Clinical trials: Post-Operative Nausea and Vomiting (PONV)
Postoperative Nausea and Vomiting
Phase II Dose-ranging Study of APD421 in PONV
To assess the efficacy and safety of different doses of APD421 in the prevention of post-operative nausea and vomiting (PONV) in adult patients at moderate to high-risk of PONV.
- Trial name
- NCT01510704
- Testing
- APD421
- Where
- 13 sites in United States, France and 1 more
- Volunteers
- 215 people
- Sponsor
- Acacia Pharma Ltd
Nausea and Vomiting, Postoperative
Post Operative Nausea and Vomiting (PONV) Rescue Outcomes After Amisulpride Treatment
PROMPT (PONV Rescue Outcomes after AMisulPride Treatment) is an observational Phase IV study designed to evaluate real-world evidence in relation to the care continuum of Post Operative Nausea and Vomiting (PONV), as well as the…
- Trial name
- PROMPT (NCT04954365)
- Testing
- Rescue Post-Operative Nausea and Vomiting (PONV) treatment according to the standard of care (SOC), Amisulpride
- Sponsor
- Acacia Pharma Ltd
Post-Operative Nausea and Vomiting
A Study of Kytril (Granisetron) in the Prevention of Post-Operative Nausea and Vomiting (PONV) in Pediatric Subjects Undergoing Tonsillectomy or Adenotonsillectomy
This 2 arm study will evaluate the efficacy and safety of a single intravenous injection of Kytril in preventing postoperative nausea and vomiting (PONV) in children.
- Trial name
- NCT00231478
- Testing
- granisetron
- Where
- 11 sites in United States
- Volunteers
- 171 people
- Sponsor
- Hoffmann-La Roche
Nausea and Vomiting, Postoperative, Nausea With Vomiting Chemotherapy-Induced
Crossover Study Comparing Ondansetron Orally Dissolving Film Strip (ODFS) With Zofran Orally Disintegrating Tablets
This was an open-label, balanced, two-treatment, two-period, randomized sequence crossover bioequivalence study with a 7-day washout between periods. Each treatment was administered after an overnight (10 hours) fast.
- Trial name
- 01905/08-09 (NCT01217190)
- Testing
- Ondansetron (ODFS), Zofran (ODT)
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- MonoSol Rx
Postoperative Nausea and Vomiting
A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)
This two part study will determine the appropriate dosing regimen of aprepitant for the prevention of postoperative nausea and vomiting (PONV) in pediatric participants 6 months to 17 years of age, by assessing pharmacokinetic…
- Trial name
- NCT00819039
- Testing
- Aprepitant, Ondansetron
- Where
- 6 sites in United States, Brazil and 3 more
- Volunteers
- 98 people
- Sponsor
- Merck Sharp & Dohme LLC
Post-Operative Nausea and Vomiting (PONV)
Single Dose Safety Study for Compound to Treat Post-Operative Nausea and Vomiting (PONV)
The purpose of this study is to describe the safety and tolerability and pharmacokinetics of a single intravenous administration of the new, Sulfobutyl Ether-7-Beta-Cyclodextrin (Captisol™) based, formulation in Healthy Adult…
- Trial name
- NCT01290133
- Testing
- GW597599
- Where
- Australia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Accenture
Nausea and Vomiting, Postoperative
Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In Women
This study is being conducted to see if adding GW679769 (casopitant) to ZOFRAN will significantly decrease the number of patients who experience nausea and vomiting after surgery.
- Trial name
- NCT00326248
- Testing
- GW679769 (casopitant)
- Where
- 58 sites in United States, Canada and 9 more
- Volunteers
- 482 people
- Sponsor
- GlaxoSmithKline
Postoperative Nausea and Vomiting
Phase I PK and Safety Study of Ondansetron Inhalation Powder
The goal of this clinical trial is to learn if LPI-1503 (Ondansetron Inhalation Powder) can deliver ondansetron into blood through inhalation. It will also learn about the safety of LPI-1503.
- Trial name
- NCT07498751
- Testing
- LPI-1503, IV Ondansetron, Oral Ondansetron
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Luxena Pharmaceuticals, Inc.
PONV
European Phase III Study of APD421 in PONV
A comparison of the efficacy of APD421 and placebo in the prevention of PONV in patients at moderate-to-high risk of PONV.
- Trial name
- NCT01991821
- Testing
- APD421
- Where
- 2 sites in France, Germany
- Volunteers
- 368 people
- Sponsor
- Acacia Pharma Ltd
PONV
Phase IIIb Study of APD421 in Combination as PONV Prophylaxis
A comparison of the efficacy of APD421 and placebo when combined with a standard anti-emetic in the prevention of PONV in patients at high risk of Post-operative Nausea and Vomiting (PONV).
- Trial name
- NCT02337062
- Testing
- APD421
- Where
- 25 sites in United States, France and 1 more
- Volunteers
- 1,147 people
- Sponsor
- Acacia Pharma Ltd
Preventing of Postoperative Nausea and Vomiting in Adults
A Trial of HRS5580 in Prevention of Postoperative Nausea and Vomiting of Adults
The study is being conducted to evaluate the efficacy, and safety of HRS5580 for preventing of postoperative nausea and vomiting in adults. To explore the reasonable dosage of HRS5580 for postoperative nausea and vomiting.
- Trial name
- NCT06475846
- Testing
- HRS5580, Ondansetron, blank preparation
- Where
- 2 sites in China
- Volunteers
- 235 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
PONV
A Comparison of the Efficacy of Amisulpride and Placebo in the Prevention of PONV in Patients at Moderate-to-high Risk of PONV.
A comparison of the efficacy of Amisulpride and placebo in the prevention of PONV in patients at moderate-to-high risk of PONV.
- Trial name
- NCT05822713
- Testing
- Amisulpride
- Volunteers
- 516 people
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Postoperative Nausea and Vomiting
Pilot Study to Assess Palonosetron Versus Ondansetron as Rescue Medication in Subjects That Develop Postoperative Nausea and Vomiting (PONV) in the Postanesthesia Care Unit (PACU)
The purpose of this study is to investigate palonosetron versus ondansetron as rescue medication in subjects that develop postoperative nausea and vomiting (PONV) in the Postanaesthesia Care Unit (PACU).
- Trial name
- NCT00967499
- Testing
- Ondansetron, Palonosetron
- Where
- 8 sites in United States
- Volunteers
- 239 people
- Sponsor
- Eisai Inc.
Postoperative Nausea and Vomiting
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
The goal of this Interventional study is to evaluate the efficacy and safety of Aprepitant Injection(QLG2174) for preventing PONV in Chinese patients.
- Trial name
- NCT06932107
- Testing
- Aprepitant Injection
- Where
- China
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Postoperative Nausea and Vomiting (PONV)
A Study of TAK-951 to Stop Adults Getting Nausea and Vomiting After Planned Surgery
Some adults are at a higher risk of feeling sick (nausea) or being sick (vomiting) after they have surgery. In this study, these adults will have planned surgery.
- Trial name
- NCT04557189
- Testing
- TAK-951, Ondansetron
- Where
- 7 sites in United States
- Volunteers
- 89 people
- Sponsor
- Takeda
Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV)
A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults
A Study to Compare the Bioavailability of Ondansetron Following Nasal (NS003) and IV Administration in Healthy Adults
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-induced Nausea and Vomiting (RINV), Postoperative Nausea and Vomiting
- Trial name
- NCT07868861
- Testing
- NS003 Ondansetron HCl microspheres powder for nasal application, Ondansetron Solution for IV infusion 8mg
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nasus Pharma
Post-operative Nausea and Vomiting (PONV)
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
A randomized, double-blind, placebo-controlled, multi-center phase III study to compare the efficacy and safety of aprepitant injection and placebo in the prevention of post-operative nausea and vomiting (PONV).,
- Trial name
- NCT06543966
- Testing
- Aprepitant Injection
- Volunteers
- 486 people
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.