Clinical trials: Post-operation Delirium
Delirium, Postoperative Complications
Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium
Surgery is one of the major treatment methods for patients with malignant tumor. And, alone with ageing process, more and more elderly patients undergo surgery for malignant tumor.
- Conditions
- Delirium, Postoperative Complications, Postoperative Cognitive Dysfunction
- Trial name
- NCT02662257
- Testing
- Sevoflurane, Propofol
- Where
- 17 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
Delirium
Delirium and EuroSCORE II in Cardiac Surgery
The goal of this observational study is to find out the association between EuroSCORE II of Delirium in patients undergoing cardiac surgery.
- Trial name
- NCT05218720
- Testing
- EuroSCORE II risk score and CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Delirium, Cardiac Surgical Procedures
Dexmedetomidine Medication Records and Delirium After Coronary Artery Bypass Grafting
This retrospective observational study uses de-identified electronic health records from the TriNetX Global Collaborative Network. The procedure eligibility period is 1 January 2010 through 1 July 2025.
- Conditions
- Delirium, Cardiac Surgical Procedures, Coronary Artery Bypass Graft (CABG), Valve Surgery
- Trial name
- NCT07249164
- Testing
- Dexmedetomidine, No dexmedetomidine medication record in the specified window
- Where
- Taiwan
- Volunteers
- 343,112 people
- Sponsor
- China Medical University Hospital
Postoperative Delirium, Delirium Prevention
Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older Patients
Postoperative delirium is a common complication in older adults undergoing surgery. It is characterized by an acute and fluctuating disturbance of attention, awareness, and thinking.
- Conditions
- Postoperative Delirium, Delirium Prevention, Multicomponent Care Program, Older Adults (60 - 85 Years Old)
- Trial name
- EvaDel (NCT07787832)
- Testing
- Multicomponent delirium prevention program
- Volunteers
- 720 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Cognitive Dysfunction
n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery
Background: Delirium and long-term cognitive dysfunction (CD) are important complications of major surgery and intensive care treatment.
- Trial name
- NCT00757913
- Testing
- n-3 enriched nutrition
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiac Surgery, Cardiopulmonary Bypass
Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction
Age is no longer an absolute contraindication to cardiac surgery therefore there is often need for combined interventions (double valve repair/replacement, or coronary artery bypass graft and valve repair/replacement) with…
- Trial name
- CRIDD (NCT04062396)
- Testing
- Eurosets REMOWELL 2 oxygenator, LivaNova INSPIRE oxygenator
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Maria Cecilia Hospital
Post Operative Delirium, Cognitive Impairment
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU).
- Conditions
- Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
- Trial name
- tVNS (NCT07610655)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Emergence Delirium, Dexmeditomidine
Intravenous Dexmedetomidine for Emergence Delirium in Pediatric Patient
Various pharmacological interventions in peri-operative period have been used in literature to prevent ED which include use of propofol, fentanyl, ketamine, clonidine, midazolam and dexmedetomidine etc (5).
- Trial name
- NCT05813106
- Testing
- Dexmedetomidine Hydrochloride, normal saline
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Security Forces Hospital
Delirium, Emergence Delirium
EEG - Guided Anesthetic Care and Postoperative Delirium
The study is a prospective, double blinded, randomized and controlled parallel trial to investigate the effect of the anesthetic care guided by EEG monitor (SedLine) on postoperative delirium.
- Conditions
- Delirium, Emergence Delirium, Anesthesia, General, Electroencephalography
- Trial name
- EMODIPOD (NCT03330236)
- Testing
- Anesthetic "depth" management
- Where
- China
- Volunteers
- 1,560 people
- Sponsor
- Yale University
Delirium, Lumbar Radiculopathy
Shaping Anesthetic Techniques to Reduce Post-operative Delirium
The purpose of this study is to determine if light sedation with spinal anesthesia reduces the incidence of delirium compared to receiving general anesthesia during spinal surgery in older adults.
- Conditions
- Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
- Trial name
- SHARP (NCT03133845)
- Testing
- Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
Patients After Cardiac Surgery
Timing of Mobilization on Delirium in Patients After Cardiac Surgery
Early mobilization is recommended because it is effective in improving symptoms for patients after cardiac surgery. However, the optimal timing of mobilization for postoperative patients is not unclear.
- Trial name
- NCT06069349
- Testing
- Early Rehabilitation, usual treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jingyuan,Xu
Sleep, Atrial Fibrillation
Impact of Sleep Quality on Outcomes After Cardiac Surgery
Sleep is a basic human need and is essential for good quality of life, good health. In fact, humans spend one third of their life time in sleeping or attempting to do so.
- Conditions
- Sleep, Atrial Fibrillation, Delirium, Postoperative, Complications, Postoperative
- Trial name
- NCT06527105
- Testing
- Eye masks and ear plugs
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Delirium, Cardiac Disease
Reducing Delirium After Cardiac Surgery: A Multifaceted Approach Of Perioperative Care
The objective of this study is to reduce the incidence of postoperative delirium after cardiac surgery in the elderly patient. This proposal is a clinical trial designed to reduce delirium in patients undergoing cardiac surgery…
- Trial name
- NCT01378741
- Testing
- Propofol, Dexmedetomidine
- Where
- Canada
- Volunteers
- 185 people
- Sponsor
- University Health Network, Toronto
CABG
Effect of a Preoperative Video Education Program on ICU Delirium After CABG (VIDEO-CABG Trial)
The goal of this clinical trial is to evaluate the effect of a preoperative video-based educational program on postoperative outcomes in adult patients undergoing coronary artery bypass graft (CABG) surgery.
- Trial name
- VIDEO-CABG (NCT07570420)
- Testing
- Video-Based Educational Program
- Where
- Jordan
- Volunteers
- 220 people
- Sponsor
- University of Jordan
Delirium Symptoms
Role of REM Sleep Alterations in Post Operative Delirium After Cardiac Surgery
Acute confusional states known as delirium frequently occur in Intensive Care Units (ICU), mostly after cardiac surgery, leading to serious consequences.
- Trial name
- NCT02801318
- Testing
- Polysomnography
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Emergence Agitation, Emergence Delirium, Anesthesia
Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery.
This study is designed to evaluate the effectiveness of ultrasound-guided greater auricular nerve block (GAN) on the reduction of emergence agitation (EA) occurrence and EA severity in children who are receiving general…
- Conditions
- Emergence Agitation, Emergence Delirium, Anesthesia, Emergence From Anesthesia, Emergence Delirium
- Trial name
- NCT07435675
- Testing
- ultrasound-guided greater auricular nerve block (GANB)
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Postoperative Delirium (POD), Heart Rate Variability (HRV)
Heart Rate Variability Changes and Postoperative Delirium After Major Abdominal Surgery
This prospective observational cohort study aims to investigate whether early postoperative changes in heart rate variability (HRV) relative to baseline are associated with the development of postoperative delirium (POD) in older…
- Trial name
- HRVPOD (NCT07783464)
- Testing
- Perioperative Heart Rate Variability Changes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Emergence Agitation
Dexmedetomidine vs Propofol-lidocaine Mixture in Preventing the Post Operative Emergence Agitation Following Sevoflurane Anasthesia
Primary we will Compare the Efficacy between Dexmedetomidine and "Propofol-lidocaine" mixture in preventing the post operative emergence agitation following sevoflurane anasthesia in pediatric ophthalmic surgeries Secondary we…
- Trial name
- NCT07601698
- Testing
- Dexmedetomidine, Propofol
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Post-operative Delirium
EEG Guidance of Anesthesia (ENGAGES-CANADA)
This study examines the potential link between deep levels of anesthesia and delirium.
- Trial name
- ENGAGES (NCT02692300)
- Testing
- EEG-Guided Group
- Where
- Canada
- Volunteers
- 1,225 people
- Sponsor
- University of Manitoba
Postoperative Delirium, Postoperative Cognitive Dysfunction
Risk Factor of POD and POCD After Cardiac Surgery
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common after surgeries in the elderly, especially after cardiothoracic surgery.
- Trial name
- NCT03635229
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- Mahidol University