Clinical trials: Post-extubation Respiratory Failure
Neonatal Respiratory Failure
Non Invasive Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants.
The purpose of this study is to determine whether Nasal intermittent positive pressure ventilation (NIPPV) non synchronized is better than continuous positive airway pressure (NCPAP)in preventing extubation failure within 72 h…
- Trial name
- VNINS (NCT01778829)
- Testing
- CPAP ventilation mode, NIPPV ventilation mode
- Where
- Chile
- Volunteers
- 220 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative
Peri-operative BiPAP to Prevent Tracheostomy in High-Risk Bilateral Vocal-Cord Paralysis (BVCP)
Why: After thyroid or neck surgery, some patients can lose movement of both vocal cords (bilateral vocal-cord paralysis, BVCP). This can make breathing difficult and often leads to an emergency or preventive tracheostomy…
- Conditions
- Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative, Thyroid Neoplasms, Sleep Apnea, Obstructive
- Trial name
- BVCP-BiPAP (NCT07042971)
- Testing
- Pre-operative BiPAP Training, Post-extubation BiPAP Support, Standard Peri-operative Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Fujian Medical University
Obesity, Respiratory Failure
Wean Obese Study : Determination of the Optimal Spontaneous Breathing Trial for Obese Patient
The decision to extubate a patient after acute respiratory failure is based on clinical observation and measurement of pulmonary mechanics. Current extubation criteria(tidal volume, respiratory frequency...) lack of specificity.
- Conditions
- Obesity, Respiratory Failure, PSV 7cmH2O PEEP 7cmH2O, PSV 7 cmH2O PEEP 0 cmH20
- Trial name
- NCT01616901
- Testing
- Spontaneous breathing trial
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Montpellier
Hypoxemic Respiratory Failure
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia
In this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (PTIF) pre and post…
- Trial name
- NCT04971148
- Testing
- HFNC flow set at patient peak tidal inspiratory flow, HFNC flow set at 1.33 times of patient peak tidal inspiratory flow, HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
- Where
- 2 sites in United States, Spain
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Extubation Failure, Acute Respiratory Failure Post Extubation
Prevention of Reintubation by Using Noninvasive Positive Pressure Ventilation
Child extubation failure range from 4.1% to 19%. Studies in adults and children showed that extubation failure increases mortality mainly in those who need reintubation as this is a invasive procedure associated with many…
- Trial name
- NCT00977002
- Testing
- Positive Pressure Noninvasive ventilation, Inhalatory O2
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Post-extubation Failure, Persistent Weaning Failure
Effects of Mechanical Insufflation-Exsufflation in Preventing Respiratory Failure After Extubation
Weaning protocols that include the use of noninvasive ventilation (NIV), decreases the incidence of re-intubation and ICU length of stay. However, the role of NIV in post-extubation failure is still not clear.
- Conditions
- Post-extubation Failure, Persistent Weaning Failure, Secretion Encumbrance, Weak Cough
- Trial name
- MIEICU (NCT01424202)
- Testing
- Mechanical Insufflation Exsufflation
- Where
- Portugal
- Volunteers
- 92 people
- Sponsor
- Hospital Sao Joao
Acute Respiratory Failure
Global Physiotherapy in ICU Patients With High Risk Extubation Failure
This study aims to compare care provided by physiotherapists, combining respiratory care and early rehabilitation in intensive care unit, with standard care on the rate of acute respiratory failure within 7 days after extubation…
- Trial name
- KINEXTUB (NCT05423301)
- Testing
- Experimental, Control
- Where
- France
- Volunteers
- 245 people
- Sponsor
- University Hospital, Bordeaux
Extubation Failure in Neonates
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation After Extubation in Neonates
The goal of this clinical trial is to learn which breathing support works better after removing a newborn's breathing tube. Researchers will study newborns born at 26 weeks of gestation or later.
- Trial name
- NOV-A (NCT07836166)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Aga Khan University
Acute Brain Injury, Post-neurosurgical Status
High-Flow Nasal Cannula After Extubation in Acute Brain Injury
Patients with acute brain injury after neurosurgery are at increased risk of extubation failure after removal of the endotracheal tube.
- Conditions
- Acute Brain Injury, Post-neurosurgical Status, Extubation Failure, Postoperative Respiratory Complications
- Trial name
- NCT07664085
- Where
- Vietnam
- Volunteers
- 285 people
- Sponsor
- Bach Mai Hospital
Respiratory Insufficiency
Nasal High Frequency Oscillatory Versus Nasal Intermittent Positive Pressure Ventilation in Neonate After Extubation
To evaluate the efficacy and safety of nasal high frequency oscillatory ventilation(NHFOV) in preterms with respiratory disease syndrome(RDS) after extubation.
- Trial name
- NCT02543125
- Testing
- NIPPV, NHFOV
- Volunteers
- 75 people
- Sponsor
- Gao WeiWei
Respiratory Insufficiency of Prematurity
Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study)
Despite widely used of nasal CPAP in preterm infants, uncertainties regarding aspects of its application remain. Clinical indications vary greatly between institutions, especially when combined with varieties of systems, devices…
- Trial name
- L-CPAP (NCT00636324)
- Testing
- Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Patients With Acute Hypercapnic Respiratory Failure
Weaning Form Mechanical Ventilation Using Extracorporeal CO2 Removal
Weaning from invasive mechanical ventilation is one of the major clinical problem especially ion those patients with a pre-existing chronic respiratory disease and chronic hypercpania.
- Trial name
- WeanPRO (NCT02259335)
- Testing
- Extracorporeal CO2 removal device
- Where
- 2 sites in Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD
High-Flow Nasal Cannula Versus Noninvasive Ventilation After Extubation in Patients With COPD and Mild Hypercapnic Respiratory Failure
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent a leading cause of hospital admissions and respiratory intensive care unit (RICU) stays worldwide.
- Trial name
- NCT07381686
- Testing
- Non-Invasive Ventilation (NIV), High-Flow Nasal Cannula (HFNC)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Extubation Failure
Post-extubation High-flow Nasal Oxygen for Preventing Extubation Failure
Patients intubated due to acute respiratory failure have a high risk of infectious complications, airway injuries and multiple organic failure, so performing a successful extubation from mechanical ventilation is key.
- Trial name
- NCT03361683
- Testing
- High-flow nasal oxygen, Venturi mask
- Where
- Mexico
- Volunteers
- 127 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Premature, Respiratory Distress Syndrome
Post-extubation Use RAM Cannula Versus Short Binasal Prong Interfaces in Preterm Infants
Nowadays, the use of non-invasive ventilation for preterm infants in the NICU has increased to avoid complications associated with prolonged endotracheal intubation.
- Conditions
- Premature, Respiratory Distress Syndrome, Extubation
- Trial name
- NCT07113535
- Testing
- RAM cannula, Short binasal prong
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Ministry of Health, Saudi Arabia
Post Extubation Respiratory Failure
The Effectiveness of High Flow Nasal Cannula Versus Noninvasive Ventilation and Conventional Oxygen Therapy
A prospective, randomized controlled study enrolling sixty patients who fulfilled weaning criteria after requiring invasive MV. After extubation, patients were randomized into three groups (20 patients per group) :NIV group …
- Trial name
- NCT06593509
- Testing
- Maquet,Servo I., Vapotherm, venturi mask
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Respiratory Failure
Nasal High-flow Versus Venturi Mask Oxygen Therapy in the Post-extubation Period
The aim of the study is to compare two devices for oxygen therapy, nasal high-flow and Venturi mask, in critically ill patients in the post-extubation period.
- Trial name
- NCT01575353
- Testing
- Venturi mask, Nasal high-flow
- Where
- 2 sites in Italy
- Volunteers
- 105 people
- Sponsor
- Catholic University of the Sacred Heart