Clinical trials: Post Traumatic Stress
Intrusive Negative Thinking
Intervention for Intrusive Negative Thinking
Intrusive negative thinking styles such as rumination are typical of many psychiatric disorders, are difficult to treat, and predict poor treatment outcome.
- Trial name
- NCT02394704
- Testing
- Sensory attention training
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of Pittsburgh
PTSD - Post Traumatic Stress Disorder, TBI-Traumatic Brain Injury
Adaptation of the STAIR-NT for First Responders
This study is a randomized controlled pilot examining the implementation of an adapted intervention, Skills Training in Affective and Interpersonal Regulation-Narrative Therapy (STAIR-NT), among a first responder population with…
- Trial name
- NCT07212140
- Testing
- Adapted STAIR-NT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Florida State University
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Implantable Defibrillator User, Stress Reaction
Self-Management Interventions After an ICD Shock
This study, "Biobehavioral Intervention to Reduce PTSD Symptoms After an ICD Shock," addresses a critical need in cardiology care by describing the feasibility and acceptability of a timely, highly promising…
- Conditions
- Implantable Defibrillator User, Stress Reaction, Ptsd, Stress Management
- Trial name
- NCT06037785
- Testing
- Self-Paced Self-Management (SPSM)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Stress, Psychological, Post-traumatic Stress
Wellbeing and Stress Among Mobile Phone Dispatched Lay Responders
The aim of this study is to provide detailed information on state of mind, psychological wellbeing and stress for lay responders dispatched to suspected OHCA via a mobile phone application.
- Trial name
- NCT04165668
- Testing
- Exposure: First on scene
- Where
- 2 sites in Sweden
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Stress Disorders, Post-Traumatic, Depression
EMDR Versus Imagery Rescripting for Trauma-Related Intrusions
The goal of this clinical trial is to investigate the effectiveness and mechanisms of action of trauma treatments in a sample of patients meeting criteria for posttraumatic stress disorder (PTSD), unipolar depression, or both…
- Trial name
- NCT06215313
- Testing
- Eye Movement Desensitization and Reprocessing, Imagery Rescripting
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Geestelijke Gezondheidszorg Eindhoven (GGzE)
TBI
A Brief Educational Intervention to Improve Traumatic Brain Injury (TBI) Screening Outcomes
This research study is designed to learn about Veterans' understanding of mild TBI (traumatic brain injury) and the VA TBI screening process.
- Trial name
- TBI (NCT01558791)
- Testing
- TBI handout
- Where
- 5 sites in United States
- Volunteers
- 1,236 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder
Feasibility of an Intervention for Somatic Flashbacks in PTSD
This trial will explore the feasibility and acceptability of an intervention for Somatic flashbacks in Post-Traumatic Stress Disorder (PTSD). Imagery Rescripting (ImRs) will form a central part of the intervention.
- Trial name
- NCT05996913
- Testing
- Imagery rescripting
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University College, London
PTSD
The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without…
- Trial name
- NCT06144203
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Schizophreniform Disorders, Bipolar Disorder
REWRITALIZE Your Recovery - Evaluation of a Creative Writing Group Intervention
Health institutes call for psychosocial interventions and recovery-oriented approaches as supplement to pharmacological treatment for mental health disorders.
- Conditions
- Schizophreniform Disorders, Bipolar Disorder, Severe Depression, Ptsd
- Trial name
- REWR (NCT06251908)
- Testing
- Rewritalize, Standard mental health care
- Where
- 6 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Amager Hospital
PTSD
Complementary and Alternative Interventions for Veterans With Posttraumatic Stress Disorder
The overarching aim of this proposal is to research whether meditation-based treatments are effective in decreasing posttraumatic stress disorder (PSTD) symptoms in veterans, which complementary and alternative (CA) treatments…
- Trial name
- NCT01512303
- Testing
- Sudarshan Kriya Yoga, Mindfulness-Based Stress Reduction
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nightmares, Stress Disorders, Post-Traumatic
Understanding Trauma Nightmares Using In-Home Measurement
Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide.
- Conditions
- Nightmares, Stress Disorders, Post-Traumatic, Actigraphy, Respiratory Sinus Arrhythmia
- Trial name
- NCT03974503
- Testing
- Exposure, Relaxation, and Rescripting Therapy, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack
This randomized controlled trial evaluates efficacy of combined prolonged exposure (PE) and the selective serotonin reuptake inhibitor (SSRI) paroxetine in the treatment of survivors of the World Trade Center (WTC) attacks.
- Trial name
- NCT01130103
- Testing
- Paroxetine, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Stress Disorder
Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission tomography (PET) sleep…
- Trial name
- REM-P (NCT00871650)
- Testing
- Sleep data recording, PET scan - waking, PET scan - REM Sleep
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Post-Traumatic Stress Disorder
Biopsychosocial Effectiveness of Exercise Trainings in Earthquake Survivors With Post-Traumatic Stress Disorder
In study, the investigators aim to demonstrate the effectiveness of biopsychosocial-based exercise approach in post-traumatic stress disorder of physiotherapists in post-earthquake disaster management.
- Trial name
- NCT06390618
- Testing
- Aerobic Exercise (AE) Group, Combined Exercise (CE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Erkin Oğuz SARI
PTSD
Precise Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder
The purpose of this study is to investigate the efficacy and safety of repetitive transcranial magnetic stimulation under precise localization for post-traumatic stress disorder
- Trial name
- NCT05544110
- Testing
- Active transcranial magnetic stimulation
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Xijing Hospital
PTSD, Cardiac Arrest
Stellate Ganglion Blockade to Reduce Cardiac Anxiety and PTSD Symptoms in Cardiac Arrest Survivors
This is a pilot randomized controlled trial (RCT) to gain preliminary evidence regarding the acceptability, tolerability, safety, and efficacy of a combined intervention of Stellate Ganglion Blockade (SGB) and psychoeducation on…
- Conditions
- PTSD, Cardiac Arrest, Anxiety and Fear, Sleep Disturbance
- Trial name
- SGB-PsychoED (NCT04582396)
- Testing
- stellate ganglion block injection, Normal saline injection, Psychoeducation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Posttraumatic Stress Disorder
Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD
The purpose of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with PTSD. The main question it aims to answer is: Do two open-label sessions of MDMA-assisted therapy reduce PTSD symptoms?…
- Trial name
- NUMCAP1 (NCT04968938)
- Testing
- midomafetamine, Therapy
- Sponsor
- Resilient Pharmaceuticals
Post Traumatic Stress Disorder
A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder
Therapy that uses Virtual Reality (VR) has been shown to help in the treatment of Post Traumatic Stress Disorder (PTSD). It is unclear what role the VR simulator itself plays in recovery.
- Trial name
- NCT00978484
- Testing
- Virtual Reality Exposure Therapy - Dynamic, Augmented Exposure Therapy
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- United States Naval Medical Center, San Diego
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