Clinical trials: Post-Surgical Complication
Laparotomy Closure After Abdominal Surgery, Suture Materials
Comparison of Vicryl Versus Prolene for Midline Rectus Sheath Closure After Elective Laparotomy
This randomized controlled trial compared two commonly used suture materials, Prolene and Vicryl, for closing the midline rectus sheath after elective laparotomy.
- Conditions
- Laparotomy Closure After Abdominal Surgery, Suture Materials, Complications Wounds
- Trial name
- NCT07451990
- Testing
- Vicryl (Polyglactin 910) Suture, Prolene (Polypropylene) Suture
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- Hayatabad Medical Complex
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
TME, Rectal Cancer Surgery
REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department
The purpose of this multicenter randomized non-inferiority trial is to evaluate the safety of low anterior resection for rectal cancer performed with versus without a diverting stoma in patients with a low predicted risk of…
- Conditions
- TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer
- Trial name
- RELOAD (NCT07463261)
- Testing
- Without a preventive stoma, With a preventive stoma
- Where
- 7 sites in Russia
- Volunteers
- 442 people
- Sponsor
- ANO Scientific and Practical Club for the Development of Modern Medical Technologies
Intraoperative Hypotension, Pulmonary Complication
Perioperative Goal Directed Therapy (PGDT) in Spinal Surgery in the Prone Position
This study aims at evaluating if a specific protocol, that can be framed in the innovative concept of Perioperative Goal Directed Therapy (PGDT), based on the evaluation of the Stroke Volume Variation (SVV) - a parameter deriving…
- Conditions
- Intraoperative Hypotension, Pulmonary Complication, Cardiovascular Complication
- Trial name
- PGDT (NCT04025086)
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University of Catania
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Effects a Rehabilitation Program in Patients With Left Ventricular Dysfunction After Coronary Artery Bypass Grafting
This study aims to analyze effects of three types of cardiac rehabilitation protocol on fuctional capacity, inflammatory markers, pulmonary function and clinical outcomes after coronary artery bypass grafting (CABG) in patients…
- Trial name
- NCT02763774
- Testing
- Walking exercise, Stationary cycling exercise, Neuromuscular electrical stimulation
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Federal University of São Paulo
Muscle Loss
Branched Chained Amino Acid Supplement in Patients Undergoing Lower Limb Bone Cancer Curettage for Bone Metastasis
Postoperative muscle loss is common in patients with bone metastases undergoing lower limb bone cancer curettage, affecting both limb skeletal muscles and potentially swallowing-related muscles.
- Trial name
- NCT06604910
- Testing
- branched chained amino acid
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Vasoplegia, Cardiac Surgery
Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)
Vasoplegia is an important determinant for adverse postoperative outcome and is observerd in 5% to 54% of patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).
- Trial name
- CORTIVAS-CS (NCT04301479)
- Testing
- hydrocortisone sodium succinate, Saline
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Instituto do Coracao
Post-cardiac Surgery, Blood Transfusion Complication
Perioperative Risk Factors of Outcomes for Cardiac Surgery: A Retrospective Study
Based on a review of about 10,000 patients undergoing cardiac surgery under CPB in West China Hospital of Sichuan University and the Second Affiliated Hospital of Zhejiang University, we try to evalute the effect of blood…
- Conditions
- Post-cardiac Surgery, Blood Transfusion Complication, Prognosis
- Trial name
- NCT04980742
- Testing
- acute normovolemic hemodilution
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Knee Arthropathy, Post Operative Pain
Function and Pain Following Knee Replacement
The goal of this interventional study is to compare pain management techniques (femoral nerve block, intra-articular block, none) in TKA patients.
- Conditions
- Knee Arthropathy, Post Operative Pain, Pain, Postoperative
- Trial name
- NCT05478005
- Testing
- Femoral nerve block, Intra-articular block
- Where
- Israel
- Volunteers
- 54 people
- Sponsor
- University of Haifa
Postoperative Nausea and Vomiting, Nausea and Vomiting, Postoperative
A Study To Evaluate An NK-1 Antiemetic For The Prevention Of Post Operative Nausea And Vomiting
This study is looking at a range of doses of this NK-1 receptor antagonist drug, for both safety and effectiveness in prevention PONV
- Trial name
- NCT00108095
- Testing
- intravenous ondansetron
- Where
- 58 sites in United States, Belgium and 4 more
- Volunteers
- 701 people
- Sponsor
- GlaxoSmithKline
Post Operative Pain, Acute
Comparison Between the Analgesic Effect of Fascia Transversalis Block vs Caudal Block
Despite the growing interest in interfascial blocks and their successful use in pediatric surgeries, no previous randomized clinical trials have directly compared the analgesic efficacy, opioid-sparing effect, and safety profile…
- Trial name
- NCT07235475
- Testing
- Caudal Block Anesthesia, Fascia Transversalis Block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Body Weight, Post-Op Complication
Development of Machine Learning Models for the Prediction of BMI and Complications After Bariatric Surgery (CABS-Study)
This Study aims to develop machine learning models with the ability to predict patients' BMI and complications after Bariatric Surgery (CABS-Score).
- Conditions
- Body Weight, Post-Op Complication, Anastomosis, Leaking, Hiatal Hernia
- Trial name
- NCT05710913
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Pain, Postoperative, Shoulder Osteoarthritis
Effective Pain Management During Shoulder Replacement Surgery With EXPAREL
The purpose of this study is to examine the effectiveness of post-operative pain control of local infiltration (LIA) of EXPAREL administration to ropivacaine administered via continuous interscalene nerve block (CINB) for…
- Trial name
- NCT03474510
- Testing
- local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block
- Where
- United States
- Sponsor
- TriHealth Inc.
Ovarian Cancer
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug with peripheral stem cell transplantation may allow the doctor to give higher…
- Trial name
- NCT00003413
- Testing
- filgrastim, carmustine, cisplatin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Maryland, Baltimore
Perioperative Care, Postoperative Complications
Postoperative Outcomes Within an Enhanced Recovery After Bariatric Surgery Protocol
Methods National audit of a 90-day prospective observational cohort in which pre-defined postoperative complications were analyzed at 30 days of follow-up in adult patients undergoing elective bariatric surgery with or without an…
- Conditions
- Perioperative Care, Postoperative Complications, Bariatric Surgery Candidate
- Trial name
- POWER3 (NCT03864861)
- Where
- 53 sites in Spain
- Volunteers
- 460 people
- Sponsor
- Grupo Español de Rehabilitación Multimodal
Postoperative Pain, Video-Assisted Thoracoscopic Surgery
US-Guided SAPB Versus ESPB on Acute and Chronic Pain After VATS
Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary…
- Conditions
- Postoperative Pain, Video-Assisted Thoracoscopic Surgery, Serratus Anterior Plane Block, Erector Spinae Plane Block
- Trial name
- NCT05160961
- Testing
- Serratus anterior plane block, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Cholelithiases, Nursing Caries
The Effect of Early Mobilization and Fluid Consumption on Bowel Movements After Cholecystectomy
Objective: The aim of this study was to determine the effect of early mobilization with consumption of tea, coffee, and warm water on bowel movements in patients who had laparoscopic cholecystectomy surgery.
- Conditions
- Cholelithiases, Nursing Caries, Perioperative Complication, Bowel Ileus
- Trial name
- NCT05800886
- Testing
- Early mobilization and tea consumption, Early mobilization and coffee consumption, Early mobilization and warm water consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Gazi University
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Complications, Surgery
Acupuncture-assisted-anesthesia to Improve Postoperative Outcome After Digestive Surgery in Elderly Patients
The investigators assume that transcutaneous electric acupoint stimulation (TEAS) pretreatment may activate the endogenous protective mechanism, as a result protect the patients against subsequent surgical stress pregnancy.
- Trial name
- AID (NCT02239159)
- Testing
- TES(transcutaneous electric stimulation)
- Where
- China
- Volunteers
- 748 people
- Sponsor
- Air Force Military Medical University, China