Clinical trials: Post Pulmonary Resection
Postoperative Air Leak
Pleurodesis Using Hypertonic Glucose to Treat Post-operative Air Leaks
The investigators will define the most appropriate safe dose of D50 to heal air leaks in patients that have undergone lung resection surgery
- Trial name
- PLUG-I (NCT03905408)
- Testing
- 50 mL of 50% Glucose, 100 mL of 50% Glucose, 150 mL of 50% Glucose
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lung Resection
Study of Postoperative Chest Tube Management
A 2 x 2 randomized study testing active versus passive drainage and regulated versus unregulated pleural pressure in patients undergoing anatomic lung resection
- Trial name
- NCT02282462
- Testing
- Reg Pressure, Unreg Pressure, Active Suction (Dig)
- Where
- 5 sites in United States
- Volunteers
- 600 people
- Sponsor
- Yale University
Uniportal-VATS, Lung Resection Procedures
Serratus Posterior Superior Intercostal Plane (SPSIP) Block Versus Intercostal Nerve (ICN) Block in Patients Undergoing Uniportal-VATS.
This study aims to assess the effectiveness of the Serratus Posterior Superior Intercostal Plane (SPSIP) block compared to the Intercostal Nerve (ICN) block for postoperative pain control, reduction of opioid analgesic…
- Conditions
- Uniportal-VATS, Lung Resection Procedures, Locoregional Anesthesia, Post-operative Pain Management
- Trial name
- SPUV (NCT07250373)
- Testing
- SPSIP block, ICN block
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Cancer
MRD Monitoring in Lung Cancer After Resection
The conception of molecular residual disease (MRD) extending from hematologic tumor to solid tumors. Evidences supporting MRD evaluation for lung cancer by liquid biopsy has gradually accumulated, especially circulating tumor DNA…
- Trial name
- NCT04976296
- Testing
- MRD detection
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Guangdong Provincial People's Hospital
Post-operative Air Leaks
Observational Study of TissuePatch SF in Prevention of Air Leaks Following Lung Resection
Post-market, observational study to assess effectiveness of TissuePatch SF in managing/preventing air leaks after lung resection.
- Trial name
- NCT06934486
- Testing
- TissuePatch Sealant Film
- Volunteers
- 250 people
- Sponsor
- C. R. Bard
Air Leak From Lung
Pneumostasis With Use of Bio-absorbable Mesh and Fibrin Sealant in Lung Resection
Prolonged air leak, defined as air leak present 5 days after lung resection, is one of the most common complications after lung resection.
- Trial name
- NCT04317924
- Testing
- Polyglycolic acid felt, Standard of care
- Where
- United States
- Sponsor
- Boston Medical Center
Non Small Cell Lung Cancer
Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
ctDNALung-Detect is an investigator-initiated single arm, multi-institution study designed to assess the ctDNA detection rate and its association with Relapse Free Survival (RFS) in operable stage T1-T4 (T3,T4 multifocal) N0M0…
- Trial name
- NCT05254782
- Where
- 3 sites in Canada
- Volunteers
- 360 people
- Sponsor
- University Health Network, Toronto
Lung Cancer
Post-Treatment Surveillance in Lung Cancer
There are 13.7 million Americans currently living with a history of cancer. With continued improvements in cancer treatment and increasing life expectancy, this number is expected to reach nearly 18 million within the next…
- Trial name
- NCT03475420
- Volunteers
- 9,613 people
- Sponsor
- University of Virginia
Non-Small Cell Lung Cancer
Adjuvant EGFR-TKI Therapy After Surgery for EGFR-Mutant High-Risk Stage IA2-IIB NSCLC
This prospective, multicenter patient registry is designed to evaluate the effectiveness and safety of postoperative EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients with completely resected EGFR-mutant high-risk…
- Trial name
- NCT07837739
- Testing
- Adjuvant EGFR-TKI Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Postoperative Atrial Fibrillation, Lung Surgery
Perioperative Statins to Prevent AFib After Lung Surgery
The goal of this clinical trial is to learn whether short-term treatment with atorvastatin can prevent new abnormal rapid heart rhythms after lung surgery in adults aged 60 years or older who are scheduled to have a lung segment…
- Trial name
- STAT-LUNG (NCT07727681)
- Testing
- Atorvastatin
- Where
- 2 sites in China
- Volunteers
- 540 people
- Sponsor
- Peking Union Medical College Hospital
Post Operative Pulmonary Air Leak
Effectiveness of Dextrose Pleurodesis for the Management of Post-Operative Air Leak
A common complication following lung resection surgery is the presence of a post-operative air leak. This occurs when the resected lung tissue does not seal adequately, resulting in continued leakage of air from the lung.
- Trial name
- NCT07548047
- Testing
- 50% Dextrose Pleurodesis, Standard of Care Chest Drainage
- Volunteers
- 80 people
- Sponsor
- Thomas Jefferson University
Lung Tumor Resuction
Effects of Buteyko Breathing Technique Versus Incentive Spirometer on Breath Holding Time, Cardiopulmonary Endurance and Quality of Life in Patients With Post Lung Tumor Resection
The pulmonary complications are the major cause of morbidity and mortality following Lung surgeries. The Buteyko breathing technique is used for reversing the health condition such as poor breathing, mouth breathing and over…
- Trial name
- NCT05118347
- Testing
- Buteyko Breathing Technique
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Shahbaz Ahmad
Lung Cancer Stage I, Lung; Node
Intra-operative Air Leak Management After Minimally Invasive Lung Segmental Resection
In patients undergoing minimally invasive thoracoscopic surgery (video-assisted thoracoscopic surgery, or VATS), a still unsolved issue is represented by intraoperative alveolar air leaks (IOAALs), which if prolonged beyond the…
- Conditions
- Lung Cancer Stage I, Lung; Node, Air Leak From Lung
- Trial name
- NCT06544200
- Testing
- Polymeric Hydrogel Matrix
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- University Hospital Padova
Lung Diseases, Carcinoma, Non-Small-Cell Lung
Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.
Open-label, phase III, randomized, stratified (PDL1- vs PDL1+), 3 arms, multicenter clinical trial. 129 resected patients (43 per arm) with stage from IB to IIIA and IIIB (N2) non-small cell lung cancer that do not achieve…
- Conditions
- Lung Diseases, Carcinoma, Non-Small-Cell Lung, Resectable Lung Non-Small Cell Carcinoma
- Trial name
- ARIAN (NCT06431633)
- Testing
- Zimberelimab, Sacituzumab govitecan, Cisplatin
- Where
- 32 sites in Spain
- Volunteers
- 129 people
- Sponsor
- Fundación GECP
Postoperative Pain
Pain Control of Thoracoscopic Major Pulmonary Resection
The purpose of this study is to evaluate whether pre-emptive local bupivacaine injection is a better alternative pain control modality than the conventional intravenous patient controlled analgesia.
- Trial name
- NCT01758809
- Testing
- Pre-emptive bupivacaine wound infiltration, intravenous patient controlled analgesia
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Bundang Hospital
Non-small Cell Lung Cancer
Study of Pembrolizumab (MK-3475) vs Placebo for Participants With Non-small Cell Lung Cancer After Resection With or Without Standard Adjuvant Therapy (MK-3475-091/KEYNOTE-091)
In this study, participants with Stage IB/II-IIIA non-small cell lung cancer (NSCLC) who have undergone surgical resection (lobectomy or pneumonectomy) with or without adjuvant chemotherapy will be treated with pembrolizumab or…
- Trial name
- PEARLS (NCT02504372)
- Testing
- Pembrolizumab
- Volunteers
- 1,177 people
- Sponsor
- Merck Sharp & Dohme LLC
Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS)
Erector Spinae Plane Block in Uniportal VATS
The main aim of this study is to compare the effectiveness of three alternative techniques (continuous Erectus Spinae Plane Block : c-ESPB; continuous Serratus Anterior Plane Block : c-SAPB; and Intercostal Nerve Block: ICNB) in…
- Conditions
- Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS), Lung Resections, Post-Operative Pain, Chronic
- Trial name
- ESPB-UVATS (NCT04892901)
- Testing
- c-ESPB, c-SAPB, ICNB
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Thoracic, Pulmonary Restrictive Disease
Epidemiology and Prognosis of ARDS After Pulmonary Resection Surgery
The improvement in ARDS mortality over the last 20 years seems to be largely explained by the reduction of mechanical ventilation-induced injury (VILI).
- Conditions
- Thoracic, Pulmonary Restrictive Disease, ARDS
- Trial name
- ARDS_THO (NCT04818554)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Pleural Effusion, Pleural Effusion Malignant
The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection
Following a lung resection procedure, patients have their pleural space drained of fluid that accumulates due to the severing of proximal vessels like lymph nodes.
- Trial name
- NCT01612975
- Testing
- Naproxen
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McMaster University
Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer
Surgery With or Without Chemotherapy in Treating Patients With Stage I Non-small Cell Lung Cancer
Randomized phase III trial to compare the effectiveness of surgery with or without combination chemotherapy in treating patients who have stage I non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Bronchoalveolar Cell Lung Cancer, Large Cell Lung Cancer
- Trial name
- NCT00002852
- Testing
- paclitaxel, carboplatin, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)