Clinical trials: Post-op Pain
Lumbar Spine Surgery, Chronic Low-back Pain
Telehealth Mindfulness After Spine Surgery
The goal of this pilot clinical trial is to compare two behavioral interventions for patients who are recovering from lumbar spinal surgery for a degenerative spine condition. The study aims to answer the following questions: 1.
- Conditions
- Lumbar Spine Surgery, Chronic Low-back Pain, Postsurgical Pain
- Trial name
- NCT05698914
- Testing
- Telehealth mindfulness-based intervention (MBI), Telehealth Education
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Pain
Superficial Cervical Plexus Block and Quality of Recovery After Thyroidectomy
The goal of this clinical trial is to learn whether a superficial cervical plexus block improves quality of recovery after thyroid surgery.
- Trial name
- QoR-SCPB (NCT06002152)
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Yale University
Laparoscopic Surgery
Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
This study proposes to investigate the effects of labetalol or esmolol on managing the vital signs (like blood pressure and heart rate) during surgery, on pain management, and on the later recovery after surgery.
- Trial name
- NCT01114971
- Testing
- Fentanyl, Labetalol, Esmolol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Postoperative
Perioperative Administration of Pregabalin for Pain After Mastectomy
The investigators hypothesize that pregabalin will decrease post-operative pain scores and analgesic use following total mastectomy compared to placebo.
- Trial name
- NCT00938548
- Testing
- Pregabalin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Severance Hospital
Pain, Postoperative, Mammaplasty
Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty
The addition of dexamethasone to non-liposomal bupivacaine in perineural blocks has been shown to enhance pain control and prolong the time until first request for postoperative narcotics in the fields of orthopedic, thoracic…
- Trial name
- NCT04919317
- Testing
- Dexamethasone 4mg, Saline
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Temple University
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Bariatric Surgery Candidate, Pain, Postoperative
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
This study is prospective, randomized trial in which the efficacy of liposomal bupivacaine (Exparel®) is compared to standard bupivacaine local surgical site injection in reducing total IV and oral morphine equivalents required…
- Trial name
- Exparel (NCT03196505)
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Postoperative Pain
A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
The purpose of this study is to compare the efficacy of pregabalin to placebo for postoperative pain control after photorefractive keratectomy.
- Trial name
- NCT01097577
- Testing
- pregabalin
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- 59th Medical Wing
Pain, Postoperative, Postoperative Nausea and Vomiting
Dexamethasone for Post-cesarean Delivery Pain
The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative…
- Trial name
- NCT01812057
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University
Pain, Postoperative
Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)
The purpose of this study was to evaluate the efficacy and safety of Etoricoxib compared to placebo and ibuprofen in the treatment of postoperative pain associated with unilateral total knee replacement surgery.
- Trial name
- NCT00820027
- Testing
- Etoricoxib 90 mg, Etoricoxib 120 mg, Ibuprofen 600 mg
- Volunteers
- 776 people
- Sponsor
- Organon and Co
Postoperative Pain
Morphine Added to Ropivacaine for FICB for Postoperative Analgesia
prospective, randomized double blinded study to investigate the effects of morphine as an adjuvant to ropivacaine on FICB
- Trial name
- NCT03875274
- Testing
- Ropivacaine, Morphine, Ropivacaine, Saline
- Where
- Nepal
- Volunteers
- 70 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Chronic Rhinosinusitis
Microcurrent Device (TIVIC Health)
The purpose of this study is to investigate whether daily use of a microcurrent neuromodulation device, which applies a small current of electricity to the forehead and maxillary region, will decrease the pain experienced by…
- Trial name
- NCT05198518
- Testing
- Microcurrent TENS device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post Operative Pain
Trial of Extended Release Bupivacaine for Pain Relief After Surgery
This is a research study of SABER® -Bupivacaine, an experimental medication designed to reduce pain for up to 3 days after surgery.
- Trial name
- PERSIST (NCT02574520)
- Testing
- SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Bupivacaine HCl
- Where
- 21 sites in United States
- Volunteers
- 399 people
- Sponsor
- Durect
Cystectomy
Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy
The purpose of this study is to compare the difference between four different pain control methods in patients who will be having a cystectomy surgery (surgical removal of the bladder).
- Trial name
- NCT04300231
- Testing
- epidural bupivacaine 0.05%, Liposomal bupivacaine, bupivacaine 0.125%
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Indiana University
Pain, Postoperative, Hernia, Inguinal
Surgical Pain After Inguinal Hernia Repair (SPAIHR)
The purpose of this study is to test whether pregabalin added to the standard of care with dosing starting preoperatively and continuing for 1 week post surgery will decrease the intensity of acute post-operative pain following…
- Trial name
- NCT00551135
- Testing
- Pregabalin
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 425 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Persistent Post-surgical Pain, Acceptance and Commitment Therapy
Preventing Persistent Post-Surgical Pain and Opioid Use In At-Risk Veterans: Effect of ACT
A large number of veterans suffer from distress-based conditions, such as anxiety and depression, putting them at high risk of experiencing persistent pain and prolonged opioid use following surgery.
- Conditions
- Persistent Post-surgical Pain, Acceptance and Commitment Therapy, Substance Use Disorder
- Trial name
- PreACT (NCT02437188)
- Testing
- ACT (Acceptance and Commitment Therapy)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Barbara A Rakel
Postoperative Pain
Study of the Safety, Tolerability and Analgesic Efficacy of Multiple Doses of Ketorolac Tromethamine (IN) for Postoperative Pain
This was a randomized, double blind, placebo-controlled study in subjects who have undergone major surgery. Each subject's study participation consisted of a screening visit, a 2-day treatment period, and a follow-up visit.
- Trial name
- NCT01351090
- Testing
- Ketorolac tromethamine
- Where
- New Zealand
- Volunteers
- 127 people
- Sponsor
- American Regent, Inc.
Persistent Postsurgical Pain
Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement
Osteoarthritis (OA) is the single most common cause of disability in mid and late life. About 27 million people in the United States suffer from this incurable process and 10 million have OA of the knee.
- Trial name
- PPP-TKA (NCT01320150)
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Rush University Medical Center
Pain, Postoperative
Role of Propolis Paste in Preventing Pain After Root Canal Treatment.
This study evaluates the role of propolis paste as compared to calcium hydroxide (when used as intracanal medication) in prevention and treatment of pain after root canal treatment in necrotic (infected) teeth.
- Trial name
- NCT03723980
- Testing
- Propolis, Calcium Hydroxide
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Juzer Shabbir Saifee