Clinical trials: Post-Operative Condition
Postoperative Complications, Neuromuscular Blockade
An Observational Study to Analyze the Prescription Pattern of Sugammadex and Its Effectiveness and Safety
The purpose of this observational study is to evaluate patients who are planning to administer sugammadex after rocuronium or vecuronium is used. The main questions it aims to answer are: 1. Prescription pattern of sugammadex 2.
- Conditions
- Postoperative Complications, Neuromuscular Blockade, Anesthesia
- Trial name
- SECURE (NCT05788718)
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 6,458 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Post-Amputation Pain, Phantom Limb Pain
Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
The purpose of this study is to determine if electrical stimulation (small levels of electricity) can safely and effectively reduce post-amputation pain. This study involves a device called the SPRINT System.
- Conditions
- Post-Amputation Pain, Phantom Limb Pain, Residual Limb Pain
- Trial name
- NCT01996254
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- SPR Therapeutics, Inc.
Postoperative Ileus
A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy
This study is being conducted to determine whether alvimopan can accelerate recovery of gastrointestinal function following radical cystectomy when compared with a placebo.
- Trial name
- NCT00708201
- Testing
- Alvimopan
- Where
- 20 sites in United States
- Volunteers
- 280 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pain
Fixed-dose Combination of Oxycodone [OXIcodona] + IbuproFEN in Pain Relief After Third Molar Extraction
A clinical, multicenter, randomized, parallel-group, double-blind, double-dummy, comparative study of non-inferiority. ⚠️Study will only be conducted in research centers in Brazil (please do not send e-mail if your center is…
- Trial name
- OXIFEN (NCT05081102)
- Testing
- FDC of oxycodone 5 mg/ibuprofen 400 mg, Tylex
- Where
- Brazil
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Lymphedema, Lymphedema, Breast Cancer
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery
To evaluate the Dayspring Active Wearable Compression Technology in enhancing lymph movement and its safety and effectiveness after lymphatic surgery
- Conditions
- Lymphedema, Lymphedema, Breast Cancer, Lymphedema Arm
- Trial name
- TIGRIS (NCT04888975)
- Testing
- Dayspring Active Wearable Compression System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Koya Medical, Inc.
Post Surgical Ocular Inflammation and Pain
Safety and Efficacy of KPI-121 in Subjects With Postsurgical Inflammation and Pain
The primary objective of the study is to investigate the efficacy and safety of KPI-121 1.0% ophthalmic suspension compared to placebo in subjects who have undergone cataract surgery.
- Trial name
- NCT02793817
- Testing
- KPI-121 1% Ophthalmic Suspension dosed BID, Vehicle of KPI-121 Ophthalmic Suspension dosed BID
- Where
- 35 sites in United States
- Volunteers
- 520 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Cataract
Difluprednate vs. a Prednisolone Acetate - Phenylephrine on Post-operative Inflammation Following Cataract Surgery.
This controlled, randomized, double blind, multicenter study will be carried out to demonstrate that the topical ophthalmic nanoemulsion of difluprednate 0.05% (Tolf®, Poen Laboratories), has a high anti-inflammatory efficacy…
- Trial name
- NCT04631315
- Testing
- Difluprednate Ophthalmic Emulsion 0.05%, Prednisolone Acetate 1% Phenylephrine hydrochloride 0,12% ophthalmic solution
- Where
- Argentina
- Volunteers
- 255 people
- Sponsor
- Laboratorios Poen
Leg Ulcers Venous, Dehiscence, Surgical Wound
Blu Light for Ulcers Reduction
Multi-center study on the effectiveness of treatment with a blue light medical device (EmoLED) in the reduction of ulcer surface in 10 weeks.
- Trial name
- BLUR (NCT04018924)
- Testing
- Illumination with blue light (400-430nm) for 60 seconds with a power density of 120mW/sqcm (EmoLED device)
- Where
- 7 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Emoled
Colorectal Cancer
Application of Polygenic Methylation Markers in Postoperative Recurrence Monitoring of Colorectal Cancer
This study dynamically monitored the prognosis of stage I-IV colorectal cancer patients who could receive radical surgical resection by detecting the levels of polygene methylation in plasma samples from patients with colorectal…
- Trial name
- NCT05444491
- Where
- 7 sites in China
- Volunteers
- 800 people
- Sponsor
- Singlera Genomics Inc.
Post-operative Pain
HSK16149 for Perioperative Analgesia in Orthopedic Surgery
This study will compare the effect and safety of HSK16149 with placebo on perioperative analgesia in orthopedic surgery, and explore the dosage of HSK16149 capsules for orthopedic analgesia during perioperative period.
- Trial name
- NCT06007066
- Testing
- HSK16149 capsule
- Where
- 21 sites in China
- Volunteers
- 235 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Chronic Pain
Algovita Post-Market Clinical Study: Spinal Cord Stimulation to Treat Chronic Pain
The purpose of this study is to obtain real-world clinical outcome data for the Algovita Spinal Cord Stimulation system when used, on-label, according to the applicable directions for use.
- Trial name
- NCT02373540
- Testing
- Algovita Spinal Cord Stimulation system
- Where
- 18 sites in United States, Germany
- Volunteers
- 91 people
- Sponsor
- Nuvectra
Non-small Cell Lung Cancer
Huaier Granule for Prevention of Recurrence and Metastasis of Stage II and III Non-small Cell Lung Cancer (NSCLC)
This study including two parts，one part is a randomized clinical trial design，another part is a registration study.
- Trial name
- NCT03198117
- Testing
- Huaier Granule
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Qidong Gaitianli Medicines Co., Ltd
Corneal Endothelial Cell Loss
Second Comparative Study of Specular Microscopes for Endothelial and Corneal Cell Measurements
The primary objective of this clinical study is to collect additional clinical data to support an FDA 510(k) submission for the Topcon Specular Microscope SP-1P.
- Trial name
- NCT02427256
- Testing
- Topcon Specular Microscope SP-1P, Konan Specular Microscope CELLCHEK XL
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Topcon Medical Systems, Inc.
Kidney Transplantation
A Study to Evaluate the Effect of ASP8597 in Adult Kidney Transplant Patients
The purpose of this study is to evaluate the efficacy, safety and tolerability of a single intravenous dose of ASP8597 in kidney transplant recipients.
- Trial name
- NCT01442337
- Testing
- ASP8597
- Where
- 19 sites in United States
- Volunteers
- 21 people
- Sponsor
- Astellas Pharma Inc
Cataract
Intra-Operative Metrics With CENTURION® and INFINITI® Vision Systems
The purpose of this study is to evaluate intra-operative phacoemulsification machine metrics after phacoemulsification with the CENTURION® vision system configuration compared with the INFINITI® vision system configuration.
- Trial name
- NCT01848288
- Testing
- CENTURION® Vision System (CVS), INFINITI® Vision System (IVS)
- Volunteers
- 112 people
- Sponsor
- Alcon Research
Ankle Rheumatoid Arthritis, Arthritis of Ankle
Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only
The objectives of this study are to evaluate the performance and safety of the Vantage Total Ankle System. This study will follow subjects for a period of up to 10 years post-surgery.
- Conditions
- Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
- Trial name
- NCT05619588
- Where
- 2 sites in United States
- Volunteers
- 370 people
- Sponsor
- Exactech
Hypertension
Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-2)
The purpose of this study is to establish the efficacy of of clevidipine versus placebo in treating postoperative hypertension. Approximately 100 patients with postoperative hypertension undergoing coronary artery bypass grafting…
- Trial name
- ESCAPE-2 (NCT00093262)
- Testing
- clevidipine
- Where
- 15 sites in United States
- Volunteers
- 206 people
- Sponsor
- The Medicines Company
Triple Negative Breast Cancer
Phase I/II, Evaluate the Safety and Efficacy of BLEX 404 With Docetaxel in Patients With Advanced/Metastatic Triple Negative Breast Cancer.
The primary purpose of this study is to determine the safety and recommended dose level (RDL) of BLEX 404 Oral Liquid combined with Docetaxel monotherapy in a 21-day schedule.
- Trial name
- NCT02802423
- Testing
- BLEX 404 Oral Liquid
- Volunteers
- 44 people
- Sponsor
- BioLite, Inc.
Scarring
Amniotic Membrane in Decompressive Craniectomy to Reduce Scarring
The purpose of this study is to evaluate the effectiveness of dHACM in reducing scar tissue formation in craniectomy patients as well as facilitating reoperation and repair.
- Trial name
- NCT02033824
- Testing
- dHACM, Craniectomy
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- MiMedx Group, Inc.
Short Bowel Syndrome
Open-label Extension Trial to Evaluate the Long-term Safety of Apraglutide in Short Bowel Syndrome.
The primary objective of the trial is to assess long-term safety and tolerability of apraglutide in subjects with SBS-IF.
- Trial name
- STARS extend (NCT05018286)
- Testing
- Apraglutide
- Where
- 66 sites in United States, Argentina and 16 more
- Volunteers
- 158 people
- Sponsor
- VectivBio AG