Clinical trials: Post-Acute COVID19 Syndrome
Post-COVID-19 Syndrome, Postural Tachycardia Syndrome
VNS for Long-COVID-19
The goal of this proposed clinical case series is to evaluate the effect of a non-invasive vagus nerve stimulation paradigm on: 1) Symptom reporting via validated patient reported outcomes, and 2) objective clinical biomarkers of…
- Conditions
- Post-COVID-19 Syndrome, Postural Tachycardia Syndrome, Dysautonomia
- Trial name
- NCT05630040
- Testing
- Non-invasive vagus nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Long COVID-19, Post-COVID-19 Syndrome
Long Term Impact of COVID-19
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has a devastating effect on human lives, including over 6.6 million death as of November 2022.
- Conditions
- Long COVID-19, Post-COVID-19 Syndrome, COVID-19
- Trial name
- NCT05813574
- Testing
- Observational patient reported outcomes
- Where
- Netherlands
- Volunteers
- 835 people
- Sponsor
- Medisch Spectrum Twente
Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome
Gene Sequencing as a Strategy for Identifying Genetic Factors Associated With Serious Adverse Events After Covid-19 Vaccines in Use in Brazil
This protocol proposes to investigate genetic factors that may be involved in the pathogenesis of adverse events of interest with selected covid-19 vaccines: vaccine-induced immune thrombotic thrombocytopenia, and neurological…
- Conditions
- Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome, Acute Disseminated Encephalomyelitis, Transverse Myelitis
- Trial name
- NCT05630313
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Long COVID Syndrome
A Fasting Pilot Study for Long COVID
Background Long COVID (LC) is a chronic multisystemic condition which substantially impact the quality of life. Despite the staggering burden of LC, there is still no effective treatment.
- Trial name
- NCT07418567
- Testing
- prolonged fasting
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Université de Sherbrooke
Neuro-PASC, Long COVID
Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans
Mental health symptoms, including cognitive impairment ("brain fog"), following COVID-19 are of great concern to Veterans. This research seeks to advance understanding of the long-term effects of COVID-19 on neuropsychiatric and…
- Trial name
- PASC (NCT06932237)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Vagus Nerve Diseases, Long COVID
Vagus Stimulation in Female Long COVID Patients.
The aim of the present pilot study is to investigate the acceptance, feasibility and implementation of the vagus nerv stimulation in Long COVID patients.
- Conditions
- Vagus Nerve Diseases, Long COVID, Long Covid19, Post-COVID-19 Syndrome
- Trial name
- Vagus (NCT05918965)
- Testing
- transcutaneous electrical vagal neurostimulation
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Post-COVID-19 Syndrome, Long COVID
Magnesium and Vitamin D Combination for Post-COVID Syndrome
The goal of this double-blind randomized controlled clinical trial is to determine the efficacy of the administration of magnesium chloride + vitamin D as an adjuvant in the treatment of post-Coronavirus Disease (COVID) syndrome.
- Conditions
- Post-COVID-19 Syndrome, Long COVID, Vitamin D Deficiency, Magnesium Deficiency
- Trial name
- NCT05630339
- Testing
- Magnesium chloride, Vitamin D
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Post-COVID-19 Syndrome
Telerehabilitation in the Post-COVID-19 Patient (TRIALS)
A major issue brought about by the current pandemic concerns the discontinuation of a large proportion of outpatient services provided locally, especially in the rehabilitation field.
- Trial name
- NCT05739552
- Testing
- Telerehabilitation program
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 30 people
- Sponsor
- Istituto Auxologico Italiano
Post-acute COVID-19 Syndrome
Education of Medical Staff to Post Acute Covid susTained sYmptoms
Evaluation of the effectiveness of a training and support intervention for general practitioners treating patients with persistent symptoms after a COVID-19 episode on the patients'quality of life at 3 months.
- Trial name
- EMPATY (NCT06082258)
- Testing
- Training in the management of functional disorders, Reimbursement of 3 long consultations
- Where
- 7 sites in France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, SARS-CoV-2
Biomarkers for Post-COVID Conditions
The COVID-19 infection affects humans differently. While some recover quickly and fully, others develop serious illnesses and late complications.
- Conditions
- COVID-19, SARS-CoV-2, Biomarkers, Post-acute COVID-19 Syndrome
- Trial name
- NCT05196516
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Post-COVID-19 Syndrome
Biomarker Analysis in Post-COVID Patients
Headache is one of the most common neurological manifestations of COVID-19. However, it is unclear whether chronic headache after the initial diagnosis, is associated with ongoing damage of the central nervous system.
- Trial name
- NCT05836428
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Tinnitus, Subjective
Treatment for Post Acute COVID-19 Syndrome
Post-acute COVID-19 tinnitus has not been treated successfully. As tinnitus may be related to SARS-CoV-2 neurological manifestations.
- Trial name
- NCT05507372
- Testing
- Pimozide 1 MG
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Applied Biology, Inc.
SARS CoV-2 Post-Acute Sequelae
Long-Term Study of COVID-19 Infection and Long COVID
This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19.
- Trial name
- PASC (NCT07781501)
- Testing
- This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms.
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of North Carolina, Chapel Hill
Long COVID
A Study to Assess Anktiva in Patients With Long Covid-19.
This study will test the safety and tolerability of Anktiva in patients with Long Covid. Eligible patients will receive up to 2 doses of Anktiva and have follow-up exams and tests.
- Trial name
- INTERRUPT_LC (NCT07108036)
- Testing
- N-803 (IL-15 Superagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ImmunityBio, Inc.
Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
This study investigates a non-pharmacological treatment approach for Postural Orthostatic Tachycardia Syndrome (POTS), a disorder of the autonomic nervous system characterized by an excessive increase in heart rate upon standing.
- Trial name
- NCT06996314
- Testing
- TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB)
- Volunteers
- 100 people
- Sponsor
- Ali Kapan
Post-Acute COVID-19, Post COVID-19 Condition
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
- Conditions
- Post-Acute COVID-19, Post COVID-19 Condition, Post Viral Fatigue, Dyspnea
- Trial name
- PASC VQ (NCT05866952)
- Testing
- Computed Tomography of the Chest
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Long COVID
Effect of Lithium Therapy on Long COVID Symptoms
This study will assess low-dose lithium's effects on several different symptoms experienced by long COVID patients.
- Trial name
- NCT05618587
- Testing
- Lithium
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- State University of New York at Buffalo
Depression, Post-COVID-19 Syndrome
Evaluation of DEPREXIL in Patients With Clinical Depression Through Psychological and Neuroendocrine Assessment
Clinical depression is a mood disorder that affects people of all ages with symptoms such as sadness, anger or frustration, appetite changes, difficulty concentrating and suicidal thoughts.
- Conditions
- Depression, Post-COVID-19 Syndrome, Depression Mild, Depression Moderate
- Trial name
- NCT06496087
- Testing
- DEPREXIL
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Catalysis SL
Post-Acute COVID-19 Syndrome
REVERSE-Long COVID-19 With Baricitinib Study
REVERSE-LC is a phase 3 trial of baricitinib versus placebo in adults with neurocognitive impairment (a form of Alzheimer's Disease and Related Dementias or ADRD) or cardiopulmonary symptoms due to Long COVID.
- Trial name
- REVERSE-LC (NCT05858515)
- Testing
- Baricitinib 4 MG
- Where
- 6 sites in United States
- Sponsor
- Vanderbilt University Medical Center
Covid19, Post Viral Fatigue
Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of Post-Coronavirus-19 Fatigue
Preliminary research from our group indicates that up to half of COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one third of those…
- Trial name
- TROPIC (NCT05027724)
- Where
- Ireland
- Volunteers
- 108 people
- Sponsor
- University of Dublin, Trinity College