Clinical trials: Post Traumatic Stress
Posttraumatic Stress Disorder, Depression
Examining Changes in Microbiota Over the Course of PTSD Treatment
The overall goals of this project are to evaluate the use of 5-day intensively-delivered Cognitive Processing Therapy to treat PTSD and to determine the associations between the microbiome, salivary cytokines, and the presence of…
- Trial name
- NCT04109196
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Rush University Medical Center
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Posttraumatic Stress Disorder, Substance Abuse
Multicomponent Cognitive Behavioral Therapy(CBT) for Posttraumatic Stress Disorder (PTSD) and Substance Abuse
Purpose: To conduct a pilot study of a cognitive-behavioral treatment (CBT) for PTSD and substance abuse among persons with serious mental illness (SMI) treated in a community setting.
- Trial name
- PTSD/SUD (NCT01029197)
- Testing
- CBT and exposure therapy for PTSD, Treatment as Usual
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder, Generalized Anxiety Disorder
The Modular Protocol for Mental Health (MPMH)
Currently, our best psychological treatments for anxiety and mood disorders only focus on individual diagnoses. So, there are separate treatments for Panic Disorder, or Depressive Disorder, or Social Anxiety, etc.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder, Social Anxiety Disorder
- Trial name
- MPMH (NCT03143634)
- Testing
- The Modular Protocol for Mental Health, Treatment-as-usual
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
PTSD, Panic Attacks
Exposure Therapy for Veterans With PTSD and Panic Attacks (Phase 1)
To evaluate the feasibility, acceptability and effectiveness of Multiple Channel Exposure Therapy-Veterans (MCET-V) as a treatment for returning service members with comorbid posttraumatic stress disorder (PTSD) and panic…
- Trial name
- NCT01551199
- Testing
- Multiple Channel Exposure Therapy- Veterans
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Sleep Initiation and Maintenance Disorders, Stress Disorders, Posttraumatic
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress
Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances.
- Trial name
- NCT03642028
- Testing
- Suvorexant
- Where
- 4 sites in United States
- Volunteers
- 190 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Insomnia
Stress, Sleep and Cardiovascular Risk
We are evaluating a model where trauma exposure and threatening environments elicit nocturnal vigilance and sleep-related fears that compromise the healthy reduction of autonomic arousal during sleep which in turn stimulates…
- Trial name
- NCT03487991
- Testing
- Personalized sleep intervention
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Howard University
Post-Traumatic Stress Disorder
Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder
The primary purpose of this study is to investigate the efficacy of neurofeedback (NF) of real-time functional magnetic resonance imaging (rt-fMRI) data of the amygdala with regards to the reduction of post-traumatic stress…
- Trial name
- PTSD (NCT03574974)
- Testing
- Experimental Feedback, Control Feedback
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Yale University
PTSD, Post Traumatic Stress Disorder PTSD
Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)
The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in…
- Conditions
- PTSD, Post Traumatic Stress Disorder PTSD, PTSD - Post Traumatic Stress Disorder, Post Traumatic Stress Disorder
- Trial name
- NCT07523685
- Testing
- non-invasive vagus nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Acacia Clinics
Post Traumatic Stress Disorder
Early Prevention of Post Traumatic Stress Disorder
Sunnybrook Health Sciences Centre is Canada's largest trauma centre, treating 1,100 patients annually. A traumatic experience can lead to post-traumatic stress disorder, which increases hospital stays, emergency visits and…
- Trial name
- NCT02004743
- Testing
- Intervention, Treatment as usual
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pelvic Pain, Stress Disorders, Traumatic
Restoring Emotional, Sexual, and Physical Empowerment Through CBT & Trauma-sensitive Care: A Chronic Pelvic Pain Intervention
This project will develop and preliminarily examine RESPECT, a trauma-sensitive psychological and physical therapy intervention to treat chronic pelvic pain, posttraumatic stress symptoms (PTS), and dysfunctional sexual behavior…
- Trial name
- RESPECT (NCT02588885)
- Testing
- Trauma-sensitive Care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rush University Medical Center
Posttraumatic Stress Disorder, Alcohol Use Disorders
CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders
The proposed study will examine the efficacy of doxazosin in the treatment of PTSD and alcohol use disorder or substance use disorders.
- Trial name
- Doxazosin (NCT02500602)
- Testing
- doxazosin
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder (AUD), PTSD
PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
This study is a phase 2 single-site, double-blind, placebo-controlled, randomized clinical trial with an open-label extension phase to examine the safety of psilocybin (25 mg) combined with psychological support (Psi-PS) for…
- Trial name
- Psi-PS (NCT06853912)
- Testing
- Psilocybin 25 mg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nathan Brashares Sackett
Post Traumatic Stress Disorder
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder
The study evaluates the effect of hyperbaric oxygen therapy on veterans with combat-associated PTSD in an double blind sham control study.
- Trial name
- HBOT (NCT04518007)
- Testing
- hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 56 people
- Sponsor
- Assaf-Harofeh Medical Center
Spinal Cord Injuries, PTSD
Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an…
- Conditions
- Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
- Trial name
- NCT05233111
- Testing
- Brief Prolonged Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute
Post-traumatic Stress Disorder
Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.
- Trial name
- REDUCTRAUMA2 (NCT01713556)
- Testing
- Propranolol, Trauma reactivation
- Where
- 4 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
PTSD, Substance Use Disorders
Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
With this research, the investigators hope to learn if cognitive behavioral therapy (CBT) for posttraumatic stress disorder (PTSD) works in people who have both PTSD and problems with drugs or alcohol.
- Trial name
- CBT (NCT01357577)
- Testing
- Cognitive behavioral therapy for PTSD
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
PTSD
The Efficacy of KIDNET in the Treatment of Traumatized Refugee Children in Germany
The purpose of the study is to assess the effectiveness of KIDNET in treating traumatized refugee children in Germany
- Trial name
- NCT00559000
- Testing
- KIDNET
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University of Konstanz
PTSD
Changes in Digital Phenotype During PE Therapy
PTSD is characterized by physiological changes, some of which are thought to be chronic, while others are observed in response to stressogenic stimuli.
- Trial name
- NCT04056767
- Volunteers
- 100 people
- Sponsor
- Nadav Goldental
Post-traumatic Stress Disorder
Qualitative Study on the Perception of Changes in the Psychotherapy of Traumatized Young People
The clinic of psychological trauma in adolescents still requires further development, whereas it is well documented in adults. This clinic is complex, because it must take into account the nature and type of trauma (recent or…
- Trial name
- TRAUMADOPSY (NCT06138522)
- Testing
- Semi-structured interviews, Child Post-Traumatic Stress Response Index (CPTS-RI) scale, - Therapeutic Alliance Questionnaire (HAQ-CP)
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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