Clinical trials: Positron-Emission Tomography
Disorder of Consciousness, Traumatic Brain Injury
Changes in Glutamatergic Neurotransmission of Severe TBI Patients
Studies in patients with disorders of consciousness (DOC) after severe brain injury implicate dysfunction of the anterior forebrain mesocircuit dysfunction a key underlying mechanism.
- Trial name
- NCT04244058
- Testing
- Amantadine + L-DOPA, NMDA blocker
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Breast Cancer Stage II, Breast Cancer Stage III
Positron Emission Tomograph(PET) Imaging Explores the Role of SF-DEVD-2 in Monitoring Tumor Efficacy
This is a single arm study to determining the value of apoptotic molecular probe SF-DEVD-2 in the early evaluation of tumor efficacy and comparing it head-to-head wihe 18F-FDG(18F-2-fluoro-2-deoxy-D-glucose)
- Conditions
- Breast Cancer Stage II, Breast Cancer Stage III, Solid Tumor
- Trial name
- NCT05828238
- Testing
- [18F]SF-DEVD-2, [18F]-FDG
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Affiliated Hospital of Jiangnan University
METASTATIC BREAST CANCER
Imaging of in Vivo Sigma-2 Receptor Expression With 18F-ISO-1 Positron Emission Tomography in Metastatic Breast Cancer
Pilot study using [18F]ISO-1 PET/CT to image sigma-2 receptor binding in metastatic breast cancer. Correlate baseline uptake and change in uptake after therapy with time to progression and standard and experimental pathology…
- Trial name
- NCT03057743
- Testing
- Positron emission tomography (PET/CT) imaging, radiotracer [18F]ISO-1
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung Cancer
Stereotactic Body Radiation Therapy in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue.
- Trial name
- NCT00471835
- Testing
- computed tomography, positron emission tomography, stereotactic body radiation therapy
- Sponsor
- Wake Forest University Health Sciences
Prostate Cancer
PSMA Specific [68Ga]-P137 Peptide Probe for PET Imaging in Prostate Cancer
To study the radioactive uptake of [68Ga]P137 in the lesion sites of PCa patients and evaluate the ability of [68Ga]P137 to detect PSMA overexpression in PCa patients (especially those with recurrent or advanced PCa).
- Trial name
- NCT04560725
- Testing
- 11C-Choline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Cancer Hospital & Institute
CNS Lymphoma
[68Ga]Ga-PentixaFor PET Imaging in CNS Lymphoma Patients
This will be an open, single-arm, international, multicentre, phase II imaging study to assess the predictive value of [68Ga]Ga PentixaFor PET imaging in primary and isolated secondary central nervous system lymphoma (CNSL)…
- Trial name
- NCT05222269
- Testing
- 68Ga-PTF
- Where
- 2 sites in Denmark, France
- Volunteers
- 1 people
- Sponsor
- Pentixapharm AG
Atherosclerosis, Coronary Artery Disease
Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease
In this study, multimodal imaging of atherosclerosis and dosage of new circulating biomarkers will be used to compare patients with stable or unstable coronary artery disease
- Conditions
- Atherosclerosis, Coronary Artery Disease, Acute Coronary Syndrome
- Trial name
- BIOCORE-2 (NCT01186666)
- Testing
- Coronary intervention using IVUS-VH & FDG PET-MDCT
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
Background: PDE4D is a protein in the body that plays a role in thinking and depression. This protein may play a major role in disorders such as Alzheimer disease or major depressive disorder.
- Trial name
- NCT06874205
- Testing
- 11C-JMJ-129
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Neuropathic Pain
A Feasibility Study to Investigate the Dynamic Brain Imaging in Patients Following SCS- DRG
Targeted SCS is a standard and safe interventional pain procedure that is offered to patients with intractable neuropathic pain for their symptomatic relief.
- Trial name
- NCT04508127
- Testing
- Spinal cord stimulation
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Bladder Cancer
Positron Emission Tomography (PET) Study for Staging of Muscle Invasive Bladder Cancer
This prospective pilot study will enroll 30 patients with cT2/T3-N0-M0 urothelial carcinoma of the bladder for whom radical cystectomy with pelvic lymph node dissection is planned.
- Trial name
- NCT01655745
- Testing
- FDG PET/MR
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Parkinson Disease, Depression
The Therapeutic Effect of Transcranial Direct Current Stimulation on Depression in Parkinson's Disease
Parkinson's disease (PD) is one of the most common neurological diseases manifested by movement disturbance. The concomitant psychiatric symptoms, especially depression, are often observed and have also great impact on patients'…
- Trial name
- Parkinson's (NCT02917122)
- Testing
- active tDCS, Sertraline
- Volunteers
- 15 people
- Sponsor
- National Cheng-Kung University Hospital
Defibrillators, Implantable
PET / CT With 18F-FDG: Does it Optimize the I 123-MIBG Imaging Results in the Search for Discriminating Factors for the Implementation of an Implantable Defibrillator?
The main objective of this study is to determine among the patients included a subpopulation that does not need a defibrillator.
- Trial name
- NCT01258283
- Testing
- Addional imaging
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Huntington's Disease
[PETDE10] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET.
The aim of this study is to measure the availability of the PDE10A enzyme in Huntington disease gene expansion carriers (HDGECs) using the recently developed radioligand [18F]MNI-659.
- Trial name
- PEARL-HD (NCT02061722)
- Testing
- PET Imaging with [18F]MNI-659
- Where
- 8 sites in Denmark, Netherlands and 2 more
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Liver Cancer, Liver Neoplasm
Integrated Imaging Strategy to Phenotype Progression of Liver Tumors During and After Chemoembolization
Background: Treatment for liver cancer can include surgery, transplant, and chemotherapy. It can also include other minimally invasive tumor treatments such as transarterial chemoembolization (TACE).
- Conditions
- Liver Cancer, Liver Neoplasm, Hepatocellular Carcinoma, HCC
- Trial name
- NCT02471313
- Testing
- [18F] FMISO
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Carcinoma of Unknown Primary, Head and Neck Cancer
PET Scans and CT Scans in Patients With Locally Advanced Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy
RATIONALE: Imaging procedures, such as PET scan and CT scan, may help doctors predict a patient's response to treatment and plan the best treatment.
- Trial name
- NCT00388024
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Artery Disease
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI
The purpose of this study is to see whether apadenoson is as effective as adenosine when used as a pharmacological stress agent in myocardial SPECT-Imaging to detect defects in the supply of blood to the heart muscle (myocardial…
- Trial name
- ASPECT (NCT00990327)
- Testing
- Apadenoson SPECT-MPI, Adenosine SPECT-MPI
- Where
- 122 sites in United States, Brazil
- Volunteers
- 863 people
- Sponsor
- Forest Laboratories
Amyotrophic Lateral Sclerosis, Bulbar Disease
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis
PET imaging of activated microglia offers a tool of investigation of a range of brain diseases where neuroinflammation is a component. Amyotrophic lateral sclerosis is the most frequent motoneuronal disease in adult.
- Conditions
- Amyotrophic Lateral Sclerosis, Bulbar Disease, Spinal Disease
- Trial name
- NCT00563537
- Testing
- 18F-X PET SCAN
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Solid Tumor
A PET Imaging Agent to Assess the Level of Tumor Tissue-infiltrating CD8 + T Cells in Patients With Solid Tumors
Primary objective To investigate the safety and tolerability profile of 68Ga- NODAGA-SNA006 in patients with solid tumors; To investigate the radiation absorbed dose characteristics of 68Ga-NODAGA-SNA006 in patients with solid…
- Trial name
- NCT05126927
- Testing
- 68Ga-NODAGA-SNA006
- Where
- China
- Volunteers
- 11 people
- Sponsor
- SmartNuclide Biopharma
Traumatic Brain Injury
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI
Deficits in memory, attention, cognitive, and executive functions are the most common disabilities after traumatic brain injury (TBI).
- Trial name
- NCT02148783
- Testing
- methylphenidate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Uniformed Services University of the Health Sciences
Dementia, Alzheimers Disease
Assessment of Foralumab Safety and Modulation of Microglial Activation in Alzheimer's Disease
This phase 2a study will research the safety and tolerability of Foralumab, a human anti-CD3 antibody. An antibody is a molecule secreted by the immune system. These molecules are created to identify a specific pathogen.
- Conditions
- Dementia, Alzheimers Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
- Trial name
- NCT06489548
- Testing
- Foralumab TZLS-401 50 µg, Foralumab TZLS-401 100 µg
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
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