Clinical trials: Post Cerebral Hemorrhage
Chronic Subdural Hematoma
Endovascular Embolization of Chronic Subdural Hematomas After Surgery
Chronic subdural hematomas (CSH) are one of the most frequent pathologies in emergency neurosurgical practice. Standard therapy for symptomatic CSH is surgical drainage.
- Trial name
- ENCLOSURE (NCT05220826)
- Testing
- Post surgical embolization of middle meningeal artery with liquid embolic agents (ethylene vinyl alcohol copolymers as Onix, Squid, Phil or Libro)
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Intracerebral Hemorrhage, Cerebral Edema
Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage
The purpose of this study is to test the safety and effectiveness of a single dose of fingolimod in patients with primary spontaneous intracerebral hemorrhage (ICH).
- Conditions
- Intracerebral Hemorrhage, Cerebral Edema, Stroke Hemorrhagic, Intracerebral Hemorrhage, Hypertensive
- Trial name
- FITCH (NCT04088630)
- Testing
- Fingolimod, Open-label Fingolimod
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Acute Ischemic Stroke, Intracranial Hemorrhage
Hemodynamic in Postreperfusion Period and Functional Recovery in Acute Ischemic Stroke Patients
The investigators are suggtesting that lower goals of systolic blood pressure after intravenous thrombolysis may reduce the risk of hemorrhagic complications and improve functional outcomes after acute ischemic stroke.
- Trial name
- NCT05517109
- Testing
- Hemodynamic goal including lower goal of systolic blood pressure
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Northern State Medical University
Chronic Subdural Hematoma
The Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Hematoma (FINISH)
FINISH-trial is a prospective, randomized, controlled, parallel group non-inferiority trial comparing single burr-hole evacuation of chronic subdural hematoma (CSDH) with intraoperative irrigation (IR) and evacuation of CSDH…
- Trial name
- FINISH (NCT04203550)
- Testing
- Intraoperative irrigation, No irrigation
- Where
- Finland
- Volunteers
- 587 people
- Sponsor
- Helsinki University Central Hospital
Intracerebral Hemorrhage
Association Between Haptoglobin Genotype and Brain Swelling
Intracerebral hemorrhage is bleeding into the brain and is a major cause of stroke and other complications. Brain injury from intracerebral hemorrhage occurs in two phases.
- Trial name
- NCT02054117
- Testing
- Intracerebral Hemorrhage
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Trephined Syndrome, Sinking Skin Flap Syndrome
Prevalence of Trephined Syndrome After Decompressive Craniectomy
Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy.
- Conditions
- Trephined Syndrome, Sinking Skin Flap Syndrome, Traumatic Brain Injury, Stroke
- Trial name
- TS (NCT03186157)
- Testing
- Decompressive craniectomy, Cranioplasty
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- University Hospital, Geneva
Subarachnoid Hemorrhage, Aneurysmal, Headache
BLOCK-SAH - PPF-Block for Post-SAH Headache
BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injections with 20mg ropivacaine +…
- Trial name
- BLOCK-SAH (NCT06008795)
- Testing
- Pterygopalatine Fossa Nerve Block with Ropivacaine and Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 195 people
- Sponsor
- University of Florida
Disorders of Consciousness, Spontaneous Intracerebral Hemorrhage
Transcutaneous Auricular Vagus Nerve Stimulation for Recovery of Consciousness After Surgery for Spontaneous Intracerebral Hemorrhage
Disorders of consciousness are common after surgery for severe spontaneous intracerebral hemorrhage and are associated with high mortality, disability, and long-term dependence.
- Trial name
- TAVNS-SICH (NCT07761507)
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Hemorrhage, Atrial Fibrillation
Apixaban After Anticoagulation-associated Intracerebral Haemorrhage in Patients With Atrial Fibrillation
There is a marked lack of evidence on the optimal prevention of ischaemic stroke in patients with atrial fibrillation and a recent intracerebral haemorrhage (ICH) during treatment with oral anticoagulation.
- Trial name
- APACHE-AF (NCT02565693)
- Testing
- Apixaban, Aspirin, Carbasalate calcium
- Where
- 16 sites in Netherlands
- Volunteers
- 101 people
- Sponsor
- UMC Utrecht
Subarachnoid Hemorrhage, Aneurysmal, Headache
Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage
The purpose of this study is to determine the relationship between the Neuroinflammatory response and headache pain after subarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Headache, Subarachnoid Hemorrhage
- Trial name
- HASH4-CSF (NCT03604276)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- MaineHealth
Cognitive Impairment, Intracerebral Hemorrhage
Fufang Congrong Yizhi Capsules (FCYC) of Cognitive Impairment After Intracerebral Hemorrhage
This is a randomized, controlled clinical study conducted across multiple centers. The neurosurgical robot can be used to treat patients with acute intracerebral hemorrhage (ICH).
- Trial name
- NCT06673602
- Testing
- FCYC+Conventional treatment, conventional treatment
- Where
- 6 sites in China
- Volunteers
- 200 people
- Sponsor
- Qinhuangdao Hospital of Traditional Chinese Medicine
Subarachnoid Hemorrhage
Impact of Ultra-Early Intracranial Aneurysm Treatment in SAH
This is the first prospective study in Hong Kong that recruit patients with poor neurological status after intracranial aneurysm rupture in all seven public neurosurgical services in Hong Kong.
- Trial name
- UEAT (NCT03894202)
- Where
- China
- Volunteers
- 293 people
- Sponsor
- Chinese University of Hong Kong
Subarachnoid Hemorrhage
Neuroinflammation and Bispectral Index After Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is associated with a high mortality and frequently leads to severe disability in survivors caused by cerebral vasospasm and infarction.
- Trial name
- NCT01516671
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Subdural Hematoma, Atrial Fibrillation
Anticoagulation Therapy Timing in Atrial Fibrillation After Acute and Chronic Subdural Hematoma
Subdural hematoma (SDH) is a common disorder that typically results from head trauma and has increased in prevalence in recent decades.
- Trial name
- ATTAACH (NCT05472766)
- Testing
- Direct Acting Oral Anticoagulant starting at Day 30, Direct Acting Oral Anticoagulant starting at Day 90
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Brain Injuries, TBI (Traumatic Brain Injury)
Dynamic and Static Autoregulation After Brain Injury
The aim of the study assesses static and dynamic cerebrovascular autoregulation daily over one week in patients with traumatic brain injury or intracranial hemorrhage to quantify the temporal profile of the autoregulatory status.
- Conditions
- Acute Brain Injuries, TBI (Traumatic Brain Injury), Intracranial Hemorrhages
- Trial name
- NCT01069250
- Testing
- There are no interventions in this study
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Johannes Gutenberg University Mainz
Ischemic Stroke, Intracranial Hemorrhage
Stroke Education Intervention Trial - Pilot
The objectives of the trial of a medication-coach program for patients with stroke or transient ischemic attack are to pilot test the study design, the intervention components and the data collection forms and refine them for a…
- Conditions
- Ischemic Stroke, Intracranial Hemorrhage, Transient Ischemic Attack
- Trial name
- AVAIL II (NCT01115660)
- Testing
- stroke education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Severe Trauma (With or Without Traumatic Brain Injury)
Post Traumatic Critical Complications: a Prospective Cohort Study (ATLANREA)
The purpose of this observational epidemiological study is to investigate the management and the complications associated with severe trauma.
- Trial name
- NCT02426255
- Testing
- Collection of medical data from ICU patients
- Where
- 5 sites in France
- Volunteers
- 5,000 people
- Sponsor
- Nantes University Hospital
Carotid Artery Diseases
Highest Efficacy of Dual Antiplatelet Therapy After Carotid Artery Stenting in High Bleeding Risk Patients
The optimal duration of dual antiplatelet therapy (DAPT) after carotid artery stenting (CAS) in patients at high bleeding risk (HBR) has not been established in randomized controlled trials.
- Trial name
- NCT06276374
- Testing
- Intervention 1(DAPT): Drug: Aspirin 100mg + Clopidogrel 75mg. Intervention 2(SAPT): Drug: Asprin 100mg or Clopidogrel 75mg
- Where
- South Korea
- Volunteers
- 1,556 people
- Sponsor
- Woo-Keun Seo
Subarachnoid Hemorrhage, Aneurysmal, Cognitive Dysfunction
Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH
The goal of this clinical trial is to Explore and verify whether 40Hz audio and binaural beat 40Hz audio can improve the postoperative cognitive dysfunction seen in patients with aneurysmal subarachnoid hemorrhage.
- Trial name
- GES-aSAH (NCT06346015)
- Testing
- Gamma Entrainment Stimulation
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Vasospasm, Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation in Patients With Cerebral Vasospasm After Subarachnoid Haemorrhage: VasoStim Study
Cerebral vasospasm is characterized by a vasoconstriction of cerebral arteries causing a reduction of cerebral blood flow (CBF) and leading to ischemia and infarction of the brain parenchyma.
- Trial name
- NCT05150002
- Testing
- Spinal cord stimulation
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern