Clinical trials: Post Treatment Lyme Disease
Relapsing Fever, Tick-borne, Jarisch Herxheimer Reaction
Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever
Abstract Background Tick-Borne Relapsing Fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks.
- Trial name
- NCT00237016
- Testing
- doxycycline treatment
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Post-Lyme Disease Syndrome (PLDS)
Treating Post-Lyme Disease Syndrome With Acetogenins
To access the effectiveness of Acetogenins in treating Post-Lyme Disease Syndrome (PLDS).
- Trial name
- NCT04078841
- Testing
- ReaLife+ (RLP), Inert Brown powder
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Optimal Health Research
Post Treatment Lyme Disease Syndrome
Meditation and Stretching for Post Treatment Lyme Disease Syndrome
The investigators wish to conduct a preliminary study to examine the efficacy of meditation among patients with Post Treatment Lyme Syndrome (PTLDS).
- Trial name
- LMS (NCT02344537)
- Testing
- Kundalini Yoga
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Fatigue, Quality of Life
Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease
Approximately 10-20% of patients experience ongoing symptoms despite having received standard antibiotic therapy for Lyme disease.
- Trial name
- NCT03891667
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Post-Treatment Lyme Disease
Transcranial Direct Current Stimulation for Post Treatment Lyme Disease
The primary purpose of this pilot study is to investigate a novel approach to the treatment of cognitive symptoms that persist despite prior antibiotic treatment for Lyme disease (Post treatment Lyme Disease or PTLD).
- Trial name
- NCT06915324
- Testing
- Transcranial Direct Current Stimulation (tDCS), Cognitive training
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Lyme Disease
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease
Lyme disease is the most common tick-borne disease in the United States. It is caused by the spirochete Borrelia burgdorferi. It may exist in a chronic form and be the result of: 1) persistent infection by B.
- Trial name
- NCT00000938
- Testing
- ceftriaxone, doxycycline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Erythema Migrans
Patient's Pretreatment Expectations About Post-Lyme Symptoms
The investigators will focus on pretreatment expectations of patients with early Lyme disease manifested as erythema migrans with the aim of assessing the association between pretreatment expectations quantified with a…
- Trial name
- NCT03462329
- Testing
- Antibiotics (preferentially oral doxycycline 100 mg bid)
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Lyme Disease
Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis
In this retrospective cohort study of patients with early Lyme neuroborreliosis (LNB), clinical and microbiologic characteristics and long-term outcome of definite vs.
- Trial name
- NCT04653558
- Where
- Slovenia
- Volunteers
- 311 people
- Sponsor
- University Medical Centre Ljubljana
Post-Treatment Lyme Disease
Meditation and Kundalini Yoga for Persistent Lyme-related Symptoms - an Online Study
This randomized, controlled study examines whether a daily practice over 8 weeks of Kundalini Yoga or Meditation can help to reduce pain and/or fatigue among patients with symptoms that persist despite prior antibiotic treatment.
- Trial name
- NCT04349605
- Testing
- Meditation, Kundalini Yoga
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Post-Treatment Lyme Disease
Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease
The goal of this clinical trial is to learn if an FDA approved drug, Ceftriaxone, given intermittently, can treat people between 18 and 75 years old with a history of Lyme disease, who are still experiencing persistent or…
- Trial name
- NCT06611111
- Testing
- Ceftriaxone (Rocephin®), Dextrose 5% (D5W)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- State University of New York - Upstate Medical University
Long Covid, Post-treatment Lyme Disease Syndrome
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This will be a pilot multi-arm clinical trial investigating the feasibility of Lumbrokinase (LK) as an intervention in three clinical cohorts: Long Covid (LC) Post-treatment Lyme disease syndrome (PTLDS) Myalgic…
- Conditions
- Long Covid, Post-treatment Lyme Disease Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
- Trial name
- NCT06511050
- Testing
- Lumbrokinase
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lyme Disease
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
This study will determine whether patients who have been infected with the Lyme bacteria, Borrelia burgdorferi, and treated with antibiotics still have the bacteria alive inside them and whether it is causing their symptoms.
- Trial name
- NCT00001539
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post-Treatment Lyme Disease, Chronic Lyme Disease
Effects of Psilocybin in Post-Treatment Lyme Disease
This study will examine the effects of psilocybin on Lyme disease symptom burden and quality of life in people with Post-Treatment Lyme Disease (PTLD).
- Conditions
- Post-Treatment Lyme Disease, Chronic Lyme Disease, Lyme Disease, Chronic
- Trial name
- NCT05305105
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Post-treatment Lyme Disease Syndrome, Chronic Pain
Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain
This study will investigate the effectiveness of the Sana Pain Reliever (Sana PR) at reducing chronic pain. The Sana PR is a device comprised of one main component (Mask with Earbuds) and two ancillary components (Charger and…
- Trial name
- NCT06655844
- Testing
- Sana Pain Reliever
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lyme Disease, Post Treatment Lyme Disease
Navigating Pregnancy and Parenthood With Lyme Disease
This is a mixed methods study exploring the experiences of pregnancy and parenting among participants with Lyme disease. Eligible participants will have been diagnosed with Lyme disease (LD), post-treatment Lyme disease syndrome…
- Conditions
- Lyme Disease, Post Treatment Lyme Disease, Chronic Lyme Disease, Tick-Borne Infections
- Trial name
- NCT06397794
- Testing
- Quantitative surveys and qualitative interview
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
Post-Treatment Lyme Disease
Tetracycline Treatment Tolerability Trial
Randomized, double-blind, placebo-controlled study (with a one-week washout period) where subjects receive either 3 months of tetracycline or 3 months of placebo.
- Trial name
- T-4 (NCT05219929)
- Testing
- Tetracycline 500 Mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Lyme Disease
Xenodiagnosis After Antibiotic Treatment for Lyme Disease
Background: The most common tick-borne illness in the United States, Lyme disease is caused by Borrelia burgdorferi bacteria that are transmitted to people by Ixodes scapularis ticks.
- Trial name
- NCT02446626
- Testing
- Skin biopsy, Blood draw, Xenodiagnosis
- Where
- 5 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post-Treatment Lyme Disease Syndrome
Ceftriaxone for Post-Treatment Lyme Disease
Lyme disease is a public health crisis in the US. It is estimated that over 400,000 cases occur every year with 10-20% of those infected going on to develop Post-Treatment Lyme disease Syndrome (PTLDS).
- Trial name
- NCT06785402
- Testing
- Ceftriaxone treatment
- Where
- United States
- Sponsor
- Hackensack Meridian Health