Clinical trials: Post-Operative Condition
Postoperative Hypoparathyroidism, Thyroid Disease
Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy
This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)'…
- Conditions
- Postoperative Hypoparathyroidism, Thyroid Disease, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT05579782
- Testing
- NIRAF Detection Technology
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Total Hip Arthroplasty, Postoperative Pain
A Comparison of Postoperative Analgesic Nerve Block Ropivacaine Concentrations
Peripheral nerve blocks are the standard of care for pain management after hip replacement surgery at UPMC Shadyside. This prospective, randomized study is intended to assess the effect of 0.1 versus 0.2% ropivacaine in lumbar…
- Trial name
- NCT01556724
- Testing
- 0.1% or 0.2% ropivacaine nerve blocks
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sylvia Wilson
Phantom Limb Pain, Residual Limb Pain
Pulsed Electromagnetic Fields for Post-Amputation Pain
Pulsed electromagnetic field therapy is a possible method of pain control involving the application of electromagnetic energy (also termed nonthermal, pulsed, shortwave radiofrequency therapy).
- Trial name
- NCT05392803
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Diego
Phantom Limb Pain
Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
When a limb is traumatically severed, pain perceived in the part of the body that no longer exists often develops. This is called "phantom limb" pain, and is different from "stump" pain, which is pain within the part of the limb…
- Trial name
- DoD-PLP-Tx (NCT01824082)
- Testing
- Perineural infusion [continuous peripheral nerve block(s)]
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Diego
Pain
Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength
All patients over the age of 16 undergoing primary or revision anterior cruciate ligament reconstruction with the use of bone-patellar-bone autograft are eligible for the study.
- Trial name
- NCT03033589
- Testing
- Marcaine 0.25 % Injectable Solution
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Pain, Postoperative
Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain
This study will evaluate the safety and tolerability based on the incidence of adverse experiences of buprenorphine sublingual spray (0.5 milligrams [mg] three times daily [TID]) compared with standard post-operative narcotic…
- Trial name
- NCT03254459
- Testing
- Buprenorphine Sublingual Spray, Morphine, Oxycodone Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- INSYS Therapeutics Inc
Postoperative Delirium, PD
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
This is a pilot study to evaluate the effect of dexmedetomidine in the prevention of delirium in non-cardiac surgical patients. The preliminary data regarding the effect of dexmedetomidine on delirium comes from a study underway…
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00455143
- Testing
- Precedex (Dexmedetomidine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Morbid Obesity, Postoperative Pain
Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery
This prospective randomized controlled trial aims to compare the clinical effectiveness and safety of opioid-free anesthesia (OFA) versus traditional opioid-based anesthesia (OBA) in adult patients undergoing laparoscopic…
- Conditions
- Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia, Bariatric Surgery
- Trial name
- NCT07337135
- Testing
- Opioid-Based Anesthesia (Remifentanil-Based Protocol), Opioid-Free Anesthesia (Dexmedetomidine-Ketamine-Lidocaine Protocol)
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Hospital dos Lusíadas
Acute Pain, Postoperative
Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain
The purpose of this study is to compare intravenous (IV) and oral acetaminophen for the treatment of acute moderate to severe pain in combination with standard patient-controlled analgesia (PCA) in adult subjects following total…
- Trial name
- NCT02746263
- Testing
- IV acetaminophen, Oral acetaminophen, Morphine
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mallinckrodt
Short Bowel Syndrome
A Study in Japanese Children With Short Bowel Syndrome Who Completed SHP633-302
The purpose of this clinical study is to evaluate the long-term safety and tolerability of teduglutide treatment in Japanese pediatric participants with short bowel syndrome (SBS) who completed Study SHP633-302 (NCT02980666).
- Trial name
- NCT03268811
- Testing
- Teduglutide
- Where
- 6 sites in Japan
- Volunteers
- 9 people
- Sponsor
- Shire
Acute Pain
Oral Treatment for Orthopaedic Post-operative Pain With Dexketoprofen Trometamol and Tramadol Hydrochloride
This study aims to evaluate the analgesic efficacy of single and repeated doses of fixed combination of dexketoprofen trometamol (DKP) and tramadol hydrochloride (TRAM) in comparison to the single agents (and placebo for the…
- Trial name
- DAVID-art (NCT01902134)
- Testing
- Tramadol-single dose, Dexketoprofen-single dose, Dexketoprofen/Tramadol-single dose
- Where
- 37 sites in Czechia, Germany and 8 more
- Volunteers
- 641 people
- Sponsor
- Menarini Group
Interstitial Cystitis
Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis
The purpose of this study is to assess the effects of dexmedetomidine while patients undergo treatment for Interstitial Cystitis (IC).
- Trial name
- NCT01195116
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Rochester
Postoperative Pain
Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty
The primary objectives of Part 1 are to (1) evaluate three dose levels of liposome bupivacaine versus placebo with respect to the magnitude and duration of the analgesic effect achieved following single dose injection femoral…
- Trial name
- NCT01683071
- Testing
- EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
- Where
- 30 sites in United States
- Volunteers
- 297 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Retinal Detachment
Using Triamcinolone Acetonide to Reduce Pain After Scleral Buckle Surgery
PURPOSE: Scleral buckle surgery is a widely used ophthalmic surgery for the correction of rhegmatogenous retinal detachment. Studies suggest that eye pain is a common and underestimated occurrence after scleral buckle surgery…
- Trial name
- NCT04701593
- Testing
- Triamcinolone Acetonide 40mg/mL
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Polytechnic Institute and State University
Delirium, Cognitive Impairment
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
The purpose of this study is to investigate the effectiveness of a preventative low-dose of Haloperidol to prevent delirium in patients undergoing a esophagectomy, pneumonectomy or thoracotomy.
- Conditions
- Delirium, Cognitive Impairment, Post-traumatic Stress Disorder, Depression
- Trial name
- PE-POD (NCT02213900)
- Testing
- Haloperidol
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Indiana University
Hernia
Repair of Infected or Contaminated Hernias
This is a prospective, multicenter, interventional, observational, open label, single arm, longitudinal evaluation of ventral incisional hernia repair using LTM in contaminated or infected sites.
- Trial name
- RICH (NCT00617357)
- Testing
- LTM (Strattice Reconstructive Tissue Matrix)
- Where
- 15 sites in United States
- Volunteers
- 83 people
- Sponsor
- LifeCell
Postcholecystectomy Syndrome
Effect of Rowachol on Prevention of Postcholecystectomy Syndrome
Postcholecystectomy syndrome (PCS) includes a heterogeneous group of diseases, usually manifested by the presence of abdominal symptoms following gallbladder removal.
- Trial name
- NCT01765465
- Testing
- Rowachol
- Where
- 2 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- DongGuk University
Total Parenteral Nutrition-induced Cholestasis, Cholestasis
Compassionate Use of Omegaven in Children
This is a single-assignment study to evaluate whether Omegaven (IV fish oil) is effective at treating liver disease in children on long-term IV nutrition.
- Conditions
- Total Parenteral Nutrition-induced Cholestasis, Cholestasis, Short Bowel Syndrome, Gastroschisis
- Trial name
- NCT02370251
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Oklahoma
Hysterectomy, Pain, Postoperative
B&O for TLH Post-operative Pain and Nausea
A prospective, single-center, double-blind, randomized, placebo-controlled trial to assess the impact of immediate post-operative placement of a Belladonna and Opium (B\&O) rectal suppository on postoperative pain and nausea…
- Trial name
- NCT03657407
- Testing
- Belladonna Opium, Glycerin Suppository
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Anna Reinert
Postoperative Pain
Intravenous Acetaminophen in Craniotomy
The purpose of this study is to assess the use of intravenous Acetaminophen (OFIRMEV) as an effective adjunct therapeutic agent in patients undergoing craniotomy.
- Trial name
- NCT01598701
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
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