Clinical trials: Post-Concussive Symptom
Post Concussive Syndrome
An fMRI Study of Attention and Effort After Concussion
Approximately 1.1 million people a year suffer a mild traumatic brain injury (MTBI), or concussion, in the United States. Although most MTBI patients fully recover, as many as 28% have physical, cognitive, and/or emotional…
- Trial name
- NCT00653029
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Post-Concussive Syndrome, Chronic, Post-Concussion Syndrome
Impact of Photobiomodulation on Objective, Physiological Measures of Brain Function in Individuals With Post-Concussion Syndrome
Photobiomodulation therapy (PBMT) uses light to influence the mitochondria of cells. PBMT of the brain enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as…
- Conditions
- Post-Concussive Syndrome, Chronic, Post-Concussion Syndrome, Mild Traumatic Brain Injury
- Trial name
- NCT05097222
- Testing
- BioFlex Dualport System
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- Dr George Medvedev
Post-Concussion Syndrome, Anxiety Disorders and Symptoms
Breath Control and Mindfulness for Post Concussion Anxiety and Depression: a Feasibility Study
Persistent-post-concussion symptoms (PPCS) is a condition that effects on average one in seven persons following a concussion. Anxiety and depression symptoms are experienced by over one-third of those with PPCS.
- Conditions
- Post-Concussion Syndrome, Anxiety Disorders and Symptoms, Depressive Symptoms
- Trial name
- NCT04708522
- Testing
- Breath Control - Equal Breathing Technique, Guided Mindfulness Exercise, Control
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Concussion Post Syndrome
A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents
The objective of this study is to evaluate the efficacy of magnesium in symptomatic reduction of mild traumatic brain injury in the adolescent population in the acute setting of injury.
- Trial name
- NCT03475693
- Testing
- Magnesium Oxide, Acetaminophen, Zofran ODT 4 MG Disintegrating Oral Tablet
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
Patients With Persistent Post-concussion Symptoms
Electroencephalography Markers of Brain Stimulation in Post-Concussion Patients
In this randomized, sham-controlled, two-group, parallel, single-session study, the investigators aim to identify EEG biomarkers associated with cerebellar transcranial direct current stimulation (tDCS) in patients with…
- Trial name
- Stim-PPCS (NCT07895797)
- Testing
- tDCS 8 channels
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- University of Liege
Physiological Post-Concussion Disorder, Post-Concussion Syndrome
Sub-maximal Exercise Prescription in Adolescents With Physiological Post-concussion Disorder
Although the vast majority of individuals sustaining a sport-related concussion (SRC) will receive medical clearance to return to sport within 7-10 days, approximately 30% of children and adolescents reporting to the emergency…
- Conditions
- Physiological Post-Concussion Disorder, Post-Concussion Syndrome, Traumatic Brain Injury, Rehabilitation
- Trial name
- NCT03367507
- Testing
- Sub-symptom aerobic exercise
- Where
- 2 sites in Canada
- Volunteers
- 136 people
- Sponsor
- Sport Injury Prevention Research Centre
Post Concussion Syndrome
mHealth Technology in the Treatment of Post-concussion Symptoms
Patients with concussion symptoms are asked by their doctors to stretch, exercise, and practice mindfulness daily. Patients can have a hard time sticking to these activities, which can cause patients to feel symptoms for longer…
- Trial name
- PERSIST (NCT05848193)
- Testing
- MyHeadHealth online application, Standard of Care
- Volunteers
- 88 people
- Sponsor
- McMaster University
Brain Concussion, Post-Concussion Syndrome
Investigating Novel Treatments for Concussion: Impact of Compression Vest on Rehabilitation Outcomes
The purpose of this investigation is to determine the effect of a weighted compression vest in addition to usual medical care and exercise rehabilitation on cardiovascular, neurocognitive, balance and anxiety measures in…
- Trial name
- NCT02362347
- Testing
- London Health Sciences Centre - Compression Vest, exercise
- Where
- 2 sites in Canada
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Post-Concussion Syndrome
Post-concussion Syndrome and Chiropractic
This proof-of-concept trial will explore the effects of manual chiropractic adjustments on nervous system function in individuals with post-concussion syndrome.
- Trial name
- PCS (NCT06151184)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Life University
Concussion, Mild, Mild Traumatic Brain Injury
Post-Concussion Aerobic Exercise
This study is looking at the specific role of an exercise prescription on recovery from concussion symptoms in the general population.
- Trial name
- NCT04539509
- Testing
- Exercise Prescription, Treadmill Test, Monitoring
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms
This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals…
- Trial name
- NCT07246993
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Brain Concussion, Post-Concussion Syndrome
Early Intervention Programme for Young Patients (Aged 15 - 30 Years) With Symptoms Following Concussion.
Background: Five - 15 % of patients with concussion continue to experience impairing physical, cognitive and emotional symptoms longer than 3 months post-injury.
- Trial name
- NCT02337101
- Testing
- Enhanced Usual Care (EUC), EUC + Early intervention programme
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Post-Concussion Syndrome, Headache
Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in…
- Trial name
- NCT04685772
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Concussion, Mild
Mindfulness-Based Intervention for Mild Traumatic Brain Injury
Mindfulness is a promising tool which may foster adaptative interpersonal qualities to reduce the risk of persistent post-concussion symptoms.
- Trial name
- MBI-4-mTBI (NCT05105802)
- Testing
- Mindfulness-Based Intervention
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Children's Hospital of Eastern Ontario
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Post-Concussion Syndrome, Sleep Disorder
Improvement in Sleep Symptomatology and Neurocognitive Function Using Photobiomodulation in Post-Concussion Patients
The emphasis on this study is to review the use of PBMT as a potential treatment modality to improve both sleep symptoms and consequent neuropsychological functions affected by sleep disturbances in a cohort of post-mTBI patients…
- Trial name
- NCT05072743
- Testing
- Photobiomodulation Therapy
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michael Zitney
Traumatic Brain Injury
Neurofeedback Technology (GZNT) for Persistent Post-Concussive Symptoms in Soldiers
A new technology called Global Z-Score Neurofeedback Technology (GZNT) has been identified that can overcome an existing barrier to the use of neurofeedback as a treatment technique in a military setting.
- Trial name
- GZNT (NCT02509689)
- Testing
- Global Z-Score Neurofeedback Training
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The Defense and Veterans Brain Injury Center
Transcranial Magnetic Stimulation, Magnetic Resonance Imaging
Brain Stimulation for Concussion
The goal of this clinical trial is to test a new type of magnetic brain stimulation in patients with persistent post-concussive symptoms.
- Conditions
- Transcranial Magnetic Stimulation, Magnetic Resonance Imaging, Neuropsychological Tests, Traumatic Brain Injury
- Trial name
- NCT05889117
- Testing
- Intermittent theta-burst treatment (iTBS) using MagPro Transcranial Magnetic Stimulator (manufacturer: Magventure)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Mind Research Network
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms
Persistent post-concussive symptoms (PPCS) are a source of significant burden among a subset of patients with concussion with prevalence rates previously reported between 11 - 82% based on timing of assessment, diagnostic…
- Trial name
- HOINPCS (NCT05173818)
- Testing
- Hyperbaric oxygen at 1.5 ATA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Essentia Health
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University