Clinical trials: Post-Acute COVID19 Syndrome
Long Covid19
Effectiveness of Testofen Compared to Placebo on Long COVID Symptoms
This is a double blind, randomised, placebo-controlled trial to evaluate orally-dosed Testofen (a specialised extract of Trigonella foenum-graecum (Fenugreek) seed) compared to placebo on post COVID-19 symptoms in otherwise…
- Trial name
- NCT05795816
- Testing
- Testofen, Microcrystalline cellulose
- Where
- Australia
- Volunteers
- 150 people
- Sponsor
- RDC Clinical Pty Ltd
Long COVID, Long Covid19
Symptom Tracking in Long COVID Patients Using Formula C™ Sublingual Drops
This is a digital symptom tracking study of Formula C™, a full cannabis flower formulation, rich in cannabinoids and terpenes, that has been shown to improve symptoms in people with Long COVID.
- Conditions
- Long COVID, Long Covid19, Post-Acute COVID-19, Post-Acute COVID-19 Syndrome
- Trial name
- NCT06163690
- Testing
- Endourage Targeted Wellness Formula C™, a full hemp flower extract
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endourage, LLC
Post-acute Infectious Syndrome (PAIS), Post-COVID-19 Condition (PCC or Long COVID)
Post-acute Infectious Syndrome - Aripiprazole Symptom Evaluation (PAIS-AriSE)
Post-acute infectious syndrome (PAIS), including post-COVID-19 condition (PCC or Long COVID), can develop after an infection and may cause persistent symptoms such as fatigue, problems with memory and concentration ("brain fog")…
- Trial name
- PAISE-AriSE (NCT07714213)
- Testing
- Aripiprazole (low-dose, 1mg)
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Christiana Franke
Chronic Fatigue Syndrome, COVID-19, Long Haul
Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation
This is a single-center, prospective, randomized, double-blind (pharmacotherapy), placebo-controlled, and comprehensive rehabilitation phase II clinical trial to determine the usefulness of pregabalin in a new indication…
- Trial name
- POSTCOVID (NCT05967052)
- Testing
- Pregabalin, Independent walking training, Gradual movement therapy in the ward
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
Post-COVID-19 Syndrome, Long COVID
ImPROving Quality of LIFe in the Long COVID Patient
The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with placebo/ritonavir to improve quality of life in non-hospitalized adult participants suffering from post-acute…
- Conditions
- Post-COVID-19 Syndrome, Long COVID, Long Covid19, COVID-19
- Trial name
- PROLIFIC (NCT05823896)
- Testing
- Nirmatrelvir/ritonavir
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Karolinska Institutet
Fatigue, Cognitive Deficit
Effects of PEA-LUT on Frontal Lobe Functions and GABAergic Transmission in Long-Covid Patients
The study explore the efficacy of PEA-LUT in patients suffering from neurological symptoms of Long-Covid
- Conditions
- Fatigue, Cognitive Deficit, COVID-19, Neurophysiologic Abnormality
- Trial name
- PL-PC19 (NCT05311852)
- Testing
- palmitoylethanolamide co-ultramicronized with antioxidant flavonoid luteolin (PEA-LUT)
- Where
- Italy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Department of Neurorehabilitation, Hospital of Vipiteno-Sterzing (BZ) Italy
Post-Acute COVID-19 Syndrome
Care for Veterans Post-COVID-19
The evidence-based Concordant Care approach involves engaging in processes that: 1) validate the patient's experience, 2) develop a shared understanding of the condition, and 3) create a patient-centered, whole health-oriented…
- Trial name
- NCT05787379
- Testing
- Concordant Care Training, Education Packet Training
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- VA Office of Research and Development
Long COVID
Amygdala Insula Retraining in the Management of Long COVID Symptoms
The goal of the study is to compare a mind body intervention against usual care in patients with fatigue with long COVID. Our research questions include 1. Is the mind body intervention additive to usual care in long COVID 2.
- Trial name
- NCT05851846
- Testing
- Amygdala insula retraining
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- Miami VA Healthcare System
Long COVID, Myocardial Injury
The Efficacy of Aerobic Exercise in the Rehabilitation of Patients With COVID-19-Related Myocardial Injury
A study of the efficacy of aerobic exercise based on cardiopulmonary exercise test in the rehabilitation of patients with COVID-19-related myocardial injury
- Trial name
- NCT06404411
- Testing
- Assigned interventions, conventional rehabilitation
- Volunteers
- 40 people
- Sponsor
- Chengdu Sport University
COVID-19
WHO COVID-19 - Evaluation of the Efficacy of Probiotics to Reduce the Occurrence of Long COVID
Probiotics may be considered as an option of treatment for long COVID since they have anti-viral effect, trigger immunomodulation and have low side-effects.
- Trial name
- PROVID-LD (NCT05080244)
- Testing
- Probiotics
- Where
- Canada
- Volunteers
- 618 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Coronavirus Disease 2019 (COVID-19), Post-Exposure Prophylaxis
Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers
Background: The rapid spread and high infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) makes identifying an effective prophylaxis agent highly important.
- Trial name
- NCT04438837
- Testing
- Hydroxychloroquine
- Where
- Israel
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Clinical Syndrome
Changes of NLF in Serum of Long COVID Patients
The study investigates the blood NFL levels in Long-COVID patients.
- Trial name
- NCT05060692
- Testing
- Bloot testing
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Post Acute COVID-19 Syndrome
Cognitive-behavioral Therapy for Mental Disorder in COVID-19 Survivors
The consequences of the Intensive Care Unit and the Covid-19 disease are still uncertain. However, many studies are bringing out often psychological and dramatic consequences for many COVID-survivor patients.
- Trial name
- LONGCOVID (NCT05815693)
- Testing
- mindfulness-based stress reduction (MBSR) and cognitive behavioral therapy (CBT)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lecco
COVID-19, Brain Fog
Transcranial Ultrasound Stimulation for Cognitive Function Modulation in Patients With Post COVID-19 Brain Fog
This study aims to investigate whether a specific brain region mediates the cognitive deficit in long COVID brain fog, and whether targeted modulation of this region can improve cognition.
- Conditions
- COVID-19, Brain Fog, Long COVID, Transcranial Ultrasound Stimulation
- Trial name
- NCT07154199
- Testing
- real transcranial ultrasound stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
PASC Post Acute Sequelae of COVID 19, Long COVID
From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19
Rationale: The diagnosis and pathogenesis of long COVID remains unknown. We have previously shown that [68Ga]FAPI Positron Emission Tomography-Computed Tomography (PET/CT) imaging shows potential for diagnosis and molecular…
- Conditions
- PASC Post Acute Sequelae of COVID 19, Long COVID, Long Covid-19, PASC
- Trial name
- LIBERATE (NCT06911476)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Post COVID-19 Condition (PCC), Dysfunctional Breathing
Dysfunctional Breathing in Post COVID-19 Condition.
The goal of this observational study with a cross-sectional design is to investigate what signs, symptoms and assessment which can describe and explain dysfunctional breathing in patients with post COVID-19 condition.
- Conditions
- Post COVID-19 Condition (PCC), Dysfunctional Breathing, Breathing Pattern Disorder, Post-Acute COVID-19 Syndrome
- Trial name
- DB-PCC (NCT06776263)
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Post-Acute COVID-19 Syndrome
Exercise Training Using an App on Physical Cardiovascular Function Individuals With Post-covid-19 Syndrome
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome.
- Trial name
- Recovery (NCT06168006)
- Testing
- Exercise, Control
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Nove de Julho
COVID-19, Long COVID
Study of Vascular Endothelial Glycocalyx and Ophthalmic Injury, Prospective Cohort of Patients With Prolonged Post-COVID-19 Symptoms
The glycocalyx is a membrane coat composed of glycoproteins attached to the surface of cell membranes. Recent publications have drawn attention to the potential role of a degradation of the endothelial glycocalyx (a kind of gel…
- Trial name
- GLYCOVLONG (NCT05235698)
- Testing
- Ophthalmological examinations, GlycoCheck
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Post-Acute COVID-19 Syndrome
Cognitive, Psychological, and Physical Functioning in Long-COVID Patients With Different Levels of Fatigue.
Post COVID-19 usually occurs 3 months from the onset of COVID-19 with symptoms that last for at least 2 months and cannot be explained by an alternative diagnosis.
- Trial name
- NCT05758558
- Where
- Belgium
- Volunteers
- 69 people
- Sponsor
- Hasselt University
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), HIV
COVID-19 Recovery Study: Symptoms and Biomarkers of Long COVID-19 in People Living With and Without HIV
This observational study will prospectively characterize the long-term symptoms and side effects of COVID-19 in cohorts of people living with and without HIV.
- Trial name
- NCT04958889
- Testing
- No intervention
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University