Clinical trials: Positron-Emission Tomography
MSA
Establishing 18F-PBR06 PET Imaging as a Viable Pharmacodynamic Endpoint in MSA
The specific aims of the study are: Primary: To determine the presence and regional distribution of microglial activation, as assessed by [F-18]PBR06 PET, in subjects with MSA as compared to healthy controls, at baseline and at 9…
- Trial name
- NCT03033680
- Testing
- [F-18]PBR06
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Heart Diseases, Ischemic
PET-MR Imaging of Coronary Atherothrombosis
Heart attacks remain a common cause of death throughout the world. The most common initiating event is the formation of a blood clot within the coronary arteries occluding blood supply to the heart.
- Trial name
- NCT03618303
- Testing
- PET-MRI scan
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Edinburgh
Alzheimer's Disease
Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants
This is a longitudinal, follow-up study in participants with Alzheimer's disease (AD) who previously participated in study BP29409 (NCT02187627).
- Trial name
- NCT02792179
- Testing
- [18F]RO6958948
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Hoffmann-La Roche
Large-Artery Atherosclerosis (Embolus/Thrombosis)
18F-S2P PET Imaging in the Evaluation of Large Artery Atherosclerosis
The aim of this study is to evaluate the lesion detection performance and safety of 18F-S2P positron emission tomography (PET) in patients with large-artery atherosclerosis.
- Trial name
- NCT07815860
- Testing
- 18F-S2P
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Prostate Cancer
Copper-64 SAR Bombesin in PSMA Negative Prostate Cancer (BOP)
This phase 2a study will involve enrolment of men presenting with progression of biopsy proven prostate cancer who require imaging for staging/re-staging of their disease.
- Trial name
- BOP (NCT05613842)
- Testing
- Copper-64 labelled SAR-Bombesin
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- St Vincent's Hospital, Sydney
Infiltrating Ductal Carcinoma
Contribution of 18FDG PET-Scan in Tumour Volume Determination in Patients Operated of Breast Cancer
Use of positron emission tomography (PET) in determination of functional tumour volume can provide usable information for radiotherapy to define the irradiated volume.
- Trial name
- VOSETEP (NCT01621529)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Alzheimer's Disease
Amyloid-beta PET Imaging With 18F-92 in Alzheimer's Disease
Alzheimer's disease is a neurodegenerative disease. Numerous studies have reported that β-amyloid (Aβ) is an important marker for the diagnosis of AD.
- Trial name
- NCT04926272
- Testing
- 18F-92
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Arterial Stiffness
Relationship Between Aortic Parietal Inflammation on 18F-FDG PET Scan and Arterial Stiffness as a Function of Age
Show that there is a relationship between arterial stiffness and aortic parietal inflammation and that this relationship is different in the three age groups with aortic parietal inflammation occurring earlier than arterial…
- Trial name
- RAIPAo (NCT06151054)
- Testing
- Measure of aortic inflammation
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Central Hospital, Nancy, France
Lymphoma
PET Study in Patients With Non-Hodgkin Lymphoma
RATIONALE: Diagnostic procedures, such as fluorine 18-fludeoxyglucose positron emission tomography (PET) scans, may help doctors predict a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00712556
- Testing
- fluorine 18-fludeoxyglucose positron emission tomography
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Traumatic Brain Injury
Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study
Excitatory amino acids may be involved in secondary neuronal damage after traumatic brain injury. The amount of microglia activation is an indirect measure of neuronal damage.
- Trial name
- NCT00205582
- Testing
- Positron Emission Tomography
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Substance-related Discorder
Effects of Smoking on Opioid Receptor Binding: A PET Study
Background: Tobacco smoking is one of the most preventable causes of morbidity and mortality in the world, but the addictive property of nicotine is such that fewer than 10 percent of people who attempt to quit smoking remain…
- Trial name
- NCT00618631
- Testing
- Nicotine, Carfentanil
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Infantile Spasms
Evaluation of Neuroinflammation in Children With Infantile Spasms
The purpose of this study was to investigate the presence of neuroinflammation in children with infantile spasms using 11C-PK11195 positron emission tomography (PK PET) scan, and its response to ACTH treatment by repeating the PK…
- Trial name
- NCT02092883
- Testing
- ACTH
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wayne State University
Neuroendocrine Tumors
An Imaging Study of 64Cu-SARTATE Using Positron Emission Tomography in Patients With Neuroendocrine Tumours
The primary purpose of this study is to examine the safety and potential effectiveness of a drug molecule called 64Cu-SARTATE as a potential new way to detect neuroendocrine cancers.
- Trial name
- NCT04440956
- Testing
- 64Cu-SARTATE
- Volunteers
- 10 people
- Sponsor
- Clarity Pharmaceuticals Ltd
Alzheimer Disease
Evaluation of [18F] PBR111 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
The underlying goal of this study is to assess PBR-111 positron emission tomography (PET) imaging as a tool to detect microglial activation in the brain of Alzheimer disease (AD) research participants and age- and gender-matched…
- Trial name
- PBR111 (NCT01209156)
- Testing
- [18F] PBR111
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Brain Metastases, Brain Metastases, Adult
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
This is a pilot imaging study in participants treated with stereotactic radiosurgery (SRS) to treat brain metastasis. The purpose of this study is to see whether 18F-Fluciclovine positron emission tomography (PET) can be used as…
- Conditions
- Brain Metastases, Brain Metastases, Adult, Brain Cancer
- Trial name
- FACILITATE (NCT06048094)
- Testing
- 18F fluciclovine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Baptist Health South Florida
Breast Neoplasms
CTC Changes and Efficacy of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer
Chemotherapy before operation for malignant tumors can reduce the size of tumors to a certain extent, even eliminate micrometastases.
- Trial name
- NCT04059003
- Testing
- Taxanes or/and anthracycline-based therapy
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Shengjing Hospital
Healthy Volunteers
Phase 1 TAK-915 Single-Dose Positron Emission Tomography (PET) Occupancy Study
This phase 1 study will be conducted to examine the degree and duration of brain PDE2A enzyme occupancy /target engagement as a function of TAK-915 plasma concentration in order to guide dosing and schedule for future clinical…
- Trial name
- NCT02584569
- Testing
- TAK-915
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Takeda
Coronary Artery Disease (CAD), Ischemic Heart Disease
A Study of Flurpiridaz (18F) Injection for PET Imaging for Assessment of MPI Quality Using HPLC and SPE Manufacturing Processes
This was a Phase 2 prospective, randomized, crossover study of Flurpiridaz (18F) Injection for PET-MPI in participants referred for evaluation of known coronary artery disease (CAD) or for suspected CAD with intermediate to high…
- Trial name
- NCT04594941
- Testing
- Flurpiridaz (18F) Injection
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- GE Healthcare
Temporomandibular Joint, Conservative Treatment Therapy
The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ)
Temporomandibular joint disorders (TMD) are a common musculoskeletal problem with an estimated 40-75 percent of the population reporting at least one sign.
- Trial name
- NCT01471418
- Testing
- PET/CT with 18-FDG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Atherosclerosis
Non-Invasive Imaging of Atherosclerosis
The purpose of this study is to develop and validate novel magnetic resonance imaging (MRI), dynamic contrast enhanced (DCE)-MRI and positron emission tomography (PET)/MR techniques for the detection and risk stratification of…
- Trial name
- NCT01418313
- Where
- United States
- Volunteers
- 886 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
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