Clinical trials: Post-operative Cardiac Surgery
Postoperative Delirium
Risk Factors for Postoperative Delirium in Elderly Patients Undergoing Major Non-Cardiac Surgery in Singapore
The primary aim is to establish the risk factors, in particular the modifiable risk factors, for the development of POD in elderly patients undergoing major non-cardiac surgery in a tertiary hospital in Singapore.
- Trial name
- NCT04617210
- Testing
- Neurocognitive tests and blood taking
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Cardiac Surgery, Postoperative Pain
Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Cardiac Surgery
This prospective, randomized, controlled study aims to evaluate the effects of ultrasound-guided bilateral single-shot serratus posterior superior intercostal plane (SPSIP) block on postoperative recovery and pain management in…
- Conditions
- Cardiac Surgery, Postoperative Pain, Postoperative Recovery After Cardiac Surgery
- Trial name
- NCT07785323
- Testing
- Serratus posterior superior intercostal plane block, Standard Perioperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Burak Çilingir
Carcinoma, Non-Small-Cell Lung, Pain, Postoperative
Why in Hospital After VATS Lobectomy
The study aims to identify specific or potential reasons that prolong the length of hospital stay after video-assisted thoracoscopic surgery lobectomy.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Pain, Postoperative, Postoperative Nausea and Vomiting, Infection
- Trial name
- NCT04294108
- Testing
- Prolong in-hospital stay
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Delirium
Key circRNA Identification of Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery
The observational study aims to discover differentially expressed circRNAs in the peripheral blood of patients with postoperative delirium, which aims to answer the main questions at: Whether there are changes in circRNA…
- Trial name
- NCT05743660
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuzhou Central Hospital
Open Heart Surgery
Benefit of Peri-operative Bilateral ESP Catheters for Enhanced Recovery for Cardiac Surgery (ERCS)
To demonstrate if the addition of peri-operative regional analgesia by Bilateral ESP catheters improves the enhanced recovery program after open heart surgeries for the duration of hospitalisation, quality of analgesia…
- Trial name
- ESP_ERCS (NCT04506762)
- Testing
- Regional analgesia
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- Vinmec Healthcare System
Hyperoxia, Normoxic
Intraoperative Oxygen Concentration and Neurocognition After Cardiac Surgery
This is a randomized, prospective controlled trial in patients undergoing cardiac surgery, specifically on-pump coronary artery bypass grafting, comparing level of administered oxygen and partial pressure of arterial oxygen in…
- Conditions
- Hyperoxia, Normoxic, Delirium
- Trial name
- NCT02591589
- Testing
- Normoxic oxygenation, Hyperoxic oxygenation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Chylothorax, Congenital Heart Disease
Propranolol Treatment for Postoperative Chylothorax
Postoperative chylothorax is a serious complication after open heart surgery for pediatric patients with congenital heart disease (CHD).
- Conditions
- Postoperative Chylothorax, Congenital Heart Disease, Open Heart Surgery, Chylothorax
- Trial name
- NCT06833320
- Testing
- Propranolol Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- June Wu
Post Operative Atrial Fibrillation
Prevention of Post-OP AFib Using Combination of CardiaMend and Amiodarone
The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing isolated cardiac arterial bypass…
- Trial name
- CAMP POAF (NCT05681182)
- Testing
- CardiaMend with the Addition of Amiodarone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- WakeMed Health and Hospitals
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Circulatory Failure / Shock State, Fluid Therapy
Metabolic Fluid Responsiveness in Children
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery.
- Trial name
- METAFRIC (NCT07255469)
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bordeaux
General Surgery, Perioperative Medicine
Preoperative Walking Evaluation and Postoperative Outcome
The hypothesis is that physical activity is associated with a reduced risk of complications and death after surgery. Self-reporting of physical activity is prone to be unreliable.
- Trial name
- PREVENT (NCT06023069)
- Testing
- Number of steps recorded by mobile phone as a proxy for physical activity
- Where
- Sweden
- Volunteers
- 264 people
- Sponsor
- Karolinska Institutet
Surgical Site Infection
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections…
- Trial name
- CALIPSO (NCT05447559)
- Testing
- Cefazolin, Water for injection
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 9,180 people
- Sponsor
- Monash University
Vasoplegic Shock, Cardiopulmonary Bypass
Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia.
- Conditions
- Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia
- Trial name
- ANGII_V (NCT07671365)
- Testing
- Angiotensin II (Giapreza®)
- Volunteers
- 329 people
- Sponsor
- Methodist Healthcare System of San Antonio
Circulatory Shock, Non-cardiac Surgery
Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery
The purpose of the present study is to evaluate the effect of vasopressin compared to norepinephrine on the clinical complications of patients with vasospastic shock after noncardiac surgeries.
- Trial name
- VANCSIII (NCT03483753)
- Testing
- Vasopressin, Norepinephrine
- Sponsor
- University of Sao Paulo
Postoperative Hypothermia in Patients With Cardiopulmonary Bypass
Incidence and Risk Factors of Postoperative Hypothermia in Cardiac Surgery
Background: Postoperative hypothermia may result in relevant complications such as adverse cardiovascular events, wound infection, and coagulopathy with consecutive blood loss.
- Trial name
- NCT02244034
- Testing
- hypothermia
- Where
- Thailand
- Volunteers
- 760 people
- Sponsor
- Mahidol University
Postoperative Pain, Coronary Artery Bypass Grafting (CABG) Surgery
Intertransverse Process Block for Postoperative Acute Pain After Coronary Bypass Surgery
This prospective, randomized controlled trial aims to evaluate the effect of bilateral intertransverse process block (ITPB) on acute postoperative pain in patients undergoing coronary artery bypass grafting (CABG) via median…
- Conditions
- Postoperative Pain, Coronary Artery Bypass Grafting (CABG) Surgery, Sternotomy
- Trial name
- NCT06908681
- Testing
- Bilateral Intertransverse Process Block (ITPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Mustafa Aydemir
Shock, Septic, Hyperlactatemia
Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
The MostCare system, thanks to the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy), provides new hemodynamic parameters of the cardiovascular system.
- Conditions
- Shock, Septic, Hyperlactatemia, Oliguria, Aortic Aneurysm, Abdominal
- Trial name
- RELASTANCE (NCT04388267)
- Testing
- Fluid challenge
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France
Pain
Requirement of Analgesics After Two Remifentanil Dosing Regimen in Cardiac Surgery.
Prospective double blind study comparing two remifentanil dosing protocols (0.1 and 0.3 mcg/kg/min) during cardiac surgery. Main outcome measures are postoperative opioid requirements (PCA oxycodone) and postoperative pain (VAS…
- Trial name
- REMISYD (NCT00757198)
- Testing
- remifentanil
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Kuopio University Hospital
Hypoxia
Efficacy and Safety of Using Noninvasive Ventilation Associated With Recruitment Maneuver in Cardiac Surgery.
Cardiac surgery can evolve with complications in the postoperative period, atelectasis and hypoxemia are the major pulmonary dysfunctions.
- Trial name
- NCT02913391
- Testing
- recruitment group (RG), control group (CG)
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Mieko Cláudia Miura
Acute Kidney Injury, Coronary Artery Disease
Renal Doppler Indices for Predicting Acute Kidney Injury After Isolated CABG
Acute kidney injury can occur after coronary artery bypass grafting (CABG). This prospective, single-center observational study will evaluate whether two measurements obtained from renal Doppler ultrasound-the renal augmented…
- Trial name
- NCT07821983
- Testing
- Renal Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
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