Clinical trials: Post Cerebral Hemorrhage
Intracerebral Hemorrhage
Glibenclamide Advantage in Treating Edema After Intracerebral Hemorrhage
The purpose of the present study is to explore the efficacy of small doses of oral glibenclamide on brain edema after acute primary intracerebral hemorrhage (ICH), and improving the prognosis of patients.
- Trial name
- GATE-ICH (NCT03741530)
- Testing
- Glibenclamide Tablets, Standard management for ICH
- Where
- 5 sites in China
- Volunteers
- 220 people
- Sponsor
- Xijing Hospital
Traumatic Brain Injury, Subarachnoid Hemorrhage
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic…
- Trial name
- NCT06103201
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Safety and Efficacy of Nicardipine for the Control of Blood Pressure After SAH
The purpose of this research is to explore ways to improve and simplify control of blood pressure in patients with SAH or ICH. This research will be done by comparing tow different medications that are routinely used to help…
- Trial name
- NCT00490464
- Testing
- Nicardipine and Nipride
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Illinois Chicago
Aneurysmal Subarachnoid Hemorrhage
EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH
The intention of the study is to investigate whether drainage of cerebral spinal fluid via a lumbar route ("Tuohy-drain") will improve outcome after intracranial aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- EARLYDRAIN (NCT01258257)
- Testing
- Insertion of a lumbar drain
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Primary Intracerebral Hemorrhage, Early Mobilization
Quality Improvement Initiative for Enhancing Early Mobilization in Intracerebral Hemorrhage Patients
Primary intracerebral hemorrhage (ICH) is a severe and life-threatening condition with a high mortality rate, reaching up to 50% within the first month.
- Trial name
- NCT06811350
- Testing
- post-implementation cohort
- Where
- Taiwan
- Volunteers
- 198 people
- Sponsor
- National Taiwan University Hospital
Traumatic Brain Injury, Middle Cerebral Artery Stroke
Intracranial Pressure After Decompressive Craniectomy
Observational study to investigate the natural course of intracranial pressure (ICP) after decompressive craniectomy (DC) using long-term telemetric ICP monitoring.
- Conditions
- Traumatic Brain Injury, Middle Cerebral Artery Stroke, Intracranial Hemorrhages, Intracranial Hypertension
- Trial name
- NCT03364634
- Testing
- Intracranial pressure monitoring
- Volunteers
- 17 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Intracerebral Hemorrhage, Hemorrhagic Stroke
Haptic-Assisted Virtual Reality Upper-Limb Rehabilitation After Intracerebral Haemorrhage
After spontaneous intracerebral haemorrhage (ICH), many survivors have persistent weakness of the arm and hand. Virtual reality (VR) training with haptic (force-feedback) devices may support upper-limb recovery, but evidence…
- Conditions
- Intracerebral Hemorrhage, Hemorrhagic Stroke, Paresis
- Trial name
- CR-4-Health-VR (NCT07882810)
- Testing
- Haptic-assisted virtual reality training (Bimeo PRO), Conventional rehabilitation
- Where
- 3 sites in Austria, Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury
Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage
An investigator-initiated clinical drug study Main Objective: To explore neuroprotective properties of xenon in patients after aneurysmal subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury, Cerebral Ischemia, Cerebral Infarction
- Trial name
- Xe-SAH (NCT04696523)
- Testing
- Xenon, air/oxygen
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Hematoma, Subdural, Chronic
Exhaustive Drainage Versus Fixed-time Drainage for Chronic Subdural Hematoma After One-burr Hole Craniostomy
A prospective, multicenter, randomized controlled trial is designed to compare the recurrence rates and clinical outcomes in patients with chronic subdural hematoma using exhaustive drainage or fixed-time drainage after one-burr…
- Trial name
- ECHO (NCT04573387)
- Testing
- Operation, Fixed-time drainage, Exhaustive drainage
- Where
- 17 sites in China
- Volunteers
- 309 people
- Sponsor
- Beijing Tiantan Hospital
Partial Corticotrope Insufficiency
Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency
The purpose of this study is to evaluate the efficacy of hydrocortisone replacement therapy in patients with partial cortisol deficiency after traumatic brain injury or subarachnoid hemorrhage on cognitive function.
- Trial name
- CSMünchen01 (NCT01089075)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Intracerebral Hemorrhage
Prevention of Hypertensive Injury to the Brain by Intensive Treatment of Blood Pressure After Intracerebral Haemorrhage (PROHIBIT-ICH)
PROHIBIT-ICH will randomise participants (target=112) to compare a strategy of intensive blood pressure (BP) treatment (target <120/80 mm Hg) guided by remote telemetric home BP monitoring, versus standard primary care, in adult…
- Trial name
- PROHIBIT-ICH (NCT03863665)
- Testing
- A&D BP Digital Blood Pressure Monitor (UA-767PBT-Ci) CE Declaration UA-767PBT-Ci
- Where
- 16 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- University College, London
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage
Brain Imaging After Non-traumatic Intracranial Hemorrhage (SAVEBRAINPWI)
The study is an observational prospective evaluation of an approved and unchanged clinical management, evaluating different diagnosis methods to assess brain perfusion in patients with an aneurysmal or AVM-related intracranial…
- Conditions
- Aneurysm, Ruptured, Aneurysmal Subarachnoid Hemorrhage, Arteriovenous Malformations, Intracranial Aneurysm
- Trial name
- SAVEBRAINPWI (NCT05276934)
- Testing
- Brain computed tomography
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Subarachnoid Hemorrhage
Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; to explore the…
- Trial name
- ABASH (NCT01232400)
- Testing
- Esmolol
- Where
- United States
- Sponsor
- University of Michigan
Stroke, Chronic Stroke
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH)
- Trial name
- PHATHOM (NCT07053917)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Delayed Cerebral Ischemia After Subarachnoid Hemorrhage, Ischemic Stroke of Large or Medium Vessels
Thrombo-inflammation in Acute Neurovascular Diseases: Definition of New Therapeutic Targets (TARGETS)
The objective of this observational study is to compare the relative concentrations of various thrombo-inflammatory markers at different follow-up time points in: patients with or without delayed cerebral ischemia after…
- Trial name
- NCT07354321
- Volunteers
- 499 people, healthy volunteers welcome
- Sponsor
- François Delvoye
Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial
Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma
The clinical-functional result after frontal and parietal burr-hole trepanation for the treatment of chronic subdural hematoma (cSDH) is effective with regards to control of the hematoma and regression of symptoms (headache…
- Conditions
- Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial, Haematoma;Subdural;Traumatic
- Trial name
- CORRECT-SCAR (NCT03755349)
- Testing
- Placement of burr-hole covers, No placement of burr-hole covers
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- University of Zurich