Clinical trials: Post Operative Delirium
Valvular Surgery
Relationship Between Postoperative Delirium and Heart Function in Valvular Surgery
Delirium is an acute brain lesion characterized by abnormalities of consciousness, attention, cognition and sensation. Many brain diseases such as stroke, traumatic brain injury and intracranial hypertension can lead to cardiac…
- Trial name
- NCT05211934
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Anzhen Hospital
Emergence Agitation
Effect of Extubation Under Deep Anesthesia on Emergence Agitation of Nasal Surgery
This study analyzed the relationship between extubation timing and Emergence agitation in 18-60 years old adults undergoing nasal surgery, such as nasal septum correction, endoscopic sinus surgery, and nasal bone fracture…
- Trial name
- NCT04844333
- Testing
- Extubation under deep anesthesia
- Where
- 3 sites in China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Agitation, Emergence
Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression…
- Trial name
- NCT05264077
- Testing
- Dexmedetomidine Hydrochloride
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Open-Heart Surgery
Development of Delirium in Patients Undergoing Open-Heart Surgery
Malnutrition is a prevalent issue among patients undergoing cardiac surgery. This can lead to delirium risk factors, including postoperative functional and cognitive impairment.
- Trial name
- NCT06195592
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kubra Gunes
Adult Patients Undergoing Open Heart Surgery
Prospective Validation of the Model Predicting Postoperative Delirium Occurrence With Machine Learning-based Analysis of Intraoperative Biological Signals During Anesthesia in Cardiac Surgery
Postoperative delirium (POD) not only increases the length of hospitalization and intensive care unit stay and medical costs, but is also closely associated with negative prognosis, including postoperative mortality, increased…
- Trial name
- NCT05320965
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Postoperative Delirium (POD), Prostate Cancer
A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery
Cases were included based on the inclusion and exclusion criteria, and induction, maintenance, and recovery were conducted in accordance with the standard protocol for general anesthesia.
- Conditions
- Postoperative Delirium (POD), Prostate Cancer, Kidney Tumor
- Trial name
- NCT07480044
- Testing
- Transcranial Magnetic Stimulation Device
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Zhejiang University
Postoperative Delirium, Postoperative Pain, Acute
Postoperative Delirium and Analgesia in Elderly Patients
This study aims to evaluate the effects of different postoperative analgesic approaches on postoperative delirium in elderly patients undergoing total knee arthroplasty.
- Trial name
- NCT07849517
- Testing
- adductor canal block and biFes block including bupivacain, Periarticular infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
INVESTIGATE THE ASSOCIATION BETWEEN VIRAL NEUROTOXIC INFECTION AND POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
In the last two decades, viral infections have increased dramatically : the 2003 severe acute respiratory syndrome coronavirus outbreak, the 2009 swine flu pandemic, the 2012 Middle East respiratory syndrome coronavirus outbreak…
- Trial name
- CONNECTED (NCT05806827)
- Testing
- Virological screening
- Volunteers
- 1,685 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Emergence Delirium, Hypoactive Delirium
An Observational Study of Emergence and Hypoactive Delirium After Anesthesia
Early postoperative negative behaviour (ePONB), such as pain, emergence delirium (ED) and hypoactive delirium, is a relevant clinical problem during recovery from anesthesia.
- Conditions
- Emergence Delirium, Hypoactive Delirium, Pain
- Trial name
- NCT05582005
- Testing
- noninvasive blood pressure, 3 lead ECG, peripheral oxygen saturation
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Preoperative Gabapentin for Post-tonsillectomy Pain in Children
The typical post-operative course for children following surgical removal of their tonsils and adenoids can be challenging, especially for pain control.
- Trial name
- NCT01707420
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Postoperative Delirium
Survey Assessing the Level of Knowledge of Postoperative Delirium in Poland.
Postoperative Delirium (POD) is one of the most common complications occurring after surgery with an incidence ranging from 4 to 53%.
- Trial name
- PODinPOL (NCT04250610)
- Testing
- Survey
- Where
- 2 sites in Poland
- Volunteers
- 460 people
- Sponsor
- Pomeranian Medical University Szczecin
Femur Head Necrosis
Anesthesia Depth's Influence on Postoperative Delirium
The investigators,according to the eligibility criteria,plane to choose 80 elderly anticipates who will undergo selective hip replacement surgery.This participants will be randomly divided into 2 groups:light anesthesia depth…
- Trial name
- NCT02972762
- Testing
- Diprivan
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiangya Hospital of Central South University
Cognitive Dysfunction, Postoperative Delirium
Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction
Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients after surgery. Two acute cognitive dysfunctions have been described: postoperative delirium (PD) and postoperative…
- Trial name
- NCT04214496
- Testing
- Sedline
- Where
- 2 sites in Chile
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Chile
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy
Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients
Background: Adenotonsillectomy is one of the most common pediatric surgeries and is often complicated by postoperative emergence agitation (POEA), a short-lived but distressing state of confusion and restlessness after…
- Trial name
- POEA (NCT07433231)
- Testing
- Magnesium sulfate (MgSO4) infusion, Propofol bolus, Ketamine bolus
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ayfer Kaya Gök
Delirium, Thoracic Surgery
Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
This study will assess the incidence and risk factors for post-operative delirium in patients undergoing thoracotomy. Specifically, the study will assess if there is any relationship between an intra-operative decrease in brain…
- Trial name
- NCT03165539
- Testing
- Cerebral oxygen saturation monitoring
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Adults Undergoing Otorhinolaryngology Surgery
Intravenous Magnesium Sulphate Versus Dexmedetomidine for Prevention of Emergence Agitation in Adult Otorhinolaryngologic Surgery
The goal of this clinical trial is to learn whether intravenous magnesium sulphate can reduce emergence agitation as effectively as intravenous dexmedetomidine in adult patients undergoing otorhinolaryngology surgery under…
- Trial name
- NCT07544173
- Testing
- Magnesium sulphate, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Universitas Indonesia
Delirium - Postoperative, Neuronal Damage
The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium
Postoperative delirium is a frequent and serious complication in older surgical patients, linked to prolonged hospitalization and long-term cognitive decline.
- Conditions
- Delirium - Postoperative, Neuronal Damage, Blood Brain Barrier Defect, Postoperative Complications
- Trial name
- SPOT_ON_BRAIN (NCT07411612)
- Testing
- laboratory biomarker analysis, 3D-CAM/CAM-ICU
- Where
- Austria
- Volunteers
- 1,170 people
- Sponsor
- Medical University of Vienna
Delirium in Old Age
Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery
Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.
- Trial name
- NCT06653465
- Testing
- Acetaminophen, Saline
- Volunteers
- 1,930 people
- Sponsor
- RenJi Hospital
Delirium
Rivastigmine Patch Effect on the Post-operative Delirium in Patients at Risk of Dementia.
Delirium is a common and serious condition and is associated with adverse outcome. The elderly who have cognitive dysfunction are expected to show delirium more frequently.
- Trial name
- NCT02413554
- Testing
- Rivastigmine patch
- Volunteers
- 62 people
- Sponsor
- Chung-Ang University Hospital