Clinical trials: Post-operation Delirium
Perioperative Care, EEG Power Spectra
Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery
The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks.
- Conditions
- Perioperative Care, EEG Power Spectra, Delirium - Postoperative
- Trial name
- PACU-EMERGE (NCT07533370)
- Testing
- Standard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Harrison Shong-Wen Chow
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Incidence of Postoperative Delirium
Delirium is a frequently occurred cerebral complication in elderly patients after surgery, and its occurrence is associated with worse outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012984
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Delirium
Exploring of Serum Biomarkers of Delirium After Cardiovascular Surgery
The incidence of postoperative delirium in patients after cardiovascular surgery is very high, which seriously affects the short-term and long-term prognosis of patients, but its mechanism is not clear.
- Trial name
- NCT06007755
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Huazhong University of Science and Technology
Postoperative Delirium, Postoperative Cognitive Dysfunction
Cognitive Outcome After Surgical and Transcatheter Aortic Valve Replacement
Aortic valve stenosis is one of the most common types of heart disease in the aging Western population. While surgical cardiac valve replacement (SAVR) is a standard therapy for patients with aortic stenosis, catheter-assisted…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Transcatheter Aortic Valve Replacement, Surgical Aortic Valve Replacement
- Trial name
- COSTA (NCT04535076)
- Testing
- Transcatheter Aortic Valve Implantation, Surgical Aortic Valve Replacement
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Heart and Brain Research Group, Germany
Child, Anesthesia Morbidity
A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating airway properties, has acquired widespread acceptance in children.
- Conditions
- Child, Anesthesia Morbidity, Delirium on Emergence
- Trial name
- NCT01680471
- Testing
- Midazolam 0.03mg/kg, Midazolam 0.05mg/kg
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Anam Hospital
Delirium
Incidence, Severity and Treatment of Delirium in Cardiac Surgery Patients: A Before-after Study
Delirium is a common yet under diagnosed condition in hospitalized patients, and the incidence have not previously been described in Danish cardiac surgery patients.
- Trial name
- NCT01774240
- Testing
- systematic screening and treatment of delirium
- Where
- Denmark
- Volunteers
- 230 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Intraoperative, Venous Congestion
Venous Congestion And Delirium After Cardiac Surgery
Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery.
- Conditions
- Intraoperative, Venous Congestion, Postoperative Delirium (POD), Cardiac Surgery
- Trial name
- NCT07285187
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POD assessments
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhuan Zhang
Cerebral Hypoxia, Postoperative Delirium
Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery
The aim of this study is to distinguish possible differences in frequency of delirium after Volatile Induction and Maintenance of Anesthesia and Total Intravenous Anesthesia in case of undeliberate cerebral desaturation during…
- Trial name
- NCT02133638
- Testing
- Sevoflurane, Propofol
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- Negovsky Reanimatology Research Institute
Delirium - Postoperative, Agitation
Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery
The goal of this clinical trial is to learn if a novel device (MindfulGarden) is beneficial in a population of patients undergoing cardiac surgery.
- Conditions
- Delirium - Postoperative, Agitation, Anxiety, Cardiac Surgery Recovery
- Trial name
- RESPITE (NCT07051096)
- Testing
- A novel device developed providing nature-driven responsive imagery that responds to the patient's physiological to distract, engage, and de-escalate behaviours of delirium., Routine post-operative management and standard delirium reduction measures.
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute
Benzodiazepines, Bladder Cancer
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer.
- Conditions
- Benzodiazepines, Bladder Cancer, Delirium, Surgery
- Trial name
- NCT04532606
- Testing
- Remimazolam, Propofol
- Where
- 6 sites in China
- Volunteers
- 1,128 people
- Sponsor
- Peking University First Hospital
Elderly Patients, Non-cardiac Surgery
Effects of Limb Remote Ischemic Preconditioning for Prevention of Delirium in Elderly Patients After Non-cardiac Surgery
To investigate whether limb remote ischemic preconditioning (LRIP) could safely decrease the incidence of delirium in elderly patients after non-cardiac surgery.
- Trial name
- LRIP-D (NCT03028389)
- Testing
- limb remote ischemic preconditioning(LRIP)
- Volunteers
- 611 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Delirium
The Clinical Changes Before and After Sugammadex in the Patients Undergoing Hip Surgery on the Aspect of Delirium
This study evaluated the effect of sugammadex on postoperative delirium in elderly patients undergoing hip fracture surgery. Medical records from 235 consecutive patients undergoing hip fracture surgery were retrospectively…
- Trial name
- NCT02305589
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Konkuk University Medical Center
Emergence Delirium, Delirium - Postoperative
Nebulized Dexmedetomidine for Post-Anesthesia Delirium in Preschool Children
Analyzing the effectiveness of nebulized dexmedetomidine 2 mcg/kg in reducing the incidence of post-anesthesia delirium in preschool children undergoing elective surgery with sevoflurane inhalation general anesthesia.
- Trial name
- NCT06761092
- Testing
- Nebulized Dexmedetomidine for Post-Anesthesia Delirium in Preschool Children, Nebulized 0.9% Normal Saline
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Udayana University
Delirium - Postoperative, Cardiac Surgery
Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients
Post-operative delirium is a common complication following cardiac surgery and is associated with increased 1 year mortality. Currently there are no drug therapies to prevent delirium.
- Conditions
- Delirium - Postoperative, Cardiac Surgery, Cardiac Surgery Subjects, Orexin Antagonist
- Trial name
- PROTEX (NCT06648681)
- Testing
- Lemborexant 5 mg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Delirium
Influence of Apelin Levels on Postoperative Cognitive Disorders After Orthopedic Surgery in Elderlies (APOCOGNIT)
No successful strategy is proposed to patients submitted to important surgery to reduce the incidence of postoperative cognitive disorders (POCD) onset.
- Trial name
- APOCOGNIT (NCT02574234)
- Testing
- Determination of apelin and inflammatory cytokines, Assessment of cognitive functions, Liquid sampling cerebrospinal
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Toulouse
Delirium - Postoperative, Cardiac Surgery
Cerebral Autoregulation and Delirium Study
Approximately one in four elderly patients develops postoperative delirium (POD) after cardiac surgery. POD is associated with prolonged hospitalization, increased mortality, and higher health care costs.
- Trial name
- AUTO-POD (NCT07671404)
- Testing
- Mespere NeuroOs (Mespere Life Sciences) monitor
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Delirium, C.Surgical Procedure; Cardiac
Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Postoperative delirium (POD) is a frequently occurring complication after cardiac surgery. Its occurrence is associated with worse outcomes of patients, including increased morbidity, prolonged hospital stay, increased medical…
- Conditions
- Delirium, C.Surgical Procedure; Cardiac, Postoperative Complications
- Trial name
- NCT02267538
- Testing
- dexmedetomidine hydrochloride for injection, 0.9% sodium chloride for injection
- Where
- China
- Volunteers
- 285 people
- Sponsor
- Peking University First Hospital
Emergence Delirium
Emergence Agitation of Sevoflurane in Pediatric
Low dose nalbuphine versus dexmedetomidine on prevention of emergence agitation in children
- Trial name
- NCT06830564
- Testing
- we will give the patient 0.1 mg nalbuphine 15 min before the end of the procedure, we will give the patient 0.5 mg dexmedetomidine 15 min before the end of the procedure
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Agitation
The Effect of Intravenous Fentanyl Prior the End of Surgery on Emergence Agitation in Paediatric Patients After General Anesthesia
The propose of this study is to determine the effect of intravenous fentanyl prior the end of surgery on the incidence and severity of EA in pediatric patient.
- Trial name
- NCT01440114
- Testing
- fentanyl, NSS
- Where
- Thailand
- Volunteers
- 144 people
- Sponsor
- Prince of Songkla University