Clinical trials: Post Acute Sequelae of COVID-19
Long Covid19
Diaphragm Dysfunction After COVID-19 as Determined by Dynamic Chest Radiography
Dynamic chest radiography (DCR) is a rapid and easily performed technique that captures real-time continuous images of the moving chest.
- Trial name
- DD-COVID-19 (NCT06175455)
- Testing
- dynamic chest radiography
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Long COVID, Post COVID-19 Condition
Effect of Hi-OxSR for the Treatment of Post COVID Condition
The RECLAIM study platform will be used to explore whether the use of the Hi-OxSR device improves the symptoms of post covid cognitive dysfunction.
- Conditions
- Long COVID, Post COVID-19 Condition, Post Acute Sequelae of COVID-19
- Trial name
- RECLAIM-HiOxSR (NCT06928506)
- Testing
- Hi-OxSR device, Hi-Ox device
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
NC Testing in LC & POTS
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction.
- Trial name
- NCT05914649
- Testing
- IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Post-Acute COVID-19 Syndrome, Long COVID-19
Synbiotic Therapy for NP-PASC
Gut microbiome dysbiosis has been noted in patients with Post-acute sequelae (PASC) of Severe Acute Respiratory Syndrome-CoronaVirus -2 (SARS-CoV-2).
- Trial name
- NCT06620406
- Testing
- Synbiotic IVS-1, Maltodextrin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Columbia University
Long COVID
A Practical RCT of TCM in the Treatment of LCOVID and Analysis of Syndrome Types and Medication Characteristics.
This is a multi-center, outcome assessor-blinded, practical randomized controlled trial, aiming to compare the actual clinical effectiveness of individualized traditional Chinese medicine and conventional Western medicine in the…
- Trial name
- NCT06095258
- Testing
- Traditional Chinese medicine treatment, Western medicine treatment
- Volunteers
- 162 people
- Sponsor
- Chinese University of Hong Kong
Post-Acute COVID-19 Syndrome
Microbial and Cytokine Signatures in Long COVID Patients
We aim at identifying potential biomarkers in plasma indicative of post-acute coronavirus SARS-CoV-2 Syndrome (Long COVID). Our case-control study will compare Long COVID patients to healthy patients from Sutter Health.
- Trial name
- NCT07074158
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Palo Alto Medical Foundation
Dysexecutive Syndrome, Post-Acute Sequelae of COVID-19
Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC)
The main goal of this study is to improve dysexecutive symptoms (e.g., sustained attention, processing speed) in patients exhibiting post-acute sequelae of COVID-19 (PASC) through home-based transcranial direct current…
- Trial name
- NCT05092516
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Long COVID
Prospective, Open-label Study of Seraph 100 in Patients With Prolonged COVID (PC)
This study will use a prospective, open, single-arm design, in which a group of 100 patients with a diagnosis of prolonged COVID, previously selected according to inclusion and exclusion criteria, and who have undergone informed…
- Trial name
- NCT06637800
- Testing
- Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100)
- Where
- Mexico
- Sponsor
- ExThera Medical Corporation
Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
This study investigates a non-pharmacological treatment approach for Postural Orthostatic Tachycardia Syndrome (POTS), a disorder of the autonomic nervous system characterized by an excessive increase in heart rate upon standing.
- Trial name
- NCT06996314
- Testing
- TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB)
- Volunteers
- 100 people
- Sponsor
- Ali Kapan
Long COVID, Long COVID-19
AT1001 for the Treatment of Long COVID
The primary objective of this study is to evaluate the safety and efficacy of Larazotide (AT1001) versus placebo in children and adults 7 to ≤50 years of age who present with symptoms of Long COVID in the presence of SARS-CoV-2…
- Conditions
- Long COVID, Long COVID-19, Post Acute COVID-19 Syndrome, Post Acute Sequelae of COVID-19
- Trial name
- NCT05747534
- Testing
- Larazotide Acetate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Massachusetts General Hospital
Long COVID
Clinical and Biological Characterization of Post COVID-19 Syndrome
The goal of this observational study is to describe the symptoms that persist for more than 12 weeks after the acute episode in participants who had COVID-19, and compare the functional, socioeconomic and occupational effects…
- Trial name
- NCT05735782
- Testing
- Clinical, mental health and psychosocial profile of Post-COVID-19 syndrome, Diagnostic performance of echocardiographic and biological markers in Post-COVID-19 syndrome
- Where
- Argentina
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Arturo Jauretche National University
Post COVID-19 Condition, Long COVID
Pycnogenol® in Post-COVID-19 Condition
To determine the effect of Pycnogenol® versus placebo on patient-reported health status in people with post COVID-19 condition.
- Trial name
- PYCNOVID (NCT05890534)
- Testing
- Pycnogenol®
- Where
- Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Post COVID-19 Condition, Post-COVID-19 Syndrome
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of…
- Conditions
- Post COVID-19 Condition, Post-COVID-19 Syndrome, Post-COVID Syndrome, COVID-19
- Trial name
- PCS-HBOT (NCT06082518)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device).
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Long COVID
Characterization of the Immunometabolic Signature in Long COVID-19.
The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC).
- Trial name
- LoCo-ImMet (NCT05758480)
- Testing
- Blood sample (at inclusion and 6 months later), Patient questionnaires (at inclusion and 6 months later)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Post COVID-19 Condition
Bright Light Therapy for Post-COVID-19 Fatigue
This is a randomized placebo-controlled trial to examine the efficacy of two-week bright light therapy for patients with post-COVID-19 fatigue.
- Trial name
- NCT05677932
- Testing
- Bright light therapy, Dim red light therapy
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Chinese University of Hong Kong
Persistent COVID-19, B Cell Malignancies
Evaluation of Prevalence and Risk Factors of Persistent COVID-19 in Immunocompromised Patients
Spontaneous international multicenter retrospective and prospective observational study which objective is to evaluate the prevalence and risk factors of persistent SARS-CoV-2 infection within a population of hematology patients…
- Trial name
- PERsiCO (NCT06576102)
- Testing
- Persisting SARS-CoV-2 infection
- Where
- 5 sites in Italy, Spain
- Volunteers
- 204 people
- Sponsor
- Maddalena Giannella
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Long COVID
Tele-exercise Training Program for Long COVID
Patients with long coronavirus disease (COVID-19) experience multisystem symptoms and reduced quality of life (QOL). Proactive interventions are needed to enhance health outcomes.To investigate the effects of a 12-week…
- Trial name
- NCT07553897
- Testing
- Telehealth exercise training program, Education and self-exercise
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Long COVID-19, Post-COVID-19 Syndrome
Long Term Impact of COVID-19
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has a devastating effect on human lives, including over 6.6 million death as of November 2022.
- Conditions
- Long COVID-19, Post-COVID-19 Syndrome, COVID-19
- Trial name
- NCT05813574
- Testing
- Observational patient reported outcomes
- Where
- Netherlands
- Volunteers
- 835 people
- Sponsor
- Medisch Spectrum Twente
Long COVID
A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID.
This decentralized trial is a Phase 2, 1:1 randomized, double-blind, superiority, placebo-controlled study in an anticipated 100 non-hospitalized highly symptomatic adult participants with long COVID.
- Trial name
- NCT05668091
- Testing
- Nirmatrelvir, Ritonavir
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Harlan M Krumholz