Clinical trials: Post-Operative Condition
Perforated Appendicitis
The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis
The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT02881996
- Testing
- IV tylenol, No IV tylenol, Ketorolac
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Mercy Hospital Kansas City
Short Bowel Syndrome
Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 Study
The purpose of this study is to evaluate the safety and efficacy of teduglutide treatment of children with short bowel syndrome (SBS) who completed the TED-C13-003 study over a long-term period.
- Trial name
- NCT02949362
- Testing
- Teduglutide, SOC
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 29 people
- Sponsor
- Shire
Renal Calculus, Kidney Stones
Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy
The purpose of this study is to determine whether continuous intravenous ketorolac infusion reduces pain in patients who are having percutaneous nephrolithotomy for kidney stone disease.
- Trial name
- NCT00765128
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Short Bowel Syndrome
Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Teduglutide in Japanese Subjects With PN-dependent Short Bowel Syndrome (SBS)
The purpose of this study is to evaluate the safety and efficacy of an investigational treatment (teduglutide) in Japanese patients with PN-dependent SBS.
- Trial name
- NCT02340819
- Testing
- Teduglutide
- Where
- 5 sites in Japan
- Volunteers
- 11 people
- Sponsor
- Shire
Obesity, Surgical Site Infections
Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery
The investigators aim to show that single use negative pressure dressings can decrease the rate of wound complications in obese women (BMI > 40 kg/m2) undergoing cesarean delivery at a tertiary medical center by randomizing women…
- Conditions
- Obesity, Surgical Site Infections, Wound Complications, Complications; Cesarean Section
- Trial name
- NCT02799667
- Testing
- Standard Dressing, Negative Pressure Wound Therapy Dressing
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Pain, Postoperative
Evaluation of Preoperative N1539 in Total Knee Arthroplasty
The primary objective of this study is to assess the effect of preoperative administration of N1539 on opioid consumption in subjects undergoing open unilateral total knee arthroplasty compared to placebo.
- Trial name
- NCT03434275
- Testing
- N1539
- Where
- 6 sites in United States
- Volunteers
- 194 people
- Sponsor
- Baudax Bio
Phantom Limb
Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Individuals with upper-limb amputation usually have intact nerves within the residual limb, and studies have demonstrated that electrical stimulation of those nerves can produce sensations that appear to emanate from the…
- Trial name
- PhantomLimb (NCT02684201)
- Testing
- Boston Scientific Stimulator Lead
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lee Fisher, PhD
Postoperative Pain
Intrathecal Morphine for Cesarean Delivery
This is a randomized double blinded non-inferiority study comparing the duration of pain relief when patients receive one of three doses of spinal morphine.
- Trial name
- NCT05069012
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Beth Israel Deaconess Medical Center
Total Knee Arthroplasty, Knee Pain
Optimizing Local Anesthetic Concentration for Continuous Femoral Nerve Blocks
This is a randomized, observer-masked, controlled study. Subjects will be patients undergoing bilateral total knee arthroplasty (TKA).
- Trial name
- NCT00923598
- Testing
- 0.1% and 0.4% perineural ropivicaine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, San Diego
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Postoperative Pain
Magnesium Sulfate for Analgesia in Pediatric Transplant
To use magnesium sulfate as adjuvant analgesia by implementing a treatment protocol in order to determine whether can benefit pediatric pain in post-operative transplanted patients and decrease overall opioid consumption.
- Trial name
- NCT04812028
- Testing
- Magnesium sulfate
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Minnesota
Postoperative Wound Infection
Study of the Efficacy of Plain Soap and Water Versus Alcohol-based Rubs for Surgical Hand Preparation
Surgical site infections (SSI) constitute a significant health-economic and clinical challenge. The investigators conducted a cluster-randomized, cross-over study to compare the efficacy of plain soap and water (PSW), used…
- Trial name
- NCT00987402
- Testing
- Plain soap and water (PSW), Alcohol-based hand rub (ABHR)
- Where
- Kenya
- Volunteers
- 3,317 people
- Sponsor
- University Hospital, Geneva
Post-Operative Nausea and Vomiting
A Study to Examine the Safety and Tolerability of MK0517 for the Prevention of Post-Operative Nausea and Vomiting (0517-015)
A new intravenous medication is being tested for the prevention of the nausea and vomiting that occurs after surgery. This new medication is being compared to another intravenous medication that is already available to patients…
- Trial name
- NCT00231777
- Testing
- Comparator: MK0517, Comparator: ondansetron
- Volunteers
- 216 people
- Sponsor
- Merck Sharp & Dohme LLC
Kidney Calculi
Stone Access and Removal (STAR) Study
The purpose of the study is to assess procedural completion, the post-operative stone clearance and the safety profile following robotic mini-Percutaneous Nephrolithotomy (PCNL) performed with the MONARCH Platform, Urology.
- Trial name
- STAR (NCT06330701)
- Testing
- Robotic-assisted mini-PCNL
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Auris Health, Inc.
Pain, Postoperative
Comparison of Local Anesthetic Infusion Pump Versus Depofoam Bupivacaine for Pain Management
Effective post surgical pain control in patients undergoing unilateral deep inferior epigastric perforator (DIEP) free flap reconstruction.
- Trial name
- NCT04284930
- Testing
- Depobupivacaine, OnQ pump, 0.25% Bupivacaine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease, Pain, Postoperative
Parasternal Nerve Block in Cardiac Patients
Exparel is a new local analgesic (numbing medication) that is intended to be longer acting than currently available local analgesics.
- Trial name
- NCT01826851
- Testing
- Exparel
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Peter A Knight
Femoral Fractures, Pain, Postoperative
Efficacy Study of Femoral Nerve Block in Children With a Femur Fracture
The purpose of this study is to examine the efficacy of the use of Marcaine in femoral nerve blocks and hematoma blocks for post operative pain relief for femoral shaft fractures in a pediatric population.
- Trial name
- NCT01294098
- Testing
- Marcaine
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Pain, Postoperative, Pain, Acute
Nurse Initiated Acupressure for Pain Management
The purpose of pilot study is to test the feasibility of nurse initiated post-operative bilateral auricular acupressure as an adjunct to medication for post-operative pain management.
- Trial name
- NCT04044716
- Testing
- Auricular acupressure, Standard of care pain management
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Wake Forest University Health Sciences
Post Cesarean Pain
Dosing of Ketorolac Impacts Post-cesarean paiN manaGemenet (KING)
This is a randomized controlled single blinded trial to compare the morphine milligram equivalents (MME) use in the first 24 hours postoperatively after cesarean section in patients receiving a single dose of 30 mg intravenous…
- Trial name
- KING (NCT05248984)
- Testing
- Ketorolac 30 Mg, Ketorolac 60 Mg
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Ohio State University
Postoperative Nausea and Vomiting
Effect of Intraoperative Anesthetic Management on Postoperative Nausea and Vomiting in Bariatric Surgery
Morbidly obese patients are at high risk for Postoperative Nausea and Vomiting (PONV) after surgery and general anesthesia. The results of our observational study indicate that 42.7% of patients require medication to treat PONV…
- Trial name
- NCT01449708
- Testing
- TIVA NoNarc
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Coastal Anesthesiology Consultants
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