Clinical trials: Post-operation Delirium
Delirium, Cognitive Decline
Dexmedetomidine Use in ICU Sedation and Postoperative Recovery in Elderly Patients and Post-cardiac Surgery
Increasing numbers of elderly patients are undergoing cardiac surgery. Elderly patients may have prolonged recovery following cardiac surgery when compared to other groups of patients, and are at higher risk of postoperative…
- Conditions
- Delirium, Cognitive Decline, Post-operative Quality of Recovery
- Trial name
- DIRECT (NCT02699801)
- Testing
- propofol, Dexmedetomidine
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of British Columbia
Postoperative Delirium
Prevalence and Risk Factors for Postoperative Delirium 48 Hours After Surgery
To determine the overall prevalence of postoperative delirium (POI) and its association with different risk factors in order to establish prevention plans to reduce its incidence and/or duration in Spanish hospitals.
- Trial name
- DELPO (NCT06127901)
- Testing
- Any surgery under any type of anaesthesia.
- Where
- 63 sites in Spain
- Volunteers
- 2,442 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Heart; Surgery, Heart, Functional Disturbance as Result, Anxiety
Combination of Music and Relaxing Light on the Patient's Anxiety After Cardiac Surgery in the Intensive Care Unit
Cardiac surgery is not trivial. It requires opening the thorax in certain indications: coronary artery bypass grafting, valve replacements or plasties, aortic dissection, etc.
- Conditions
- Heart; Surgery, Heart, Functional Disturbance as Result, Anxiety, Pain, Postoperative, Delirium
- Trial name
- RéaRelax (NCT05178680)
- Testing
- relaxation session combining music and soft light
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
Post-Operative Confusion, Long Term Adverse Effects
Depth of Anaesthesia and Long-term Survival: The Balanced Anaesthesia Follow-up Study
Anaesthetic depth and complications after major surgery: an international, randomised controlled trial - The BALANCED trial. In this large, international, randomised controlled trial that enrolled patients aged 60 years and over…
- Conditions
- Post-Operative Confusion, Long Term Adverse Effects, Surgery--Complications, Cognitive Dysfunction, Postoperative
- Trial name
- BALANCEDLT (NCT04965324)
- Testing
- Anaesthesia Depth
- Where
- New Zealand
- Volunteers
- 6,644 people
- Sponsor
- Auckland City Hospital
Delirium, Cognitive Dysfunction
Prediction Model of Long-term Cognitive Dysfunction and Delirium After Cardiac Surgery
Delirium is a clinical syndrome caused by normal dysfunction of the brain, characterized by reduced awareness and responsiveness to the environment, as well as orientation disorders, incoherent thinking and memory disorders.
- Trial name
- NCT05972057
- Testing
- cardiac surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Postoperative Delirium (POD), Postoperative Sleep Disturbance
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher…
- Trial name
- EPISODE (NCT06900205)
- Testing
- Esketamine, 0.9 % saline
- Where
- China
- Sponsor
- RenJi Hospital
Delirium, Thoracic Surgery
Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
This study will assess the incidence and risk factors for post-operative delirium in patients undergoing thoracotomy. Specifically, the study will assess if there is any relationship between an intra-operative decrease in brain…
- Trial name
- NCT03165539
- Testing
- Cerebral oxygen saturation monitoring
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Postoperative Complications, Postoperative Nausea and Vomiting
Electrical Acupoint Stimulation for Postoperative Recovery
This study investigates electrical acupoint stimulation (EAS) administered in peri-operation for improving postoperative recovery in elder patients, who accept knee arthroplasty.
- Conditions
- Postoperative Complications, Postoperative Nausea and Vomiting, Postoperative Infection, Postoperative Delirium
- Trial name
- EAS (NCT03249701)
- Testing
- Transcutaneous Electrical Acupoint Stimulation, Electroacupuncture
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Cardiac Surgical Procedures
Low Dose Dexmedetomidine and Delirium After Cardiac Surgery
Delirium after cardiac surgery can occur in up to 50% of the patients and has been shown to be significantly associated with increased morbidity and mortality. Advanced age is a significant risk factor of delirium.
- Trial name
- LOWDEXDEL (NCT03388541)
- Testing
- Dexmedetomidine
- Where
- Belgium
- Volunteers
- 420 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Intensive Care Unit Delirium, Cardiac Surgery
Delirium After Cardiac Surgery in Intensive Care Units
STUDY SUMMARY STUDY DESIGN The study will be conducted over twelve months in the Cardiac Intensive Care Unit (ICU) at Hammersmith Hospital, Imperial College Healthcare NHS Trust (ICHT).
- Conditions
- Intensive Care Unit Delirium, Cardiac Surgery, Post Operative Delirium
- Trial name
- DaCsi-ICU (NCT06355570)
- Testing
- Personal Pictures, Family Videos, Family Videos - Intervention as required
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College Healthcare NHS Trust
Postoperative Delirium
Predictive Value of β2-microspheres for Postoperative Delirium
This study evaluated the predictive value of β2-microspheres for postoperative delirium (POD) in the elderly after orthopedic surgery.
- Trial name
- NCT03130231
- Where
- China
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Postoperative Pain, Delirium
Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
Pain, confusion, and breaks in normal sleep cycles have been challenges commonly faced by patients after undergoing joint surgeries.
- Conditions
- Postoperative Pain, Delirium, Confusion, Sleep
- Trial name
- NCT01505465
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Delirium
EEG-TMS for Postoperative Delirium After Cardiac Surgery
This is a prospective, single-center, randomized, double-blind, sham-controlled trial evaluating the safety and efficacy of transcranial magnetic stimulation (TMS) for the treatment of postoperative delirium in patients…
- Trial name
- RECOVER-C (NCT07537725)
- Testing
- Theta Burst Stimulation (TBS)
- Volunteers
- 144 people
- Sponsor
- RenJi Hospital
Orthopedic Surgery
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients
Postoperative delirium (POD) is one of the most frequent complications after surgery in elderly patients, affecting between 20 and 40% of patients older than 60 after major surgery.
- Trial name
- DELIRLESS (NCT04335968)
- Testing
- Melatonin 4 mg
- Where
- France
- Volunteers
- 357 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Cognitive Dysfunction, Postoperative Delirium
Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium
Postoperative Cognitive Dysfunction(POCD) is commonly seen in cardiac surgery, which may lead to poor pognosis. Cerebral small vessel disease(CVSD) is refer as the main resource of delirium among elderly people.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Cerebral Small Vessel Diseases, Covert Postoperative Stroke
- Trial name
- NeuroIDEA (NCT05594966)
- Testing
- multimodal MRI
- Where
- China
- Volunteers
- 211 people
- Sponsor
- RenJi Hospital
Delirium
Avoidance of Delirium in Older Patients After Major Non-cardiac Surgery
This study is designed to compare the incidence of postoperative delirium in older patients after major non-cardiac surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group and a…
- Trial name
- ADOM (NCT01827501)
- Testing
- PulsioflexTM Monitoring
- Where
- Germany
- Volunteers
- 172 people
- Sponsor
- Technical University of Munich
Suspected Delirium After Elective or Emergency Heart Surgery, CAM-ICU Diagnosed Delirium
Evaluation if Physostigmine Reduces Symptoms in Patients Who Has Developed a Delirium in Intensive Care After a Surgery
Evaluation if physostigmine reduces symptoms in patients who has developed a delirium in Intensive care after a surgery
- Trial name
- NCT02216266
- Testing
- Physostigmine, Sodium Chloride solution
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- PD Dr. Bertram Scheller
Post Operative Delirium, Post Operative Pain
Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery.
- Conditions
- Post Operative Delirium, Post Operative Pain, Post-Op Complication, Post-cardiac Surgery
- Trial name
- IVACS (NCT06613178)
- Testing
- acetaminophen
- Where
- 8 sites in Canada
- Volunteers
- 1,100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Agitation, POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
PARO-agitation-study
Postoperative agitation is a common and serious complication in visceral and transplant surgery, associated with prolonged hospital stays and an increased risk of self-harm.
- Conditions
- Agitation, POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Anxiety After Surgery, Postoperative Pain
- Trial name
- NCT07568093
- Testing
- PARO
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Hannover Medical School
Postoperative Cognitive Dysfunction, Postoperative Delirium
A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac Surgery
The purpose of this study is to assess the feasibility of a randomized, double-blind, placebo-controlled pilot trial evaluating the effect of tropisetron on prevention of postoperative cognitive dysfunction in patients after…
- Trial name
- NCT04195204
- Testing
- Tropisetron
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Beijing Chao Yang Hospital