Clinical trials: Post-Acute COVID19 Syndrome
Long COVID
Prospective, Open-label Study of Seraph 100 in Patients With Prolonged COVID (PC)
This study will use a prospective, open, single-arm design, in which a group of 100 patients with a diagnosis of prolonged COVID, previously selected according to inclusion and exclusion criteria, and who have undergone informed…
- Trial name
- NCT06637800
- Testing
- Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100)
- Where
- Mexico
- Sponsor
- ExThera Medical Corporation
Postural Orthostatic Tachycardia Syndrome (POTS), Post-acute COVID-19 Syndromes
Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With Postural Orthostatic Tachycardia Syndrome.
This study investigates a non-pharmacological treatment approach for Postural Orthostatic Tachycardia Syndrome (POTS), a disorder of the autonomic nervous system characterized by an excessive increase in heart rate upon standing.
- Trial name
- NCT06996314
- Testing
- TVNS + Slow-Paced Breathing (TVNS+SDB), TVNS without Breathing Training (TVNS+NB)
- Volunteers
- 100 people
- Sponsor
- Ali Kapan
Long COVID, Long COVID-19
AT1001 for the Treatment of Long COVID
The primary objective of this study is to evaluate the safety and efficacy of Larazotide (AT1001) versus placebo in children and adults 7 to ≤50 years of age who present with symptoms of Long COVID in the presence of SARS-CoV-2…
- Conditions
- Long COVID, Long COVID-19, Post Acute COVID-19 Syndrome, Post Acute Sequelae of COVID-19
- Trial name
- NCT05747534
- Testing
- Larazotide Acetate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Massachusetts General Hospital
Long COVID
Clinical and Biological Characterization of Post COVID-19 Syndrome
The goal of this observational study is to describe the symptoms that persist for more than 12 weeks after the acute episode in participants who had COVID-19, and compare the functional, socioeconomic and occupational effects…
- Trial name
- NCT05735782
- Testing
- Clinical, mental health and psychosocial profile of Post-COVID-19 syndrome, Diagnostic performance of echocardiographic and biological markers in Post-COVID-19 syndrome
- Where
- Argentina
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Arturo Jauretche National University
Post COVID-19 Condition, Long COVID
Pycnogenol® in Post-COVID-19 Condition
To determine the effect of Pycnogenol® versus placebo on patient-reported health status in people with post COVID-19 condition.
- Trial name
- PYCNOVID (NCT05890534)
- Testing
- Pycnogenol®
- Where
- Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Post COVID-19 Condition, Post-COVID-19 Syndrome
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
Over 500 million people have been infected with COVID-19, and to date, more than 6 million people have died. Many individuals who have recovered from COVID-19 continue to experience symptoms even after they have been "cured" of…
- Conditions
- Post COVID-19 Condition, Post-COVID-19 Syndrome, Post-COVID Syndrome, COVID-19
- Trial name
- PCS-HBOT (NCT06082518)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device).
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Long COVID
Characterization of the Immunometabolic Signature in Long COVID-19.
The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC).
- Trial name
- LoCo-ImMet (NCT05758480)
- Testing
- Blood sample (at inclusion and 6 months later), Patient questionnaires (at inclusion and 6 months later)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Post COVID-19 Condition
Bright Light Therapy for Post-COVID-19 Fatigue
This is a randomized placebo-controlled trial to examine the efficacy of two-week bright light therapy for patients with post-COVID-19 fatigue.
- Trial name
- NCT05677932
- Testing
- Bright light therapy, Dim red light therapy
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Chinese University of Hong Kong
Persistent COVID-19, B Cell Malignancies
Evaluation of Prevalence and Risk Factors of Persistent COVID-19 in Immunocompromised Patients
Spontaneous international multicenter retrospective and prospective observational study which objective is to evaluate the prevalence and risk factors of persistent SARS-CoV-2 infection within a population of hematology patients…
- Trial name
- PERsiCO (NCT06576102)
- Testing
- Persisting SARS-CoV-2 infection
- Where
- 5 sites in Italy, Spain
- Volunteers
- 204 people
- Sponsor
- Maddalena Giannella
Post-COVID ME/CFS
Study to Investigate Improvement in Physical Function in SF-36 With Vericiguat Compared With Placebo in Participants With Post-COVID-19 Syndrome
The goal of this clinical trial is to evaluate the therapeutic value of an approved drug (Vericiguat) in patients with post-COVID-19 syndrome, who suffer from profound tiredness or fatigue, regardless of bed rest.The main…
- Trial name
- NCT05697640
- Testing
- Vericiguat Oral Tablet
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Long COVID
Tele-exercise Training Program for Long COVID
Patients with long coronavirus disease (COVID-19) experience multisystem symptoms and reduced quality of life (QOL). Proactive interventions are needed to enhance health outcomes.To investigate the effects of a 12-week…
- Trial name
- NCT07553897
- Testing
- Telehealth exercise training program, Education and self-exercise
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Long COVID-19, Post-COVID-19 Syndrome
Long Term Impact of COVID-19
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has a devastating effect on human lives, including over 6.6 million death as of November 2022.
- Conditions
- Long COVID-19, Post-COVID-19 Syndrome, COVID-19
- Trial name
- NCT05813574
- Testing
- Observational patient reported outcomes
- Where
- Netherlands
- Volunteers
- 835 people
- Sponsor
- Medisch Spectrum Twente
Long COVID
A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults with Long COVID.
This decentralized trial is a Phase 2, 1:1 randomized, double-blind, superiority, placebo-controlled study in an anticipated 100 non-hospitalized highly symptomatic adult participants with long COVID.
- Trial name
- NCT05668091
- Testing
- Nirmatrelvir, Ritonavir
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Harlan M Krumholz
Covid19, Post Viral Fatigue
Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of Post-Coronavirus-19 Fatigue
Preliminary research from our group indicates that up to half of COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one third of those…
- Trial name
- TROPIC (NCT05027724)
- Where
- Ireland
- Volunteers
- 108 people
- Sponsor
- University of Dublin, Trinity College
Long COVID, Post-Acute Sequelae of COVID-19
Mind Body Intervention for Long COVID-19
The goal of this study is to determine if a mind-body intervention can help people suffering from symptoms associated with Long COVID.
- Conditions
- Long COVID, Post-Acute Sequelae of COVID-19, COVID Long-Haul
- Trial name
- NCT06045338
- Testing
- Mind Body Intervention #1
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Beth Israel Deaconess Medical Center
Lyme Borreliosis, Fibromyalgia
Experiences and Care Pathways Shared on Social Media Regarding 5 Conditions Causing Chronic Pain
Chronic pain is a major symptom shared by several medical conditions. This study focuses on five well-defined chronic diseases : Lyme Borreliosis (LB), Post-Acute COVID-19 Syndrome (PACS or "long COVID"), fibromyalgia…
- Conditions
- Lyme Borreliosis, Fibromyalgia, Rheumatoid Arthritis (RA), Post Acute COVID 19 Syndrome
- Trial name
- NCT07871578
- Where
- France
- Volunteers
- 501 people
- Sponsor
- Central Hospital, Nancy, France
Post-COVID-19 Syndrome
Feasibility of a Well-being Promotion Self-management Intervention in Post-COVID-19 Patients
A training comprised of positive psychological interventions set out to improve mental well-being was developed for post-COVID-19 patients. This study aims to evaluate the feasibility and acceptability of this training.
- Trial name
- NCT06658340
- Testing
- Positivity in Post-COVID
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- University of Twente
Long COVID, COVID-19
Five-year Follow-up After Sars-CoV-2 Infection: Prevalence and Evolution of Post-acute Sequalae of COVID-19 (PASC)
This multicenter, observational, retrospective-prospective study aims to evaluate the prevalence and trajectory of Post-Acute Sequelae of COVID-19 (PASC) approximately 5 years after SARS-CoV-2 infection.
- Conditions
- Long COVID, COVID-19, Post-Acute COVID-19 Syndrome, Post-Acute COVID-19 Infection
- Trial name
- PASC-5Y (NCT07766512)
- Testing
- Post-Acute Sequelae of COVID-19 (PASC) Assessment
- Volunteers
- 900 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
SARS-CoV Infection
Diode Laser 940 nm in Management of Loss of Taste Sensation
The global pandemic has recently emerged by transmission of SARS-CoV2 virus. The virus has had a massive impact on health, wealth and social aspects worldwide.
- Trial name
- NCT04821999
- Testing
- a 940-nm diode laser
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fayoum University
Long COVID-19 Syndrome, Chronic Fatigue Syndrome
A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial
IRB approval date 14-APR-2024 and public at https://plataformabrasil.saude.gov.br/login.jsf since IURB approval Long COVID is a multi-systemic condition comprising often severe and persistent symptoms (longer than 12 weeks) that…
- Trial name
- REVIVE (NCT06128967)
- Testing
- Fluvoxamine Maleate 100 MG, Metformin Extended Release Oral Tablet
- Where
- 6 sites in Brazil
- Volunteers
- 399 people
- Sponsor
- Cardresearch