Clinical trials: Post Operative Pain Control, open to volunteers
Post-operative Pain
Presacral Nerve Block Versus Sham Block on Post-operative Pain for Total Laparoscopic Hysterectomy
The study is a single-center parallel group randomized controlled trial comparing the administration of a presacral nerve block using 20mL of local ropivacaine 5.0mg/ml versus 20mL of normal saline (sham block) on post-operative…
- Trial name
- NCT05953766
- Testing
- Ropivacaine injection, Normal saline injection
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Wound Healing and Prevention, Oral Inflammation
Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva
The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation.
- Conditions
- Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management
- Trial name
- NCT07095556
- Testing
- Low-level laser therapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post-operative Pain
Dextromethorphan for Treatment of Postoperative Pain
A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain
- Trial name
- NCT05278494
- Testing
- Dextromethorphan Hydrobromide
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Nathanael Heckmann
Laparotomy
IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia
The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through…
- Trial name
- NCT06559969
- Testing
- Intravenous administered opioid, Epidural administered opioid
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Iowa
Postoperative Pain Following Knee Arthroplasty
Evaluating Suzetrigine for Pain Control Following TKA
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine works to treat pain after total knee replacement surgery in adults. It will also learn about the safety of suzetrigine.
- Trial name
- NCT07357376
- Testing
- Suzetrigine
- Volunteers
- 210 people
- Sponsor
- AdventHealth
Pulp Necrosis
Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar
This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars.
- Trial name
- NCT07435883
- Testing
- triton irrigation protocol, conventional irrigation group
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- sara hosny mostafa
Pain, BPH With Urinary Obstruction
Optimizing Pain Control in Transurethral Resection of the Prostate
The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard…
- Conditions
- Pain, BPH With Urinary Obstruction, BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
- Trial name
- NCT04102566
- Testing
- Ibuprofen 600 mg, Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
To Clinically Compare Post-operative Pain Between Free Gingival Grafts Stabilization Around Natural Teeth Using Titanium Tacks vs Suturing Technique
Evaluation of Post-operative Pain After Stabilization of Free Gingival Graft for Keratinized Tissue Augmentation Around Natural Teeth Using Titanium Tacks Versus Standard Suturing Technique.
The goal of this clinical trial is to learn whether titanium tacks can be used as an alternative to sutures for stabilization of free gingival grafts (FGG) around natural teeth.
- Trial name
- NCT07655349
- Testing
- Free gingival grafting (FGG) using titanium tacks for stabilization, Free gingival grafting (FGG) using sutures for stabilization.
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Karim Abdelrahim Mohamed Abdelsamad
Pain Relief After Arthroscopic Anterior Cruciate Ligament Reconstruction
Oral Melatonin With Intra Articular Analgesia on Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction
Anterior Cruciate Ligament Reconstruction (ACLR) is a common orthopedic procedure that is accompanied by moderate to severe postoperative pain and is primarily performed on an outpatient basis.
- Trial name
- ACLR (NCT07096635)
- Testing
- Melatonin, Starch tablets
- Volunteers
- 50 people
- Sponsor
- Assiut University
Patella Fracture
Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation
The objective of this study is to demonstrate the safety and efficacy of an intra-articular analgesics cocktail injection for post-operative patella fracture fixation patients, by comparing post-operative pain relief and…
- Trial name
- NCT07006168
- Testing
- Ketorolac 15mg, Triamcinolone Acetonide 40mg, Ropivacaine HCL 1% 15ml
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The University of Hong Kong
Dental Pulp Necrosis, Pulpitis
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure…
- Trial name
- NCT07546773
- Testing
- Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Rhinoplasty, Pain Management
Efficacy of Liposomal Bupivacaine Post Septorhinoplasty
The objective of this study is to determine if there is a difference in post-operative pain after septorhinoplasty when long-acting liposomal bupivacaine is used for local anesthesia compared to other standard local anesthetic…
- Trial name
- NCT05964868
- Testing
- Liposomal Bupivacaine, 0.25% bupivacaine with 1:200,000 epinephrine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Jessyka Lighthall
Post Operative Pain
Post Operative Infusion Pump Pain Study
This study will be a pragmatic, prospective cluster randomized trial, where clusters will formed based on sequential 2 week time increments across the study recruitment period..
- Trial name
- NCT07349810
- Testing
- Bupivacaine 0.5% Injectable Solution, Ropivacaine 0.2% Injectable Solution, 1.3% liposomal bupivacaine (Exparel)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rutgers, The State University of New Jersey
Breast Exicision Biopsy
Study Comparing Dynastat and Parestat Pain Relief Medications for Patients After Breast Surgery
The goal of this clinical trial is to learn if generic parecoxib (Parestat) works as well as the original drug (Dynastat) for treating pain after breast surgery. It will also learn about the safety of both drugs.
- Trial name
- PANDA (NCT07154446)
- Testing
- Parestat(generic parecoxib), Dynastat (original Parecoxib)
- Volunteers
- 60 people
- Sponsor
- University of Malaya
Gastric Cancer (GC), Stomach Neoplasms
TEAS for Gastrectomy Recovery
The goal of this clinical trial is to learn if transcutaneous electrical acupoint stimulation (TEAS) works to help people recover faster after laparoscopic surgery for stomach cancer.
- Trial name
- TEAS (NCT07898293)
- Testing
- Transcutaneous Electrical Acupoint Stimulation
- Where
- 8 sites in China
- Volunteers
- 104 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Supracondylar Humerus Fracture
Supracondylar Post-Operative Pain Study
The purpose of this study to investigate post-operative pain control in pediatric patients with closed supracondylar humerus fracture who undergo closed reduction and percutaneous pinning.
- Trial name
- NCT03759028
- Testing
- Ibuprofen, Oxycodone, Acetaminophen
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Spinal Fusion, Hyperglycemia
Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery
This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes…
- Conditions
- Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care
- Trial name
- TAPIS (NCT07218133)
- Testing
- Auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alexander T. Yahanda
Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty
Perioperative Colchicine for TKA
This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty, Perioperative Pain Control
- Trial name
- NCT06936709
- Testing
- Colchicine 1.8 mg + 0.6 mg
- Volunteers
- 75 people
- Sponsor
- Geisinger Clinic
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital