Clinical trials: Post-operation Delirium
Postoperative Delirium, Cardiac Disease
Multi-omics Analyses Reveal Microbiota-gut-brain Axis in ICU Patients With Post-cardiac Surgery Delirium
This case-control study is planned to recruit patients who meet the enrollment conditions, receive cardiac surgery (cardiac valve surgery or coronary artery bypass surgery) and cardiopulmonary bypass, and sign the informed…
- Conditions
- Postoperative Delirium, Cardiac Disease, Gastrointestinal Microbiome
- Trial name
- NCT05628480
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China National Center for Cardiovascular Diseases
Elderly, Orthopedic Surgery
Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after orthopedic surgery, dexmedetomidine supplemented intravenous…
- Conditions
- Elderly, Orthopedic Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03629262
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 712 people
- Sponsor
- Peking University First Hospital
Delirium
The Study of Post-operation Delirium and Prognosis of Cardiac Surgery Patients
Delirium is the most common neurological complication of cardiac surgery patients and associated with poor prognosis. In recent years, the important role of quantitative electroencephalogram (qEEG) in brain function monitoring is…
- Trial name
- NCT03351985
- Testing
- quantitative electroencephalogram (qEEG)
- Volunteers
- 56 people
- Sponsor
- Southeast University, China
Post-operative Delirium
Postoperative Delirium in Patients Undergoing Radical Cystectomy
In this study, post-operative delirium will be measured in patients undergoing surgery for bladder resection, and associated microRNA biomarkers will be evaluated in patients considered delirious and non-delirious after surgery.
- Trial name
- NCT03132168
- Testing
- Assessments, Blood Draw, Standardized Anesthetic Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Patients After Cardiac Surgery
Timing of Mobilization on Delirium in Patients After Cardiac Surgery
Early mobilization is recommended because it is effective in improving symptoms for patients after cardiac surgery. However, the optimal timing of mobilization for postoperative patients is not unclear.
- Trial name
- NCT06069349
- Testing
- Early Rehabilitation, usual treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jingyuan,Xu
Emergence Delirium, Post-Operative Cognitive Dysfunction
Post Operative Cognitive Dysfunction After Oncologic Surgery
Aim of this trial is to define if Post-Operative Cognitive Dysfunction, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, and Postoperative Delirium, relate to concentration of effector's…
- Trial name
- NCT03774420
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Padova
AKI - Acute Kidney Injury, Delirium, Postoperative
Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery
Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis.
- Trial name
- NCT06508593
- Testing
- Serum metabolic profile
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Cerebral Hypoxia, Postoperative Delirium
Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery
The aim of this study is to distinguish possible differences in frequency of delirium after Volatile Induction and Maintenance of Anesthesia and Total Intravenous Anesthesia in case of undeliberate cerebral desaturation during…
- Trial name
- NCT02133638
- Testing
- Sevoflurane, Propofol
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- Negovsky Reanimatology Research Institute
Delirium in Old Age, Anaesthetic
Impact of Propofol Versus Sevoflurane on Incidence of Postoperative Delirium in Elderly Patients After Spine Surgery
Postoperative delirium in older adults is a common and costly complication after surgery. Propofol and sevoflurane are commonly used anesthetics to maintain sedation during spine surgery, and have different sedative and…
- Trial name
- NCT05158998
- Testing
- propofol infusion, sevoflurane inhalation
- Where
- 2 sites in China
- Volunteers
- 298 people
- Sponsor
- Qianfoshan Hospital
Delirium, AAA
Abdominal Aortic Aneurysm Patients Remain at Risk for Delirium on the Surgical Ward After Intensive Care Unit Dismissal
The incidence of delirium following open abdominal aortic aneurysm (AAA) surgery is significant, with incidence rates ranging from 12 to 33%.
- Conditions
- Delirium, AAA, Intensive Care Unit Delirium, Surgery--Complications
- Trial name
- NCT04080557
- Testing
- Surgery
- Where
- Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Amphia Hospital
Delirium - Postoperative
Effect of Remimazolam Versus Dexmedetomidine on the Incidence of Delirium After Elective Cardiac Surgery with Cardiopulmonary Bypass: a Prospective Randomized Controlled Trial
The study aims to improve the post-open heart surgery lifestyle and overall experience, as well as assess the incidence of delirium using Remimazolam and Dexmedetomidine.
- Trial name
- NCT06756178
- Testing
- Propofol Group 1, Remimazolam Intervention, Dexmedetomidine Intervention
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Assiut University
Delirium
The Effect of Remifentanil Infusion During Emergence on the Incidence of Emergence Delirium
The aim of the present study is to assess the effect of postoperative remifentanil infusion on the incidence of emergence agitation in preschool-aged children undergoing strabismus surgery with sevoflurane anaesthesia.
- Trial name
- NCT02108795
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Yeungnam University College of Medicine
Postoperative Cognitive Dysfunction, Postoperative Delirium
Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium
Postoperative Cognitive Dysfunction(POCD) is commonly seen in cardiac surgery, which may lead to poor pognosis. Cerebral small vessel disease(CVSD) is refer as the main resource of delirium among elderly people.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Cerebral Small Vessel Diseases, Covert Postoperative Stroke
- Trial name
- NeuroIDEA (NCT05594966)
- Testing
- multimodal MRI
- Where
- China
- Volunteers
- 211 people
- Sponsor
- RenJi Hospital
General Anesthesia
The Relationship Between the SPI and the Postop ED
Surgical plethysmography index (SPI) is a device that can noninvasively monitor the balance between the nociception and ant-nociception using pulse photoplethysmographic amplitude (PPGA) and heart rate obtained through an oxygen…
- Trial name
- SPI_ED (NCT03328910)
- Testing
- SPI monitor (GE Healthcare, Helsinki, Finland)
- Where
- South Korea
- Sponsor
- Daegu Catholic University Medical Center
Surgery, Delirium
Feasibility and Acceptability of ReCognitionVR-based Cognitive Stimulation in Surgical Patients
This study aims to assess the feasibility, acceptability, and safety of using ReCognitionVR virtual reality-based software in older surgical patients.
- Conditions
- Surgery, Delirium, Delirium, Post-Operative
- Trial name
- NCT06232317
- Testing
- Virtual Reality Software, Traditional Orientation Methods
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
Postoperative Delirium
Intraoperative Dexmedetomidine Use, MMP-8, and Postoperative Delirium After Cardiac Surgery With Cardiopulmonary Bypass
This observational study evaluated the association between intraoperative dexmedetomidine use and postoperative delirium (POD) in adults undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Trial name
- NCT07759297
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 5,688 people
- Sponsor
- Shusheng Li
Delirium - Postoperative, Cardiac Surgery
Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients
Post-operative delirium is a common complication following cardiac surgery and is associated with increased 1 year mortality. Currently there are no drug therapies to prevent delirium.
- Conditions
- Delirium - Postoperative, Cardiac Surgery, Cardiac Surgery Subjects, Orexin Antagonist
- Trial name
- PROTEX (NCT06648681)
- Testing
- Lemborexant 5 mg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Post-Operative Delirium, Hip Fracture
Post-operative Haloperidol Versus Placebo for Prevention of Post-operative Delirium After Acute Hip Surgery
In this study the investigators want to determine if treatment with haloperidol direct post-operatively after acute hip surgery in high risk patients protects against developing a post-operative delirium.
- Trial name
- NCT00250237
- Testing
- Haloperidol
- Where
- Netherlands
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Bronovo Hospital
Emergence Agitation
Melatonin for Pediatric Emergence Agitation
efficacy of melatonin premedication on emergence agitation in children undergoing herniorrhaphy surgeries
- Trial name
- NCT05223010
- Testing
- Melatonin 5 MG/15 ML Oral Solution 0.05 mg/kg, Melatonin 5 MG/15 ML Oral Solution 0.2mg/kg, Melatonin 5 MG/15 ML Oral Solution 0.4mg/kg
- Where
- Egypt
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Bilateral Bispectral Index, Asymmetries and Post-operative Delirium
The primary objective of the study is to describe the value of interhemispheric asymmetry (ASYM), during the different intra- and peri-operative phases, in those patients who develop or do not develop post-operative delirium…
- Trial name
- DELBIS (NCT06761573)
- Testing
- Bilateral Bispetral Index Monitor will be applied on forehead of our patients, before surgery begins
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna