Clinical trials: Post-Operative Condition
Total Knee Arthroplasty, Ischemic Preconditioning
Ischemic Preconditioning in Total Knee Arthroplasty
The application of a tourniquet for 5 minutes and subsequent reperfusion before actual inflation of the tourniquet for total knee arthroplasty (ischemic preconditioning) decreases the level of local inflammation and therefore…
- Conditions
- Total Knee Arthroplasty, Ischemic Preconditioning, Postoperative Pain
- Trial name
- NCT01333969
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Dry Eye
Efficacy, Tolerability, and Comfort of 0.3% Hypromellose Eyedrops in Patients Undergoing LASIK Surgery
This study is designed to assess the tolerability and comfort of peri-operative 0.3% hypromellose eye drops in LASIK surgery patients and to assess whether pre-operative 0.3% hypromellose eye drops add to post-operative comfort…
- Trial name
- NCT00909324
- Testing
- Pre-LASIK 0.3% hypromellose, Post-LASIK 0.3% hypromellose
- Where
- India
- Volunteers
- 170 people
- Sponsor
- Novartis Pharmaceuticals
ACL Injury, Post Operative Pain
iPACK for Post-op Pain Following ACL Reconstruction
This study will consist of patients 12 years and older undergoing ACL reconstruction using a quadriceps or bone-patella tendon bone (BTB) graft.
- Trial name
- NCT05498870
- Testing
- Adductor Canal Block (ACB) Only, Adductor Canal Block (ACB) + iPACK Block
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Medical University of South Carolina
Post Operative Pain
Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)
Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied.
- Trial name
- NCT00385541
- Testing
- Morphine PCA, Hydromorphone PCA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Postoperative Pain
Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
Some patients have respiratory depression (decreased breaths per minute) after surgery. Acetaminophen, an FDA approved pain medication, may prevent this problem.
- Trial name
- NCT02156154
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Incisional Hernia
Xen Matrix™ AB Surgical Graft in Ventral or Incisional Midline Hernias
This study aims to prospectively explore the use of XenMatrix™ AB Surgical Graft for ventral or incisional midline hernia repair in patients across all wound classes ("All Comers") through 24 months post repair.
- Trial name
- NCT02691962
- Testing
- Xen Matrix AB
- Where
- 11 sites in United States
- Volunteers
- 75 people
- Sponsor
- C. R. Bard
Pancreatic Cancer
Gemcitabine and Erlotinib Before and After Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery
PURPOSE: This phase II trial is studying how well gemcitabine and erlotinib work when given before and after surgery in treating patients with pancreatic cancer that can be removed by surgery.
- Trial name
- NCT00733746
- Testing
- erlotinib hydrochloride, gemcitabine hydrochloride, therapeutic conventional surgery
- Where
- 24 sites in United States, Canada
- Volunteers
- 123 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Postoperative Pain, Postoperative Nausea
Postoperative Pain Control Following Hysteroscopy
Intraoperative lidocaine infusion is a frequently preferred method in surgical procedures due to its reducing the need for opioids, providing better postoperative pain control, reducing postoperative nausea and vomiting and…
- Conditions
- Postoperative Pain, Postoperative Nausea, Analgesia
- Trial name
- NCT06423456
- Testing
- Lidocaine IV, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Colon Adenocarcinoma, Stage IIA Colon Cancer AJCC v8
Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery
This phase II/III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works in predicting treatment for patients with stage IIA colon cancer after surgery.
- Trial name
- NCT04068103
- Testing
- Capecitabine, Fluorouracil, Leucovorin
- Where
- 957 sites in United States, Canada and 1 more
- Volunteers
- 635 people
- Sponsor
- NRG Oncology
Pain, Postoperative, Anesthesia
Transversus Abdominal Plane Block at Total Laparoscopic Hysterectomy: Effect on Quality of Recovery
The Transversus Abdominal Plane (TAP) block has been used with good success to decrease postoperative pain following laparatomy.
- Trial name
- TAP (NCT01479270)
- Testing
- TAP Block
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Non-small Cell Lung Cancer
Phase II of Neoadjuvant and Adjuvant Capmatinib in NSCLC
This study was planned to determine if neoadjuvant capmatinib could improve the major pathological response (MPR) in patients with Stage IB-IIIA, N2 and selected IIIB (T3N2 or T4N2) lung cancers with Mesenchymal Epithelial…
- Trial name
- Geometry-N (NCT04926831)
- Testing
- capmatinib
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Postsurgical Pain
Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)
In the pilot (Part A) of this study, multiple doses of CA-008 (vocacapsaicin) were evaluated for safety, tolerability, and PK. Doses were then selected for the expanded part (Part B) of the study, where CA-008 was compared to…
- Trial name
- NCT04203537
- Testing
- CA-008
- Where
- 4 sites in United States
- Volunteers
- 193 people
- Sponsor
- Concentric Analgesics
Thoracotomy, Pain, Postoperative
Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy
Gabapentin is a nerve medication that treats pain. The specific aim of the study is to compare the difference in the postoperative use of no gabapentin, 300 mg gabapentin 3x daily, or 300 mg gabapentin once at night.
- Trial name
- NCT05172570
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Dumping Syndrome
Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome
multi-center, phase II study evaluating efficacy, safety and pharmacokinetics of pasireotide in patients with dumping syndrome
- Trial name
- NCT01637272
- Testing
- SOM230
- Where
- 17 sites in United States, Belgium and 3 more
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
A Study of Rucaparib Administered With Radiation in Patients With Triple Negative Breast Cancer With an Incomplete Response Following Chemotherapy
The purpose of this study is to test the safety of a study drug called Rucaparib, administered in combination with the type of radiation therapy that is usually given to women with your form of breast cancer.
- Trial name
- NCT03542175
- Testing
- Rucaparib, Radiotherapy
- Where
- 8 sites in United States
- Volunteers
- 31 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Pain
Magnesium vs Placebo for Tonsillectomy
This study is a double-blind randomized controlled trial using intravenous magnesium versus placebo to determine if systemic magnesium can decrease postoperative pain in pediatric patients undergoing tonsillectomy.
- Trial name
- NCT02218424
- Testing
- Magnesium, Normal saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pain, Postoperative
Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain
The objective of the study is to evaluate the efficacy and safety of a single oral dose of two dose combinations of naproxen sodium and diphenhydramine (DPH) to demonstrate that naproxen sodium/DPH combination provides added…
- Trial name
- Morpheus II (NCT01280591)
- Testing
- Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111), Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111), Naproxen sodium 440 mg (BAYH6689)
- Where
- 2 sites in United States
- Volunteers
- 712 people
- Sponsor
- Bayer
Neuralgia
P4 (Pregabalin for Peripheral Posttraumatic Pain)
To evaluate the efficacy of pregabalin compared to placebo in the treatment of posttraumatic peripheral neuropathic pain
- Trial name
- P4 (NCT00292188)
- Testing
- pregabalin
- Where
- 44 sites in Belgium, Canada and 9 more
- Volunteers
- 255 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Postoperative Pain, Breast Cancer
Administration of Ketamine to Prevent the Post-operative Pain
The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse…
- Trial name
- KETAMINE (NCT00210210)
- Testing
- Ketamine, Saline solution
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Institut Bergonié
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.