Clinical trials: Post Stroke, open to volunteers
Stroke, Acute, Dysphagia
Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia.
BACKGROUND: Dysphagia is one of the most life-threatening stroke complications. Dysphagic stroke patients are at increased risk of aspiration pneumonia.
- Conditions
- Stroke, Acute, Dysphagia, Pneumonia
- Trial name
- NCT06123650
- Testing
- Repetitve transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Stroke, Aphasia Following Cerebral Infarction
Combined Aphasia and Robot-Assisted Arm Treatment for Chronic Stroke Survivors
The goal of this clinical trial is to learn if a program that combines language and arm treatment can improve language and movement problems in people with chronic stroke.
- Conditions
- Stroke, Aphasia Following Cerebral Infarction, Hemiparesis After Stroke
- Trial name
- CARAT (NCT07000019)
- Testing
- CARAT: combined aphasia and robot-assisted arm therapy, Robot-assisted arm therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York Medical College
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Post-Stroke Fatigue
Graded Activity Training and Task- Oriented Training on Post-Stroke Fatigue
The aim of this randomized controlled trial is to determine the effects of Graded Activity Training and Task Oriented Training on Fatigue in Post-Stroke Patients.
- Trial name
- NCT06846177
- Testing
- Graded Activity Training, Task-Oriented Training
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Stroke
Hybrid Robot+FES Stroke Rehabilitation
The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle…
- Trial name
- NCT04550728
- Testing
- Ankle robot training group, Ankle robot training and functional electrical stimulation(FES) group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Ischemic Stroke, Acute
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Through a multicenter prospective AIS cohort study, we analyze the potential association of human proteome, microbiome and metabolome alterations with AIS prognosis, searching for key proteins, differential organisms and…
- Trial name
- NCT06584565
- Testing
- microbiome; metabolomics; proteomics
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Stroke
Real-time Personalized Brain State-dependent TMS After Stroke
Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic upper extremity function after stroke.
- Trial name
- NCT06533176
- Testing
- Personalized brain state-dependent single-pulse TMS
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Sara Hussain
Stroke, Ischemic
Effects of Gastrostomy and Oral Tube Feeding on Patients With Dysphagia After Stroke
The goal of this clinical trial is to compare the differences in swallowing function, quality of life and nutritional status between ischemic stroke patients with dysphagia using Intermittent Oro-esophageal Tube and Gastrostomy.
- Trial name
- NCT06818513
- Testing
- routine rehabilitation therapy, Gastrostomy, Oral tube feeding
- Volunteers
- 150 people
- Sponsor
- Muhammad
Acute Ischemic Stroke
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke).
- Trial name
- TENACITY (NCT07361302)
- Testing
- Tenecteplase, Standard of care treatment
- Where
- 257 sites in Argentina, Australia and 14 more
- Volunteers
- 1,325 people
- Sponsor
- Boehringer Ingelheim
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Ischemic, Stroke Hemorrhagic
The REACTplusNMES Trial: A Double-blinded RCT
The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biomechanical, clinical…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Cerebrovascular
- Trial name
- REACT+NMES (NCT06127602)
- Testing
- Reactive balance training with Neuromuscular Electrical Stimulation, Reactive balance training without Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Illinois Chicago
Stroke, Hypertension
BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement
The investigators want to improve care for people who have had a stroke. High blood pressure is the leading cause for having a second stroke and can lead to poor brain health.
- Conditions
- Stroke, Hypertension, Home Blood Pressure Monitoring, Implementation Research
- Trial name
- BRIDGE (NCT07091851)
- Testing
- Group medical visits and home blood pressure monitoring
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Stroke
Effect of Cerebellar Fastigial Nucleus Stimulation Combined With Sling Exercise on Motor Function in Hemiplegic Stroke Patients
This study aims to investigate the rehabilitative effects and synergistic potential of combining Fastigial Nucleus Stimulation (FNS) with Sling Exercise Training (SET) on motor function in patients with post-stroke hemiplegia.
- Trial name
- NCT07670936
- Testing
- Cerebellar Fastigial Nucleus Electrical Stimulation, Sling Exercise Therapy
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shengjing Hospital
Stroke
Development of a Genomics-based Multimodal Prediction Model for Post-stroke Vascular Dementia
To collect large-scale multimodal data, including genomic information, neuroimaging, neurophysiological measures, cognitive assessments, and clinical characteristics from stroke survivors and healthy controls.
- Trial name
- NCT07660263
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Seyoung Shin
Post-induction Hypotension, Intestinal Obstruction
SV and IVC Collapsibility Index to Predict Postinduction Hypotension
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow…
- Trial name
- NCT07742904
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Stroke, Stroke (6 Months or More After Onset)
Co-Designed Digital Education and Peer Support for Young and Middle-Aged Stroke Survivors
Stroke survivors often experience persistent unmet needs during long-term recovery. Young and middle-aged stroke survivors may face additional challenges in balancing rehabilitation with work and family responsibilities.
- Trial name
- NCT07725666
- Testing
- Patient-Centered Digital Education and Peer Support Program, Usual Post-Stroke Care
- Volunteers
- 148 people
- Sponsor
- Chang Gung Memorial Hospital
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset
This study aims to evaluate the efficacy and safety of tenecteplase (TNK) intravenous thrombolysis within the extended time window (4.5 to 24 hours) in patients with acute posterior circulation ischemic stroke.
- Trial name
- NCT07094763
- Testing
- TNK plus standard medical treatment, standard medical management
- Where
- China
- Volunteers
- 406 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Cerebral Small Vessel Disease, Stroke
Cerebral Small Vessel Disease Progression Dependent on Stroke Type
The goal of this prospective, observational study is to understand if cerebral small vessel disease (CSVD) has different velocities and patterns of temporal development, dependent on a concurrent ischemic stroke.
- Conditions
- Cerebral Small Vessel Disease, Stroke, Stroke Recurrence, Biomarkers
- Trial name
- ZMA_BIO (NCT07611136)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Johannes Dorst