized controlled pilot study will compare intermittent positive pressure breathing (IPPB) with incentive spirometry (IS) in adult patients undergoing thoracic surgery.
- Trial name
- NCT07867548
- Testing
- Intermittent Positive Pressure Breathing, Incentive Spirometry
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Diaphragm Disease
Effect PEEP on Diaphragm
This study evaluates the effect of positive end-expiratory pressure on the position, length and function of the diaphragm. During the first part of the study, physiological measurements of the diaphragm will be performed while…
- Trial name
- NCT03539640
- Testing
- PEEP: 5 cmH2O, PEEP: 10 cmH2O, PEEP: 15 cmH2O
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Ventilation Therapy; Complications
Optimal PEEP in Pediatric Patients Under 17 Years of Age.
This study aimed to investigate the differences in positive end-expiratory pressure titration in the supine and prone positions by age in pediatric patients under 17 years of age who received general anesthesia and then evaluate…
- Trial name
- NCT05726877
- Testing
- ventilation strategy
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Seoul National University Hospital
Lung Collapse
OLA to Lowest DP in Cardiac Surgery
This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5…
- Trial name
- NCT03133754
- Testing
- DP-PEEP, RM-5
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Community-acquired Pneumonia, Acute Respiratory Distress Syndrome
Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia
Randomized Controlled Trial Comparing Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia. The control strategy will be based on ARDSNet approach.
- Trial name
- STAMINA (NCT04972318)
- Testing
- Positive end-expiratory pressure titration with driving pressure control, ARDSNet ventilatory strategy
- Where
- 6 sites in Brazil
- Volunteers
- 214 people
- Sponsor
- Hospital do Coracao
Lung Transplant; Complications, Primary Graft Dysfunction
Identifying Optimal PEEP After Lung Transplantation
Lung Transplantation (LuTX) is the curative treatment for selected patients with end-stage lung disease. Primary Graft Dysfunction (PGD), a specific form of respiratory failure occurring within the first 72 hours after graft…
- Trial name
- PEEP-LuTX (NCT05691205)
- Testing
- PEEP
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Policlinico Hospital
Acute Hypoxemic Respiratory Failure, Obesity
Adiposity Distribution in Acute Respiratory Failure
Acute Hypoxemic Respiratory Failure (AHRF) is a condition in which injury to the lungs impairs the ability of the air sacs (alveoli) to ventilate and exchange oxygen.
- Trial name
- NCT07019987
- Testing
- PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Maurizio F. Cereda, MD
Mechanical Ventilation Complication
Lung-protective Mechanical Ventilation for Abdominal Laparoscopic Surgeries
This was a double-blind, randomized controlled clinical trial. 62 patients were randomly assigned to receive either lung-protective ventilation (LPV) with a tidal volume (Vt) of 7 ml/kg ideal body weight (IBW), 10 cmH2O positive…
- Trial name
- NCT04546932
- Testing
- Lung-protective mechanical ventilation
- Where
- Vietnam
- Volunteers
- 62 people
- Sponsor
- Vietnam Military Medical University
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas