Clinical trials: Positron-Emission Tomography
Solid Tumor
CD147 Targeting Nanobody Probe for PET Imaging in Solid Tumors
The objective of the study is to construct a noninvasive approach using 68Ga-NOTA-MAL-NB147 PET/CT to detect the CD147 expression of tumor lesions in patients with Solid tumors and to identify patients benefiting from CD147…
- Trial name
- NCT06646952
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hua Zhu
Migraine Without Aura
Investigation of Serotonin Receptor Binding in the Migraine Brain Using Positron Emission Tomography
Migraine affects 16% of the world population and is one of the most disabling of all disorders. It is a complex brain disorder characterized primarily by recurrent headache attacks.
- Trial name
- NCT02309606
- Testing
- PET scan with 5-HT receptor ligands
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Prostate Cancer, Prostate Adenocarcinoma
Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer
This study evaluates the diagnostic performance and safety of 18F-DCFPyL (PyL) PET/CT imaging in patients with suspected recurrence of prostate cancer who have negative or equivocal findings on conventional imaging.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Recurrent, Prostate Cancer Metastatic
- Trial name
- CONDOR (NCT03739684)
- Testing
- 18F-DCFPyL, PET/CT Imaging
- Where
- 14 sites in United States, Canada
- Volunteers
- 208 people
- Sponsor
- Progenics Pharmaceuticals, Inc.
Alzheimer Disease, Parkinson Disease
Evaluation of [18F] FEPPA and PET Imaging as a Marker of Inflammation in Subjects With Neurological Conditions
Ultimately a marker of microglial activation could be used for large-scale quantitative brain imaging trials in Alzheimer Disease (AD), Parkinson Disease (PD) or Multiple Sclerosis (MS), specifically to investigate the agent as…
- Conditions
- Alzheimer Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- NCT00970333
- Testing
- [18F]-FEPPA
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Institute for Neurodegenerative Disorders
Healthy
Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers
To establish the extent to which BIIB014, following 8 to 12 consecutive days of dosing at selected dose levels, occupies the brain's A2A receptors. Receptor occupancy will be assessed by PET scanning using a radiolabelled tracer.
- Trial name
- NCT00531193
- Testing
- BIIB014, [11C]SCH442416
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Biogen
Prostate Cancer, Metastatic Castration-resistant Prostate Cancer
PET Imaging Study of 89Zr-DFO-YS5 in Men With Prostate Cancer
CD46 is an exciting new therapeutic target in prostate cancer, with the antibody drug conjugate FOR46 under investigation in phase I clinical trials.
- Trial name
- NCT05245006
- Testing
- 89Zr-DFO-YS5, YS5 antibody, Positron Emission Tomography (PET)/Computerized tomography (CT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Robert Flavell, MD, PhD
Prostate Neoplasm
F-18 Sodium Fluoride in Prostate Cancer
Background: Sodium fluoride (NaF) is a common compound that is found in various foods and can be used to increase bone strength.
- Trial name
- NCT01240551
- Testing
- F-18 NaF
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Amyloidosis
A Study to Evaluate Organ Level Uptake Repeatability of 124I AT-01 in Subjects With Systemic Amyloidosis
This study is designed to assess the repeatability of organ-specific quantitation of radiotracer uptake following Positron Emission Tomography/Computed Tomography (PET/CT) imaging of AT- 01 in subjects with amyloid light chain…
- Trial name
- AT01-001 (NCT05235269)
- Testing
- 124I-AT-01
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Attralus, Inc.
Parkinson Disease
Imaging the Vesicular Acetylcholine Transporter Using 18F-FEOBV PET in Parkinsons Disease
Patients with Parkinson's disease (PD) often display symptoms, such as constipation, due to denervation of the cholinergic nerves in the gut. It has been hypothesized that PD initiates in the gut years prior to diagnosis.
- Trial name
- NCT03554551
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Smoking, Cigarette, Smoking E-cigarette
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called [18F]NOS.
- Conditions
- Smoking, Cigarette, Smoking E-cigarette, Healthy Volunteer
- Trial name
- NCT03721822
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prostate Cancer
A Clinical Study of [68Ga]Ga-ELI421 Injection PET Imaging in Patients With Prostate Cancer
Primary Objective: To evaluate the safety and tolerability of PET imaging following a single intravenous infusion of [⁶⁸Ga]Ga-ELI421 injection in patients with prostate cancer.
- Trial name
- NCT07689656
- Testing
- [68Ga]Ga-ELI421 injection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Brain Metastases, Adult
Comparaison Between MRI Alone or Combined With Positron Emission Tomography for Brain Metastasis Diagnosis
During gamma scalpel treatment of brain tumors and metastases, a follow-up magnetic resonance imaging (MRI) scan is performed. The radiologist who reviews the MRI assesses whether there is an increase in signal at the tumor site.
- Trial name
- ITIRR (NCT05095766)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Diffuse Large B-cell-lymphoma, Classical Hodgkin Lymphoma
Prospective Comparison Between FDG-PET/MR and FDG-PET/CT in Classical Hodgkin Lymphoma and DLBC Non-Hodgkin Lymphoma
According to the most recent guidelines, total-body imaging techniques are an indispensable element in the staging and post-treatment re-evaluation in patients with lymphoma.
- Trial name
- NCT03042247
- Testing
- FDG PET/TC and FDG PET/MRI
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Marco Picardi
Hodgkin Lymphoma
Early Chemotherapy Intensification in Interim-Positron Emission Tomography (PET) Positive Hodgkin Lymphoma
Early interim-PET after two courses of chemotherapy is a powerful outcome predictor in advanced-stage Hodgkin Lymphoma (HL) patients treated with adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine (ABVD).
- Trial name
- NCT00877747
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Ospedale Santa Croce-Carle Cuneo
Hot Flashes
Study of PET Scans and Serotonin in Hot Flashes Treatment
The purpose of this study is to determine in a preliminary manner whether successful therapy of hot flashes can be associated with changes in the serotonin transporter in the brain.
- Trial name
- NCT00249847
- Testing
- Paroxetine controlled-release, Conjugated equine estrogen
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Endometriosis, Deep Infiltrating Endometriosis
Prospective Trial of [18F]AlF-FAPI-74 for PET Imaging of Fibroblast Activation Protein in Patients With Endometriosis
The goal of this clinical trial is to learn whether [18F]AlF-FAPI-74 PET/CT can help detect endometriosis in adult women who are already scheduled for laparoscopy due to suspicion of deep infiltrating endometriosis or superficial…
- Conditions
- Endometriosis, Deep Infiltrating Endometriosis, Women, Superficial Peritoneal Endometriosis
- Trial name
- EM-FAPI (NCT07876648)
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Multiple Myeloma, Plasmacytoma
S0340 MRI and Fludeoxyglucose F18 PET in Diagnosing Solitary Plasmacytoma
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging (MRI) and fludeoxyglucose F 18 positron emission tomography (^18FDG-PET) may help diagnose solitary plasmacytoma.
- Trial name
- NCT00109889
- Testing
- magnetic resonance imaging, positron emission tomography
- Where
- 26 sites in United States
- Volunteers
- 2 people
- Sponsor
- SWOG Cancer Research Network
Cognitive Dysfunction
Flutemetamol F 18 Injection Formulation Comparison
VIZAMYL (flutemetamol F 18 injection) is a drug used during Positron Emission Tomography (PET) brain scans. It helps doctors detect the presence of amyloid protein, which is associated with Alzheimer's disease and other…
- Trial name
- NCT07873463
- Testing
- GE-287, Vizamyl
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- GE Healthcare
Menopause
Health, Imaging, and Cognition Across the Menopausal Transition
This observational cross-sectional study aims to better understand how the menopausal transition affects brain energy metabolism and cognition.
- Trial name
- MOSAIC (NCT07021664)
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Congenital Hyperinsulinism
18FluoroLDOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism
The goal of this project is to determine the role of FDOPA/PET as a pre-operative diagnostic imaging procedure for differentiating focal and diffuse forms of congenital hyperinsulinism and locating focal lesions in the pancreas…
- Trial name
- DOPA PET (NCT04205604)
- Testing
- 18F-Fluoro Dopa Imaging
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Miguel Pampaloni
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