Clinical trials: Post-Concussion Syndrome, open to volunteers
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms
This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals…
- Trial name
- NCT07246993
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Traumatic Brain Injury, Mild Traumatic Brain Injury
Effect of Graded Aerobic Exercise in Mild Traumatic Brain Injury
There is a paucity of knowledge about mechanisms behind mild traumatic brain injury (mTBI) subgroup's sustained problems, and effective interventions that can alleviate this disabling condition.
- Trial name
- NCT06177509
- Testing
- Graded Aerobic Exercise
- Where
- 2 sites in Norway
- Volunteers
- 72 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Concussion Post Syndrome, Head Trauma Injury
Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients…
- Trial name
- IMPACT (NCT07634393)
- Testing
- Metoclopramide 10mg, Acetaminophen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Montefiore Medical Center
Post-Concussion Syndrome, Headache
Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in…
- Trial name
- NCT04685772
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Concussion, Brain, Brain Injury Traumatic Mild
Concussion Health Improvement Program
More than 1 million U.S. youth sustain a concussion each year, and up to 30% report persistent post-concussive symptoms (PPCS) lasting 1 month or more.
- Trial name
- CHIP (NCT06036147)
- Testing
- Concussion-focused cognitive behavioral therapy, Parent skills training, Care management
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Concussions, Mild Traumatic Brain Injury, Concussion
Mindfulness-Based Intervention for Pediatric Mild Traumatic Brain Injury
Formal MBIs, such as Mindfulness-Based Stress Reduction (MBSR), have been shown to increase resiliency and teach affect regulation.
- Conditions
- Concussions, Mild Traumatic Brain Injury, Concussion, Concussion Mild
- Trial name
- MBI-4-mTBI (NCT07272941)
- Testing
- Mindfulness Based Intervention (MBI)
- Where
- 5 sites in Canada
- Volunteers
- 362 people
- Sponsor
- Children's Hospital of Eastern Ontario
Patients With Persistent Post-concussion Symptoms
Electroencephalography Markers of Brain Stimulation in Post-Concussion Patients
In this randomized, sham-controlled, two-group, parallel, single-session study, the investigators aim to identify EEG biomarkers associated with cerebellar transcranial direct current stimulation (tDCS) in patients with…
- Trial name
- Stim-PPCS (NCT07895797)
- Testing
- tDCS 8 channels
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- University of Liege
Brain Concussion, Mild Traumatic Brain Injury
Get Going After concussIonN Lite
Background: Concussion affects around 25 000 people each year in Denmark. A large research initiative (GAIN 2.0) has been established, and the current study is a part of this initiative. Aims: 1.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Commotio Cerebri
- Trial name
- GAIN Lite (NCT05233475)
- Testing
- Enhanced usual care (EUC), Get Going after concussIoN Lite
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Post-Concussion Syndrome
Rehabilitation in Post Concussion Syndrome
This project evaluates and quantifies the effects of an individually tailored exercise program applied to patients with long-lasting symptoms after concussion, minor traumatic brain injury, so-called Post-Concussion Syndrome…
- Trial name
- REPCon (NCT05785000)
- Testing
- Physical exercise programme as an add-on, Control patients receiving usual care
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Growth Hormone Deficiency, Traumatic Brain Injury
Charactertizing Growth Hormone Deficiency in Traumatic Brain Injury
The goal of this observational study is to characterize the impact of growth hormone deficiency (GHD) on quality of life, symptom burden, and sleep in adults with traumatic brain injury (TBI), and to evaluate whether these…
- Trial name
- NCT07795736
- Testing
- Not applicable (observational study)
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Concussion (Diagnosis), Concussion Post Syndrome
Female Concussion Head Cooling
This research is being done to examine the benefits of a 28 day head cooling intervention on cognition, inflammation of the brain, sleep quality, menstrual symptom interaction, and mood in acutely concussed females.
- Conditions
- Concussion (Diagnosis), Concussion Post Syndrome, Concussion, Mild
- Trial name
- NCT07303933
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Penn State University
Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study
The goal of this study is to examine changes in blood biomarkers following hyperbaric oxygen therapy (HBOT) in military veterans with traumatic brain injury and persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms, PTSD
- Trial name
- NCT07849465
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Summit Hyperbarics and Wellness
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Persistent Post-concussive Symptoms, Post Traumatic Headache
SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function.
This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms.
- Trial name
- SPINEPASS (NCT06882239)
- Testing
- SPINEPASS Physical Therapy, Standard Physical Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Queensland
Persistent Post-concussive Symptoms
Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms
Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity.
- Trial name
- taVNS-PPCS (NCT07017257)
- Testing
- Active taVNS
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- University of Liege
Traumatic Brain Injury, Post-Concussion Syndrome
Cognitive Effects of Hyperbaric Oxygen Therapy (HBOT) After a Traumatic Brain Injury
This is a retrospective, single-center observational study evaluating the cognitive effects of hyperbaric oxygen therapy (HBOT) in adults who sustained a traumatic brain injury (TBI).
- Trial name
- NCT07883668
- Testing
- Hyperbaric Oxygen Therapy - HBOT
- Volunteers
- 1,000 people
- Sponsor
- Assaf-Harofeh Medical Center
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University