Clinical trials: Post-Acute Sequelae of COVID-19
Long COVID
Lithium Long COVID Dose-finding Study
This open-label study will assess if lithium dosages of 30-45mg/day are associated with greater symptomatic benefit than dosages of 10-15mg/day previously assessed among 50 patients with long COVID.
- Trial name
- NCT06108297
- Testing
- Lithium
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- State University of New York at Buffalo
Long COVID
Feasibility of an Augmented Two-Day Step Test and Causal Modeling for Post-Exertional Symptom Exacerbation in Post Covid-19 Syndrome
This study aims to evaluate exercise capacity and identify causes of Post-Exertional Symptom Exacerbation (PESE) in individuals with Long COVID.
- Trial name
- REVEAL (NCT06933017)
- Testing
- Portable mask for respiratory gas analysis, Cardio-pulmonary exercise test
- Where
- 2 sites in Belgium
- Volunteers
- 25 people
- Sponsor
- Universitair Ziekenhuis Brussel
Long COVID-19
Long COVID-19 Intervention (COVIDL/MIQoL)
The goal of this clinical trial is to assess the effectiveness of a multicomponent intervention in individuals with Long COVID. The main questions it aims to answer are: Does the intervention increase quality of life, mental…
- Trial name
- COVIDL/MIQoL (NCT06492590)
- Testing
- Multicomponent intervention
- Where
- Spain
- Volunteers
- 74 people
- Sponsor
- Consorci Sanitari de Terrassa
Long COVID
Water-based Activity to Enhance Recovery in Long COVID-19
This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID.
- Trial name
- NCT06142253
- Testing
- WATER+CT, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Long COVID, Post Acute Sequelae of COVID-19
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Background: SARS-CoV-2 is the virus that causes COVID-19. Some people who recover from COVID-19 have long-term symptoms that affect the brain.
- Trial name
- NCT06920628
- Testing
- 11C-PS13
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Reproductive Disorder, Neurodegeneration
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease
The objective of this protocol is to use a case-control paradigm to compare the response to an intravenous administration of kisspeptin in individuals with and without post-covid-19 syndrome.
- Conditions
- Reproductive Disorder, Neurodegeneration, SARS-CoV 2, Long COVID
- Trial name
- NCT07224490
- Testing
- Kisspeptin 112-121
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stephanie B. Seminara, MD
COVID-19, Post-Acute COVID-19
Genetic Risk Factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID Condition
We will perform Whole Exome Sequencing on DNA from saliva. We will include: Children with a history of MIS-C; children with post-COVID condition; and controls in order to identify rare, high impact genetic variants in…
- Conditions
- COVID-19, Post-Acute COVID-19, Post-Acute COVID19 Syndrome, Multi-System Inflammatory Syndrome in Children
- Trial name
- GRIP (NCT05722717)
- Testing
- Saliva collection at home
- Where
- Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Long COVID
Stellate Ganglion Block for Long COVID Symptoms: A Randomized Controlled Trial
This single-center, randomized, controlled, single-blind clinical trial evaluates whether a stellate ganglion block (SGB) using bupivacaine can improve persistent symptoms in adults with long COVID.
- Trial name
- STAR-CO (NCT07374562)
- Testing
- Stellate Ganglion Block (Bupivacaine)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
PASC Post Acute Sequelae of COVID 19, Fatigue
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC).
- Trial name
- NCT07278388
- Testing
- Physical Fatigue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Long COVID, PTLDs
A Prospective Study to Evaluate the Role of T-Cell Dysfunction in Patients Who Present Symptoms Associated With Long COVID, Lyme Disease and Myalic Encephalomyelitis / Chronic Fatigue Syndrome Using the Vira Immune Fluorospot T Cell Assay
This is a longitudinal observational study recruiting individuals that have attended three clinical sites with symptoms associated with a diagnosis of long COVID, PTLDS or ME/CFS.
- Conditions
- Long COVID, PTLDs, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
- Trial name
- NCT06731179
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- ViraxBio Labs
Long COVID, Long Covid19
RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine)
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06305806
- Testing
- Ivabradine, Coordinated Care, Usual Care
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Kanecia Obie Zimmerman
Post-acute COVID-19 Syndrome
Education of Medical Staff to Post Acute Covid susTained sYmptoms
Evaluation of the effectiveness of a training and support intervention for general practitioners treating patients with persistent symptoms after a COVID-19 episode on the patients'quality of life at 3 months.
- Trial name
- EMPATY (NCT06082258)
- Testing
- Training in the management of functional disorders, Reimbursement of 3 long consultations
- Where
- 7 sites in France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, COPD
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
Lung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease.
- Conditions
- Asthma, COPD, Covid19, Long COVID
- Trial name
- MURDOCH (NCT04872309)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Long COVID, Post-acute COVID-19 Syndrome
Home-based Exercise Program in Patients With the Post-COVID-19 Condition
The management of the sequelae of COVID-19 is described as the next great challenge of global public health. Multiple symptoms may compose the clinical picture of these patients (eg, fatigue, dyspnea, cognitive dysfunction…
- Trial name
- NCT05360563
- Testing
- Home-based physical training
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- University of Sao Paulo
Long COVID, Distress Tolerance
Long COVID-19 Intervention Using Digital Health & Technology
The current study seeks to pilot test the iENDURE (Enhancing Distress tolerance to Uplift motivation in Recovery) intervention among 10 participants with Long COVID (Coronavirus Disease) symptoms.
- Trial name
- LIGHT (NCT05616806)
- Testing
- iENDURE
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Post-COVID Condition
Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition
SARS-CoV-2 is the coronavirus responsible for developing the disease known as COVID-19. Once the acute phase of the disease has passed, about 40% of the people who discharged continue to have symptoms, and of these, between 50…
- Trial name
- ARACOV-02 (NCT06063031)
- Testing
- Active
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Long COVID
Cognitive Impairment and Return to Work in Long COVID
This retrospective, single-center observational study investigates the relationship between cognitive performance and return to work in patients with Long COVID.
- Trial name
- REWORK-COV (NCT07881029)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hopitaux de Saint-Maurice
SARS-CoV-2 Acute Respiratory Disease, Myalgic Encephalomyelitis
Does a Technology Enabled Multi-disciplinary Team-based Care Model for the Management of Long COVID and Other Fatiguing Illnesses Improve Clinical Care of Patients and Represent a Sustainable Approach Within a Federally Qualified Health Center?
The primary objective of the present research is to determine the effectiveness of Family Health Center of San Diego's Long COVID and Fatiguing Illness Recovery Program (LC\&FIRP) on clinician- and patient-level outcomes.
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Post-acute Sequelae of SARS-COV-2 Infection
- Trial name
- LC&FIRP (NCT05167227)
- Testing
- Extension for Community Healthcare Outcomes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Family Health Centers of San Diego
Depression, Post-COVID-19 Syndrome
Evaluation of DEPREXIL in Patients With Clinical Depression Through Psychological and Neuroendocrine Assessment
Clinical depression is a mood disorder that affects people of all ages with symptoms such as sadness, anger or frustration, appetite changes, difficulty concentrating and suicidal thoughts.
- Conditions
- Depression, Post-COVID-19 Syndrome, Depression Mild, Depression Moderate
- Trial name
- NCT06496087
- Testing
- DEPREXIL
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Catalysis SL
Long COVID, Long COVID Syndrome
A Study to Examine Anktiva for the Treatment of COVID-19.
This study will examine the safety and effectiveness of Anktiva in treating patients with Long COVID-19 which is defined as persistent symptoms of a COVID-19 infection that remain after the infection is over.
- Conditions
- Long COVID, Long COVID Syndrome, Long Covid 19
- Trial name
- NCT07123727
- Testing
- Anktiva
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.