Clinical trials: Post-operative Cardiac Surgery
PONV, Blood Pressure
Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting
Intraoperative hypotension is associated with postoperative nausea and vomiting (PONV). Even though the exact mechanism linking PONV and hypotension is still unclear, a reduced intestinal tissue perfusion might trigger nausea and…
- Conditions
- PONV, Blood Pressure, Postoperative Recovery
- Trial name
- SICK (NCT05596695)
- Testing
- Minimizing blood pressure variability
- Where
- Austria
- Volunteers
- 272 people
- Sponsor
- Medical University of Vienna
Postoperative Complications
Biomarkers of Postoperative Complications After Cardiac Surgery
Postoperative delirium and other complications are important adverse outcomes following cardiac surgery. This study will integrate perioperative clinical information with molecular measurements to investigate factors associated…
- Trial name
- NCT07900009
- Testing
- no intervention
- Volunteers
- 300 people
- Sponsor
- Rao Sun
Hyperalgesia, Pain, Postoperative
Effects of Nefopam on Hyperalgesia After Cardiac Surgery
Postoperative pain after major surgery is consecutive not only to the nociceptive inputs coming from the surgical lesion, but also to peripheral and central neuronal sensitization.
- Conditions
- Hyperalgesia, Pain, Postoperative, Pain, Chronic Disease
- Trial name
- NefalCard (NCT00413257)
- Testing
- Nefopam, néfopam
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Vasoplegic Syndrome of Cardiac Surgery
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac…
- Trial name
- INVASC (NCT06934798)
- Testing
- Vasopressin intravenous infusion, Norepinephrine intravenous infusion
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Delirium
Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
The purpose of this chart review study is to determine whether the use of dexmedetomidine, a selective α2-adrenergic receptor agonist with sedative, analgesic, and antinociceptive properties, would be associated with a lower…
- Trial name
- NCT00417664
- Testing
- Dexmedetomidine, Propofol, Midazolam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Transfusion Requirements in Cardiac Surgery III
TRICS-III is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in high risk patients having cardiac surgery using a non-inferiority trial design.
- Trial name
- TRICS-III (NCT02042898)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 74 sites in United States, Australia and 17 more
- Volunteers
- 5,028 people
- Sponsor
- Unity Health Toronto
Heart Attack, Cardiac Arrest
Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys
Based on limited published epidemiological data, up to an alarming 1 in 50 surgical inpatients die within 30 postoperative days.
- Conditions
- Heart Attack, Cardiac Arrest, Congestive Heart Failure, Atrial Fibrillation
- Trial name
- SATISFY-SOS (NCT02032030)
- Where
- United States
- Volunteers
- 73,952 people
- Sponsor
- Washington University School of Medicine
Thoracic Surgery
Electrical Impedance Tomography in Evaluating the Effects of Noninvasive Ventilation in Post-Operative Cardiac Surgery
NTRODUCTION: cardiac surgery can lead to pulmonary complications such as hypoxemia and atelectasis. Noninvasive ventilation has been used to prevent and treat such complications.
- Trial name
- NCT03371628
- Testing
- Non invasive ventilation
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Postoperative Pain
Efficacy of Erector Spinae Plane Block Analgesia After Off Pump Cardiac Surgery
In this study the investigators will investigate the efficacy of ESPB as a part of Enhanced recovery after surgery on postoperative analgesia and recovery criteria after off pump cardiac surgery.
- Trial name
- ESPB (NCT05769309)
- Testing
- Erector spinae block, Fentanyl
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Menoufia University
Cardiac Surgery
The Efficacy of Early Postoperative Enteral Immunonutrition in Low-Risk Cardiac Surgery Patients
The aim of this study is to investigate the efficacy of early postoperative enteral immunonutrition on immune response and outcomes in the low operative risk cardiac surgery population with low phase angle value measured by the…
- Trial name
- NCT04047095
- Testing
- Immunonutrients + normal daily meal, Normal daily meal
- Where
- Lithuania
- Volunteers
- 55 people
- Sponsor
- Vilnius University
Postoperative Acute Kidney Injury
Correlation Between Monitoring Renal Hemodynamics by Esophageal Ultrasound and Acute Kidney Injury After Heart Surgery
Acute kidney injury (AKI) is a common complication of cardiac surgery, which seriously affects the postoperative complication rate and mortality of patients.Acute kidney injury occurs in 5-30% of patients after cardiac surgery…
- Trial name
- NCT03798067
- Volunteers
- 60 people
- Sponsor
- Xuzhou Medical University
Cardiac Disease, Myocardial Dysfunction
Temporary Epicardial Pace Wire With Integrated Sensor for Continuous Postoperative Monitoring of Myocardial Function
Transesophageal echocardiography is used to monitor cardiac wall motion at various time points during open-heart surgery. After surgery, the measurements are made at various time points by transthoracic echocardiography.
- Trial name
- NCT04886934
- Testing
- CS1 System
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Cardiaccs AS
Pain, Postoperative
Serratus Planus Block After Minimally Invasive Cardiac Surgery
Many patients receiving MICS (minimally invasive cardiac surgery) suffer from significant postsurgical pain. While systemic analgesic therapy has been proven to be insufficient in a great number of patients, significant unwanted…
- Trial name
- NCT06746272
- Testing
- Serratus Anterior Plane Block
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Type 2, Hyperglycemia
Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control
Hypothesis: In surgical patients with type 2 diabetes, taking either metformin or salsalate on the morning of surgery will reduce the incidence of hyperglycemia, inflammation and even surgical site infections, without any obvious…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Perioperative/Postoperative Complications, Salsalate to Improve Non-cardiac Surgery Glucose Control
- Trial name
- OPTIM(i)SING (NCT03816488)
- Testing
- Metformin, Salsalate
- Sponsor
- McMaster University
Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery
PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery
This prospective observational study aims to evaluate whether intraoperative venous-to-arterial carbon dioxide partial pressure difference (PCO₂ gap) and arterial lactate levels can serve as early predictors of postoperative…
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07843186
- Volunteers
- 185 people
- Sponsor
- Ain Shams University
Opioid Use
Music Therapy for Post-cardiac Surgery Pain Management
Music therapy as a supplement to post surgery pain management in cardiac surgery patients following median sternotomy.
- Trial name
- NCT05098561
- Testing
- Music Treatment
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Postoperative Pulmonary Atelectasis, Negative Pressure Therapy
Evaluation of the Effect of Novel Recruitment Maneuver Therapy for Postoperative Pulmonary Atelectasis
1. Oxygenation index and bedside ultrasound would be used to evaluate the therapeutic effect of novel recruitment maneuver therapy in the patients with pulmonary atelectasis after cardiac surgery. 2.
- Trial name
- NCT06049173
- Testing
- Negative extra-abdominal pressure (NEXAP)-based lung recruitment maneuver, stepwise positive end-expiratory pressure (PEEP)-based lung recruitment maneuver
- Where
- China
- Volunteers
- 77 people
- Sponsor
- Jilai Xiao
Coronary Artery Disease, Postoperative Pulmonary Complications
Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function
Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation.
- Conditions
- Coronary Artery Disease, Postoperative Pulmonary Complications, Pulmonary Atelectasis, Postoperative, Diaphragm Dysfunction
- Trial name
- FCV-PCV-DTI-LU (NCT07800741)
- Testing
- Flow-Controlled Ventilation, Pressure-Controlled Ventilation (PCV)
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Pain, Acute Post-Operative, Anxiety
Effects of Reflexology and Cold Application Before Chest Tube Removal in CABG Patients
This randomized controlled trial evaluated the effects of foot reflexology and cold application, administered separately before chest tube removal, on pain, state anxiety, and physiological parameters in patients following…
- Conditions
- Pain, Acute Post-Operative, Anxiety, Chest Tube Removal, Coronary Artery Bypass
- Trial name
- NCT07528482
- Testing
- Reflexology, Cryotherapy alone
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ankara University
Hypertension, Pulmonary, Hemolysis
Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion
The objective of this study is to assess if prolonged storage time of a packed red blood cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible population such as cardiac surgery patients.
- Trial name
- NCT02217683
- Testing
- Nitric Oxide
- Where
- United States
- Sponsor
- Massachusetts General Hospital
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