Clinical trials: Post-operation Delirium
Surgical Site Infection, Dementia
Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial
Prophylactic TxA administration in patients undergoing major gastrointestinal surgery reduces the incidence of delirium after surgery when compared with placebo.
- Conditions
- Surgical Site Infection, Dementia, Cognition
- Trial name
- TRIGS-D (NCT05470816)
- Testing
- Tranexamic Acid 100Mg/ml Inj Vial 10ml
- Where
- Australia
- Volunteers
- 826 people
- Sponsor
- Bayside Health
Delirium, Post-operative Delirium
Nitric Oxide Levels Were Associated With Postoperative Delirium Following Cardiac Surgery
This study is a single-center prospective observational study conducted at the operating room, post-anesthesia care unit, and ICU of Tongji Hospital, from April 2023 to September 2024.
- Trial name
- NCT06748391
- Where
- China
- Volunteers
- 1,939 people
- Sponsor
- Tongji Hospital
Hypotension During Surgery
Controlled Hypotension in Rhinoplasty and Septoplasty: Incidence of Cognitive Dysfunction and Delirium
Controlled hypotension application is a commonly preferred anesthesia practice during surgical procedures, particularly in regions with rich tissue perfusion, aiming to reduce bleeding, enhance surgical field visibility, and…
- Trial name
- NCT06238973
- Testing
- Group Low, Group Middle
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hitit University
Delirium, Aged
Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients
The primary aim of this interventional study is to investigate the impact of perioperative administration of Maxigesic (combination of acetaminophen and ibuprofen) on delirium after minimally invasive lung surgery in elderly…
- Conditions
- Delirium, Aged, Lung Neoplasms, Robotic Surgical Procedures
- Trial name
- NCT05834569
- Testing
- Acetaminophen and Ibuprofen, Normal saline
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Korea University Guro Hospital
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Postoperative Pain, Delirium - Postoperative
Analgesia Methods and Early Mobilization in Geriatric ICU Patients After Major Surgery
This study looks at how different pain-control methods affect how quickly older adults get out of bed and start moving again after major surgery.
- Conditions
- Postoperative Pain, Delirium - Postoperative, Frailty, Postoperative Care in Geriatric Intensive Care Patients
- Trial name
- NCT07709975
- Testing
- Systemic Opioid Analgesia (± Multimodal), Epidural Analgesia, Peripheral Nerve Block (± Multimodal)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Postoperative Complications, Child
Effect of FPCA on Incidence of Emergency Delirium in Children After Surgery
Emergence delirium (ED) stands out as a prevalent postoperative complication among paediatric patients, correlating with extended hospitalization periods, escalated healthcare expenses, and increased incidence of postoperative…
- Conditions
- Postoperative Complications, Child, Family, Emergence Delirium
- Trial name
- NCT06092671
- Testing
- Family-centred perioperative care for anaesthesia
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Post-Operative Delirium, Hip Fracture
Post-operative Haloperidol Versus Placebo for Prevention of Post-operative Delirium After Acute Hip Surgery
In this study the investigators want to determine if treatment with haloperidol direct post-operatively after acute hip surgery in high risk patients protects against developing a post-operative delirium.
- Trial name
- NCT00250237
- Testing
- Haloperidol
- Where
- Netherlands
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Bronovo Hospital
Cognitive Decline, Heart Diseases
The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery.
Decline in cognitive function after surgery occurs most commonly in older patients and patients undergoing major surgeries, such as heart surgery.
- Conditions
- Cognitive Decline, Heart Diseases, Delirium
- Trial name
- NCT03324867
- Testing
- Regular insulin, Normal Saline Flush, 0.9% Injectable Solution
- Volunteers
- 316 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Delayed Emergence From Anesthesia, Delirium, Cause Unknown
Inadequate Emergence After Laparoscopic Surgery in Trendelemburg Position
The purpose of this study is to determinate if the patients submitted to laparoscopic surgery in trendelemburg position develope more inadequate anaesthesic emergence than patients submitted to laparoscopic surgery in other…
- Conditions
- Delayed Emergence From Anesthesia, Delirium, Cause Unknown, Confusion, Disorientation on Emergence
- Trial name
- NCT02101671
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Corporacion Parc Tauli
Postoperative Delirium
Shenfu Injection for Postoperative Delirium (SFI for POD)
Surgery or trauma may cause serious problem to patients, especially for senile ones, like postoperative delirium or more postoperative complications.
- Trial name
- POD (NCT05179252)
- Testing
- Shen-Fu injection, normal saline
- Volunteers
- 350 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Postoperative Delirium
Dexmedetomidine in Reducing Incidence of Emergence Agitation After Nasal Surgery
Various pharmacological interventions have been attempted previously to prevent postoperative EA with variable results. These include use of opioids, propofol, midazolam, ketamine, magnesium and alpha-2 agonists like clonidine…
- Trial name
- NCT05634148
- Testing
- Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 42 people
- Sponsor
- Security Forces Hospital
Post-operative Delirium, Major Non-cardiac Surgery
MIND After Surgery
Delirium is the most common neurological adverse outcome in elderly surgical patients. It is associated with an increased mortality and morbidity, including need for prolonged hospital stay and institutional care.
- Trial name
- MIND (NCT03785158)
- Testing
- Liquid Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- McMaster University
Nicotine Dependence
Prevention of Nicotine Abstinence in Critically Ill Patients After Major Surgery
The primary objective of this study is to determine whether the application of transdermal nicotine patches in critically ill patients after major surgery with nicotine abstinence condition is associated with a lower incidence of…
- Trial name
- NCT03847155
- Testing
- Nicotine patch
- Where
- Czechia
- Volunteers
- 52 people
- Sponsor
- University Hospital Ostrava
Hip Fractures
Intravenous Iron Supplement to Prevent Postoperative Delirium After Hip Fracture Surgery
This is a clinical trial to evaluate the effect of intravenous iron supplement with Ferinject (Ferric Carboxymaltose) in preventing postoperative delirium after hip fracture surgery.
- Trial name
- NCT05429749
- Testing
- Ferinject, Normal saline
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Seoul National University Bundang Hospital
C.Surgical Procedure; Cardiac, Delirium
Decreasing the Incidence of Delirium After Cardiac Surgery
In critically ill surgical patients, delirium (confusion and disorientation) is extremely common and is associated with longer hospital length of stay, mortality, cost, and long term cognitive impairment.
- Trial name
- NCT02119806
- Testing
- Benzodiazepine, Fentanyl, Propofol
- Where
- United States
- Sponsor
- University of California, Los Angeles
Postoperative Cognitive Dysfunction, Postoperative Delirium
Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction
The study comprised two primary components: a retrospective analysis of clinical big data and a conventional prospective cohort study involving patients undergoing cardiac surgery. The objectives were: 1.
- Trial name
- NCT06268249
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 7,065 people
- Sponsor
- Qin Zhang
Postoperative Delirium
Predictors for Postoperative Delirium After Major Noncardiac Surgery in Adults
This research project is an observational cohort study by retrospective chart review of patients that underwent major noncardiac surgery at University Hospital Basel, Switzerland, in the years 2011-2015.
- Trial name
- PODMAS (NCT04460716)
- Testing
- Major noncardiac surgery
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Emergence Agitation, Postoperative Pain
Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.
Sevoflurane is the agent of choice for induction and maintenance of day care anesthesia in children and has a wide acceptance among pediatric anesthesiologists.
- Trial name
- NCT03846284
- Testing
- Bupivacaine, Magnesium sulfate 50mg, Magnesium sulfate 30 mg
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Mansoura University
Acute Kidney Injury, Post-Operative Delirium
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that…
- Conditions
- Acute Kidney Injury, Post-Operative Delirium, Icu Delirium, Acute Renal Failure
- Trial name
- NCT00791648
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Vanderbilt University Medical Center