Clinical trials: Post Cerebral Hemorrhage
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
Intracerebral Hemorrhage
Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage
To evaluate the efficacy of using IPC during the acute phase of ICH in the prevention of VTE. To assess the safety and efficacy of additional therapy with enoxaparin.
- Trial name
- NCT00699465
- Testing
- enoxaparin
- Where
- Finland
- Volunteers
- 320 people
- Sponsor
- University of Oulu
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache Disorders
Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial
Subarachnoid hemorrhage (SAH) is a devastating neurological disorder associated with significant mortality and morbidity rates, arising not just from the hemorrhage itself but also because of the catastrophic multisystem sequelae…
- Trial name
- SAH-BLOCK (NCT07307508)
- Testing
- Levobupivacaine Scalp block, Conventional analgesic therapy
- Where
- Qatar
- Volunteers
- 22 people
- Sponsor
- Hamad Medical Corporation
Hepatic Encephalopathy
Lactulose, L-ornithine L-aspartate, or Rifaximin Versus Placebo for Preventing Hepatic Encephalopathy in Variceal Bleeding
The aim of this study is to determine whether lactulose, L-ornithine L-aspartate, and rifaximin are effective in the prevention of the development of hepatic encephalopathy in cirrhotic patients with acute variceal bleeding
- Trial name
- NCT02158182
- Testing
- Lactulose, L-ornithine L-aspartate, Rifaximin
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Hospital General de Mexico
Craniocerebral Trauma, Stroke
Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes
This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC).
- Conditions
- Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
- Trial name
- TIMELY (NCT06632587)
- Testing
- Early cranioplasty, Standard-of-care cranioplasty
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cerebral Hemorrhage, Head Injury
Biomarkers Correlation With Volemia
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7…
- Conditions
- Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure
- Trial name
- ENVOL (NCT01858675)
- Testing
- Biomarkers, red blood cells and plasma assessment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France
Aneurysmal Subarachnoid Hemorrhage
The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage
The purpose of this phase II study is to further assess the safety of tiopronin in aneurysmal subarachnoid hemorrhage(aSAH) patients in order to obtain preliminary data on the efficacy of tiopronin versus placebo in reducing…
- Trial name
- NCT01095731
- Testing
- Tiopronin
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- E. Sander Connolly
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Prognosis of Neurological Function After Subarachnoid Hemorrhage
The incidence of cerebral vasospasm after aneurysm subarachnoid hemorrhage (aSAH) is as high as 70%; cerebral vasospasm（CVS） is closely related to delayed cerebral ischemia （DCI）, which is one of the important reasons for poor…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Neurological Prognosis
- Trial name
- NCT07652749
- Testing
- Intervention group
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Sleep Apnea
Effect of Sleep Apnea on Blood Pressure Control and Outcome Early After Subarachnoid Hemorrhage
In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.
- Trial name
- NCT02724215
- Testing
- Sleep Apnea Screening (Out of Center Polysomnography Device)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Subarachnoid Hemorrhage, Spontaneous
SFX-01 After Subarachnoid Haemorrhage
This is a Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of SFX-01 in Subarachnoid Haemorrhage, with exploratory evaluations of efficacy.
- Trial name
- SAS (NCT02614742)
- Testing
- SFX-01
- Where
- 3 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Evgen Pharma
Intracerebral Hemorrhage
Efficacy and Safety of Factor VIIa on Rebleeding After Surgery for Spontaneous Intracerebral Hemorrhage (ICH)
Although the role of surgical treatment is still controversial, surgical evacuation of intracerebral hematoma is a frequent practice. Rebleeding is a frequent complication in patients submitted to hematoma evacuation.
- Trial name
- PRE-SICH (NCT00128050)
- Testing
- rFactor VIIa (Eptacog alfa, NovoNordisk), rFVIIa, Sodiun chloride 0.9%
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Post Cerebral Hemorrhage
Seizures Post Intracerebral Hemorrhage
This study examines early antiepileptic treatment with valproic acid for acute cerebral hemorrhage against a placebo group immediately post event to evaluate the outcome of these patients regarding seizures and neurological…
- Trial name
- NCT01115959
- Testing
- valproic acid
- Volunteers
- 72 people
- Sponsor
- Wolfson Medical Center
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage:
Subarachnoid hemorrhage (SAH) occurs after rupture of cerebral aneurysms. Treatment of SAH focuses on avoiding medical complications including cerebral vasospasm, which may result in limited circulation to the brain.
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hyponatremia
- Trial name
- HS3 (NCT02432157)
- Testing
- HTS 3%, Standard fluid management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Chronic Subdural Hematoma, cSDH
Prospective Multi-center Single Arm Study for Subjects With Chronic Subdural Hematoma Treated With i-ED COILs, Either Alone or in Combination With Burr-holes or Mini-craniotomy
All participants will be asked to have a minimally invasive procedure for the treatment of chronic subdural hematoma, a blood clot on the brain.
- Conditions
- Chronic Subdural Hematoma, cSDH, Chronic Subdural Hematomas
- Trial name
- iCURE cSDH (NCT07214623)
- Testing
- Neuro endovascular embolic coil
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kaneka Medical America LLC
Aneurysmal Subarachnoid Hemorrhage
Delayed Cerebral Ischaemia and Coagulation Alterations After Aneurysmal Subarachnoid Haemorrhage
Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years.
- Trial name
- NCT03985176
- Testing
- ROTEM, EEG, bilateral compression ultrasound of the lower extremity veins
- Where
- Finland
- Volunteers
- 62 people
- Sponsor
- Tampere University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm After Subarachnoid Hemorrhage
Endovascular Therapy for Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Cerebral vasospasm is a common and serious complication after aneurysmal subarachnoid hemorrhage and is an important cause of delayed cerebral ischemia and poor neurological outcomes.
- Trial name
- RESCUE-CV (NCT07643922)
- Testing
- Intra-arterial and Intravenous Milrinone Therapy, Standardized Medical Management
- Where
- 2 sites in China
- Volunteers
- 306 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Observational Study of Safety and Outcomes After Minimally Invasive Surgery for Intracerebral Hemorrhage
This pilot study will examine the safety and the clinical outcomes after minimally invasive surgery (using a parafascicular technique guided by diffusion-tensor imaging) for intracerebral hemorrhage in patients selected according…
- Trial name
- MiSPACE (NCT01920763)
- Testing
- Clinical Measurement
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Subarachnoid Hemorrhage, Pneumonia, Bacterial
Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)
Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI).
- Trial name
- SAH-CIP (NCT05094349)
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Brest
Subarachnoid Hemorrhage, Aneurysmal, Mental Fatigue
Understanding Mental Fatigue After Subarachnoid Hemorrhage
Fatigue is among the most frequently reported sequelae in stroke survivors. For a specific stroke diagnosis, aneurysmal subarachnoid hemorrhage (aSAH), fatigue, in general, is reported to be present in 30 to 90% of the patients.
- Trial name
- NCT06239142
- Volunteers
- 64 people
- Sponsor
- Sahlgrenska University Hospital