Clinical trials: Post-Traumatic Stress
PTSD
Transcendental Meditation in Veterans and First Responders With PTSD
The present study is part of a Phase 3 multi-site clinical trial that will recruit veterans and first responders diagnosed with PTSD, where they will be randomized to receive either Transcendental Meditation (TM) or Present…
- Trial name
- NCT05645042
- Testing
- Transcendental Meditation (TM), Present Centered Therapy (PCT)
- Where
- 5 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Post-traumatic Stress Disorder (PTSD), Trauma
Kappa Opioid Receptor Imaging in Post-traumatic Stress Disorder (PTSD)
This study uses positron emission tomography (PET) imaging to measure kappa opioid receptors (KOR) in the brains of individuals with and without post-traumatic stress disorder (PTSD).
- Trial name
- NCT02237703
- Testing
- Positron emission tomography (PET) imaging
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Posttraumatic Stress Disorder
Testing of a Mobile Web App to Decrease Posttraumatic Stress Symptoms in Women After Sexual Assault
Interventions are available to all adult women sexual assault survivors to reduce the risk of pregnancy and sexually transmitted infection, yet no interventions are provided to reduce posttraumatic stress.
- Trial name
- NCT04334356
- Testing
- Mobile Web App
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Pregnancy Loss
ACTRAMAT-D: Impact of Post-Traumatic Stress Disorder After Pregnancy Loss After 12 Weeks of Gestation
In France The prevalence of Pregnancy Loss after 12 weeks of gestation is around 3%. This situation is probably associated to a risk of post-traumatic stress disorder.
- Trial name
- ACTRAMAT-D (NCT03433989)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Posttraumatic Stress Disorder
The Effectiveness of CFT for Reducing Self-criticism in Patients With Complex PTSD: a Single-case Experimental Study
PTSD is a mental disorder including psychological symptoms related to severe traumatic event(s). PTSD can negatively affect people's functioning in several life domains.
- Trial name
- NCT05791760
- Testing
- Compassion-focused therapy (CFT) for complex PTSD
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Twente
Posttraumatic Stress Disorder, PTSD
TDCS-Augmented Prolonged Exposure Therapy
The purpose of this study is to determine the effects of a brain stimulation technique known as transcranial direct current stimulation, or tDCS, on the benefits of Prolonged Exposure therapy, or PE, which is an effective…
- Conditions
- Posttraumatic Stress Disorder, PTSD, Anxiety, Depression
- Trial name
- NCT04327362
- Testing
- Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post-traumatic Stress Disorder
Qualitative Study on the Perception of Changes in the Psychotherapy of Traumatized Young People
The clinic of psychological trauma in adolescents still requires further development, whereas it is well documented in adults. This clinic is complex, because it must take into account the nature and type of trauma (recent or…
- Trial name
- TRAUMADOPSY (NCT06138522)
- Testing
- Semi-structured interviews, Child Post-Traumatic Stress Response Index (CPTS-RI) scale, - Therapeutic Alliance Questionnaire (HAQ-CP)
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PTSD, Substance Use Disorders
COPEWeb Training for Providers
Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans.
- Trial name
- COPEWeb (NCT05812131)
- Testing
- COPEWeb online training, COPE In Person
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Fibromyalgia, Posttraumatic Stress Disorder
Fibromyalgia in Men Suffering From PTSD
Assessing FM and psychiatric state among PTSD, MDD and healthy participants
- Conditions
- Fibromyalgia, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00229294
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cancer, Depression
FOCUS:Families OverComing Under Stress
The FOCUS program (study treatment) is an established evidence-based intervention whose redesign for families and couples dealing with serious and chronic illnesses will provide a creative and promising supplement to the existing…
- Conditions
- Cancer, Depression, PostTraumatic Stress Disorder, Anxiety
- Trial name
- NCT02992405
- Testing
- FOCUS Resilience Enhancement Program, Waitlist (No Study Treatment)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Stress Disorders, Post-Traumatic
The Effect of EFT on Psychological States in a Veterans Population
A need exists to find fast yet effective treatment protocols for the large number of US military service personnel coming back from Iraq with post traumatic stress disorder (PTSD), and a variety of co-occurring psychological…
- Trial name
- NCT00743041
- Testing
- Emotional Freedom Techniques (EFT)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post-Traumatic Stress Disorder
Role of Substance P in Post-Traumatic Stress Disorder
This study will examine the role of substance P, a chemical messenger in the brain, in post-traumatic stress disorder (PTSD), a chronic anxiety disorder.
- Trial name
- NCT00102102
- Testing
- [18F]SPA-RQ
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety, PTSD
A Scalable Model for Promoting Functioning and Well-Being Among Veterans With a History of Mental Health Challenges Via Meaningful Social Interactions: Project V-SPEAK!
The goal of this study is to refine and test a strategy for engaging veterans with symptoms of depression and/or anxiety as volunteers to help English language learners (ELLs) improve their speaking skills via structured…
- Trial name
- V-SPEAK! (NCT05506839)
- Testing
- Intervention (videoconferencing)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Post-Traumatic Stress Disorder, PTSD, Alcohol Use Disorder (AUD)
Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974
Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer [18F]PF974
- Trial name
- NCT07488819
- Testing
- PF974
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Yale University
Brain Injuries, Traumatic, Post-traumatic Stress Disorder
Morning Bright Light to Improve Sleep Quality in Veterans
One of the principal complicating factors associated with traumatic brain injury (TBI) is sleep-wake disturbances (e.g., insomnia, excessive daytime sleepiness, and circadian rhythm sleep disorders).
- Trial name
- NCT03578003
- Testing
- Morning Bright Light Therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Portland VA Medical Center
Substance Use Disorders, Drug Abuse
Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users
The unmet need for effective addiction treatment within the criminal justice system "represents a significant opportunity to intervene with a high-risk population" according to NIDA's 2016-2020 strategic plan.
- Conditions
- Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT04007666
- Testing
- Cognitive Processing Therapy, Control Group
- Where
- 2 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Post Traumatic Stress Disorder, Smoking
Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
This project assesses the usability and feasibility of a multi-behavioral computerized, tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms.
- Conditions
- Post Traumatic Stress Disorder, Smoking, Anxiety, Depression
- Trial name
- CTI-PTSD (NCT01510834)
- Testing
- Multibehavioral, Computerized Tailored Intervention STR2IVE
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System