Clinical trials: Post-operation Delirium
Postoperative Insomnia, Postoperative Delirium
Efficacy of Suvorexant on Post-operative Sleep Disturbance
The study is a parallel group, double blind, randomized trial. Subjects will be recruited from individuals undergoing elective surgery for orthopedic, abdominal, urologic, gynecologic or spine reasons.
- Trial name
- NCT05823844
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Postoperative Delirium (POD), Prostate Cancer
A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery
Cases were included based on the inclusion and exclusion criteria, and induction, maintenance, and recovery were conducted in accordance with the standard protocol for general anesthesia.
- Conditions
- Postoperative Delirium (POD), Prostate Cancer, Kidney Tumor
- Trial name
- NCT07480044
- Testing
- Transcranial Magnetic Stimulation Device
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Zhejiang University
Cardiac Surgery, Delirium - Postoperative
Effect of Hyperoxia or Hypoxemia on the Incidence of Delirium in Patients After Cardiac Surgery
Our goal was to study the effect of hyperoxia or hypoxemia on the incidence of delirium in patients after cardiac surgery.
- Conditions
- Cardiac Surgery, Delirium - Postoperative, Hyperoxia, Hypoxemia
- Trial name
- NCT07548905
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Southeast University, China
Post Operative Delerium
The Effect of Dexmedetomidine Infusion Alone Versus the Combination of Dexmedetomidine and Melatonin on Reduction of Post-operative Delirium (POD) After Open Brain Surgeries
The aim of this study is to illuminate the effect of combination of dexmedetomidine and oral melatonin versus the use of dexmedetomidine infusion alone on the improving of post-operative delirium (POD) on patients undergoing open…
- Trial name
- NCT07475156
- Testing
- Dexmedetomidine (DEX), Melatonin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Delirium on Emergence
Ketofol for Preventing Postoperative Delirium in Elderly Patients
Delirium is a cognitive disturbance characterized by acute and fluctuating impairment in attention and awareness. Although its incidence in the general surgical population is 2-3%, it has been reported to occur in up to 10-80% of…
- Trial name
- NCT04816162
- Testing
- ketofol, dexmedetomidine, normal saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Cardiac Disease
Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery
Delirium after cardiac surgery is reported in a range of 3-47% of patients. Delirium is a serious complication that results in prolonged length of stay, increased health care costs and is associated with higher death rates.
- Trial name
- NCT01707446
- Testing
- Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter), An alarm threshold at 75% of the baseline rSO2 value
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University Health Network, Toronto
Delirium, Hip Fracture
Evaluating the Addition of Regional Analgesia to Reduce Postoperative Delirium in Patients Having Hip Fracture Surgery.
Post operative delirium is common after hip fracture surgery and is associated with increased length of hospital stay, delayed recovery and increased mortality.
- Trial name
- RASAPOD (NCT02689388)
- Testing
- Femoral Nerve Block
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Auckland City Hospital
Older Patients, Nasal Administration
Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium
Emergence delirium is common in older patients after surgery and associated with worse perioperative outcomes, including increased postoperative delirium.
- Conditions
- Older Patients, Nasal Administration, Dexmedetomidine, Esketamine
- Trial name
- NCT06566469
- Testing
- Dexmedetomidine, Esketamine, Normal saline
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Peking University First Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Post-Operative Delirium
A Study to Evaluate ICU Simulation Experience in the Cardiothoracic Surgical Population to Reduce Post-operative Delirium
The purpose of this study is to evaluate the effect of a pre-ICU admission virtual reality ICU simulation on post-operative delirium in the elective cardiothoracic surgical population while in the intensive care unit.
- Trial name
- NCT05159648
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Mayo Clinic
Emergence Delirium
Effects of Remifentanil Infusion on Emergence Delirium After Dental Surgery in Children
In this study, the investigators tried to show the effect of remifentanil on emergence delirium caused by sevoflurane used in general anesthesia.We planned a retrospective study. We formed two groups of 80 participants.
- Trial name
- NCT04300374
- Testing
- The Paediatric Anaesthesia Emergence Delirium scale assesment which was recorded postoperatively
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erzincan University
Delirium
Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery
In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.
- Trial name
- NCT00699946
- Testing
- olanzapine
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
Intensive Care, Surgical
Postoperative Delirium in Adult Patients After Elective Craniotomy Under General Anaesthesia
Postoperative delirium may result in many adverse complications. At present little is known about postoperative delirium in patients after crniotomy because they may manifest similar symptoms to definitely delirium for some…
- Conditions
- Intensive Care, Surgical, Postoperative Care, Neurosurgery
- Trial name
- NCT03087838
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Capital Medical University
Delirium
Rivastigmine for the Prevention of Postoperative Delirium in Patients Undergoing Cardiac Surgery
The purpose of this study is to determine whether Rivastigmine is effective for the prevention of postoperative delirium in patients undergoing cardiac surgery.
- Trial name
- NCT00257868
- Testing
- Rivastigmine prevention of delirium
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Delirium, Adult Cardiac Surgery
Incidence of Postoperative Delirium After Cardiac Surgery in Adults.
Postoperative delirium is an acute syndrome of mental deterioration characterized by acute onset and fluctuating course during the day.
- Conditions
- Postoperative Delirium, Adult Cardiac Surgery, Covid19
- Trial name
- NCT04828902
- Testing
- cardiac surgery
- Where
- Poland
- Volunteers
- 610 people
- Sponsor
- Medical University of Gdansk
Emergence Agitation
Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation
The aim of this randomized double-blinded study is to determine whether transition to propofol for 3 min at the end of sevoflurane anaesthesia reduces the incidence of EA in children undergoing genito-urinary paediatric surgeries.
- Trial name
- NCT03179293
- Testing
- Propofol, Normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Carcinoma, Non-Small-Cell Lung, Surgery--Complications
Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery
Delirium is a common complication in elderly patients after surgery. And its occurrence is associated with worse outcomes. The causes of delirium are multifactorial but may include pain, stress response and inflammation.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Surgery--Complications, Dexamethasone, Flubiprofen Axetil
- Trial name
- NCT03200600
- Testing
- Dexamethasone, Normal saline, Flurbiprofen axetil
- Where
- 2 sites in China
- Volunteers
- 126 people
- Sponsor
- Peking University First Hospital
Delirium, AAA
Abdominal Aortic Aneurysm Patients Remain at Risk for Delirium on the Surgical Ward After Intensive Care Unit Dismissal
The incidence of delirium following open abdominal aortic aneurysm (AAA) surgery is significant, with incidence rates ranging from 12 to 33%.
- Conditions
- Delirium, AAA, Intensive Care Unit Delirium, Surgery--Complications
- Trial name
- NCT04080557
- Testing
- Surgery
- Where
- Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Amphia Hospital
Delirium, Postoperative
Reducing Delirium After CABG Surgery With Early Activation and Sleep-Promoting Routines
The goal of this randomized-controlled trial (RCT) is to compare the effectiveness of the DREAMS-OT intervention with standard care in reducing post-Coronary Artery Bypass Graft (CABG) surgery delirium in patients undergoing CABG…
- Trial name
- DREAMS-OT (NCT06107517)
- Testing
- DREAMS-OT
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- National University Hospital, Singapore