Clinical trials: Post Pulmonary Resection
Non Small Cell Lung Cancer
Adjuvant Therapy Omission for Resected NSCLC Patients With Longitudinal Undetectable MRD
Molecular residual disease (MRD) has strong relationship with clinical outcome in multiple solid tumors. Here, the investigators try to verify the negative predictive value of undetectable MRD, which is considered as a superior…
- Trial name
- NCT05457049
- Testing
- Molecular residual disease test
- Where
- 5 sites in China
- Volunteers
- 180 people
- Sponsor
- Guangdong Association of Clinical Trials
Lung Neoplasms
Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.
- Trial name
- NCT01307085
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Cai Li
Surgical Resection, Stereotactic Body Radiotherapy
Post SBRT Pulmonary Metastasectomy (PSPM) Trial
The goal of this study is to determine the effectiveness of SBRT on reducing tumor viability at a pathologic level and also to evaluate the effects of combined modality treatment on low volume pulmonary metastases, in hopes of…
- Conditions
- Surgical Resection, Stereotactic Body Radiotherapy, Lung Cancer, Pulmonary Metastasectomy
- Trial name
- PSPM (NCT04160143)
- Testing
- Surgical resection and stereotactic body radiation therapy (SBRT)
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Thoracic Surgery Lung, Post-operative Thoracic Air Leak
A Phase II Prospective, Single Blinded, Randomized Trial of Hemopatch Compared to Standard Techniques to Achieve Air Leak Control After Complex Thoracic Surgical Procedures
The purpose of this study is to explore whether the addition of Hemopatch to standard care can reduce prolonged air leaks and shorten the use of air drainage tube after surgery in thoracic lung surgery patients at high risk for…
- Trial name
- Hemopatch (NCT02364791)
- Testing
- standard techniques used to achieve air leak control, Hemopatch
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute, Naples
Ventilator-Induced Lung Injury, Inflammatory Response
Inflammatory Local Response During OLV: Protective vs Conventional Ventilation Strategy
This study evaluates the local cytokine inflammatory response during one lung ventilation in patients undergoing pulmonary lobectomy or wedge resection.
- Conditions
- Ventilator-Induced Lung Injury, Inflammatory Response, Respiratory Complication
- Trial name
- NCT03056885
- Testing
- Conventional One-Lung Ventilation, Protective One-lung ventilation
- Volunteers
- 28 people
- Sponsor
- University of Roma La Sapienza
Postoperative Analgesia
Study of Postoperative ICC Analgesia
This study is to examine the analgesic effectiveness of continuous loco-regional analgesic application (ropivacaine) through surgically placed Intercostal Catheter (ICC) and to establish correctly this method as a possible…
- Trial name
- SPICA (NCT04939545)
- Testing
- Ropivacain, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University Hospital, Basel, Switzerland
Venous Thromboembolism, Thoracic Surgery
Incidence of Venous Thromboembolism in Patients Undergoing Major Esophageal Resection
The purpose of this study is to determine the incidence of post-operative venous thromboembolism (VTE) in patients undergoing major esophageal resection for malignancy.
- Conditions
- Venous Thromboembolism, Thoracic Surgery, Esophageal Cancer
- Trial name
- NCT03115541
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 187 people
- Sponsor
- McMaster University
Non-small Cell Lung Cancer Stage IIIA
Erlotinib Versus Vinorelbine/Cisplatin as Adjuvant Treatment in Stage IIIA NSCLC Patients With EGFR Mutations
The purpose of this study is to assess the effect and safety of erlotinib versus NVB plus cisplatin (NP) as adjuvant treatment in patients with stage IIIA NSCLC after complete resection with EGFR activating mutations and to…
- Trial name
- NCT01410214
- Testing
- Erlotinib, vinorelbine/cisplatin
- Where
- 11 sites in China
- Volunteers
- 80 people
- Sponsor
- Chinese Lung Cancer Surgical Group
Diaphragm Injury, Phrenic Nerve Paralysis
Measurement of Diaphragmatic Dysfunction After Thoracic Surgery
This study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of…
- Conditions
- Diaphragm Injury, Phrenic Nerve Paralysis, Thoracic Cancer, Postoperative Complications
- Trial name
- NCT04507594
- Testing
- Lung lobectomy OR esophagus cancer resection
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
Pulmonary Nodules, Lung Neoplasms
Non-intubated Versus Intubated Anesthesia for Thoracoscopic Sublobar Resection
This is a large clinical study that compares two different types of anesthesia for patients undergoing a specific kind of minimally invasive lung surgery (thoracoscopic sublobar resection) to remove small, early-stage lung…
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Thoracic Surgery
- Trial name
- NIVA-TSLR (NCT07395375)
- Testing
- Non-intubated Anesthesia, Conventional Intubated General Anesthesia, Laryngeal Mask Airway (LMA)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection
Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection, Segmentectomy, Lobectomy of the Lungs
- Trial name
- NCT07603921
- Testing
- Pre-incisional infiltration with ropivacaine plus triamcinolone, Pre-incisional infiltration with ropivacaine alone
- Where
- China
- Volunteers
- 346 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Pain
Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection
Since VAT bears with it severe postopearive pain, and since ketamine has been shown to be an optimal analgesics adjuvant for postoperative pain, we wish to assess to effects of ketamie vs.
- Trial name
- NCT00822133
- Testing
- lidocaine, ketamine, non-active drug cream
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Non-small Cell Lung Cancer
Complication and Lung Function Impairment Prediction Using Perfusion and CT Air Trapping
The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for predicting post-operative forced expiratory volume in 1 second (FEV1) values for lung resection candidates; this new model will be…
- Trial name
- CLIPPCAIR (NCT03885765)
- Testing
- Predictive data, Lung resection
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Montpellier
Non Small Cell Lung Cancer, Complete Surgical Resection
Using ctDNA to Determine Therapies for Lung Cancer
This is a study to look at whether the presence of circulating tumour DNA (ctDNA) in the blood can help to predict whether giving adjuvant treatment after surgery can decrease the chance of the cancer coming back in people with…
- Conditions
- Non Small Cell Lung Cancer, Complete Surgical Resection, Circulating Tumor DNA
- Trial name
- ctDNA Lung RCT (NCT04966663)
- Testing
- Nivolumab, Pemetrexed, Gemcitabine
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University Health Network, Toronto
Lung Cancer, Ventricular Failure, Right
Right Side of Heart Function After Lung Surgery
The purpose of this study is explore the impact of lung cancer surgery on the function of the right side of the heart.
- Trial name
- NCT01892800
- Testing
- Lung resection
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Glasgow
Lung Cancer, Lung Tumor
NeoMend ProGEL™ Pleural Air Leak Sealant Post-Approval Study
The purpose of this post approval study is to further characterize the safety profile of the ProGEL™ Pleural Air Leak Sealant in commercial use, with specific reference to long-term safety over 90 days of follow-up.
- Trial name
- NCT01394978
- Testing
- Control, ProGEL Pleural Air Leak Sealant with standard surgical closure, ProGEL Pleural Air Leak Sealant without standard surgical closure
- Where
- 18 sites in United States
- Volunteers
- 444 people
- Sponsor
- C. R. Bard
Pulmonary Resection Surgery
Effect of Vibratory Expiratory Pressure on Pulmonary Function After Lung Resection Surgery
Postoperative airway clearance and recovery of pulmonary function after lung resection is critical in patients undergoing pulmonary resection surgery.
- Trial name
- NCT01826136
- Testing
- Acapella device
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Hospital
Liver Disease, Pulmonary Embolism
Pulmonary Embolism After Liver Resection
Major surgery is associated with a postoperative hypercoagulable state related to the surgical trauma that may lead to thromboembolic complications.
- Conditions
- Liver Disease, Pulmonary Embolism, Thrombophilia, Death
- Trial name
- NCT01486511
- Testing
- Liver resection, Computed Tomography
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Beaujon Hospital
Thoracic Neoplasms
Post-operative Medium Chain Triglyceride Diet May Reduce Hospital Stay Following Lung Resection
Lung resection, a critical treatment for various thoracic diseases, including lung cancer, often necessitates prolonged hospitalization due to rare but severe postoperative complications such as chyle leaks, with an occurrence of…
- Trial name
- NCT07159659
- Testing
- MCT Diet
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- Chinese University of Hong Kong
Postoperative Air Leak, Lung Resection
Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema
Prolonged air leak is reported in up to 60 to 75% of patients after lung operation in the presence of severe lung emphysema. The effect of the non-powered AEONTM Endostapler as compared to the Echelon FlexTM Powered plus stapler…
- Trial name
- Stapler (NCT05628415)
- Testing
- Non-powered AeonTM Endostapler (according to manufacturer medical device classification IIb), Echelon FLEX™ Powered plus Stapler (according to manufacturer medical device classification IIb)
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- University Hospital, Basel, Switzerland