Clinical trials: Post-operative Cardiac Surgery
Minimally Invasive Cardiac Surgery
Postoperative Respiratory Complications According to Neuromuscular Block Reversal After MICS
Postoperative respiratory complications according to the type of drug (sugammadex, pyridostigmine) used for reversible neuromuscular block when extubating an endotracheal tube in the operating room after minimally invasive…
- Trial name
- NCT04957836
- Testing
- reversal with sugammadex
- Where
- South Korea
- Volunteers
- 1,216 people
- Sponsor
- Pusan National University Yangsan Hospital
Postoperative Delirium (POD)
The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery
Postoperative delirium after cardiac surgery is an acute cerebral dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances.
- Trial name
- Delirium (NCT06901479)
- Testing
- Blood was drawn for proteomics testing and Magnetic Resonance Imaging.
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Postoperative Bloodloss
Minimal Extracorporeal Circuits (MECC) in Cardiac Surgery Procedures
The standard heart-lung machine is a major trigger of systemic inflammatory reactions, hemodilution, coagulopathy or organ failure.
- Trial name
- MECC (NCT01306903)
- Testing
- MECC, MOPS, Super MOPS
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Patient Blood Management, Cardiac Surgery
Study on the Relationship of Arterial-venous Oxygen Difference and Postoperative Complications After Cardiac Surgery.
Avoidance of unnecessary blood transfusions has always been a focus of clinical research. The rate of perioperative red blood cell transfusion in patients undergoing cardiac surgery under cardiopulmonary bypass reaches between…
- Conditions
- Patient Blood Management, Cardiac Surgery, Transfusion
- Trial name
- NCT05078086
- Testing
- No intervention
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Heart Insufficiency
EVENT - Evaluation of the Influence of hTEE
Compromised tissue oxygenation during surgery may negatively influence patient outcome. Primary cause of insufficient tissue oxygenation is reduced cardiac output due to hypovolemia and/or reduced cardiac contractility.
- Trial name
- EVENT (NCT02046954)
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Charite University, Berlin, Germany
Heart; Surgery, Heart, Functional Disturbance as Result
The Use of Cooling Helmet for Neuroprotection Management in Open Heart Surgery
To know the relationship between the use of cooling helmet with the changes of NSE level and postoperative delirium event in open heart surgery
- Trial name
- NCT05264766
- Testing
- Cooling helmet on, Cooling helmet off
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Universitas Indonesia
Pericardial Effusion, Inflammatory Response After Surgery
Anesthesia Management, Inflammatory Response and Recovery After Non-intubated VATS Pericardial Window
Non-intubated video-assisted thoracoscopic surgery (NIVATS) is performed under spontaneous ventilation and avoids tracheal intubation and one-lung mechanical ventilation.
- Conditions
- Pericardial Effusion, Inflammatory Response After Surgery, Postoperative Complications, Procedural Sedation and Analgesia
- Trial name
- RNIVATS (NCT07800767)
- Testing
- Systemic opioid-based analgesia during NIVATS, Thoracic regional analgesia during NIVATS
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Cardiac Surgery, Mechanical Power
Individualized PEEP and Pulmonary Complications in On-Pump CABG
Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgery, Mechanical Power, Postoperative Pulmonary Complications (PPCs)
- Trial name
- NCT07623109
- Testing
- Driving pressure-based personalized PEEP strategy, Conventional lung protective mechanical ventilation strategy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Respiratory Complication, Respiration, Artificial
Ventilation in Cardiac Surgery
The purpose of this study is to evaluate prospectively ventilatory practices in the perioperative cardiac surgery period.
- Conditions
- Respiratory Complication, Respiration, Artificial, Anesthesia, General, Bypass, Cardiopulmonary
- Trial name
- VENICE (NCT03255356)
- Testing
- Survey
- Where
- 10 sites in Belgium, Brazil and 8 more
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Chronic Postoperative Pain
PANDORA: Paravertebral AdjuNctive DexamethasOne Palmitate Reducing Chronic Pain After Caridiac Surgery
The goal of this single-center, prospective, double-blind randomized controlled clinical trial is to explore preventive interventions for chronic postoperative pain (CPSP) in patients undergoing minimally invasive cardiac…
- Trial name
- NCT05920967
- Testing
- Dexamethasone Palmitate, Dexamethasone Sodium Phosphate
- Where
- China
- Volunteers
- 562 people
- Sponsor
- Xijing Hospital
Systemic Inflammatory Response Syndrome, Cardiac Diseases
Dexamethasone for Cardiac Surgery Trial
This is a multicenter, randomized, double-blind trial, comparing clinical outcomes after the administration of high-dose dexamethasone versus placebo in patients undergoing heart surgery with the use of cardiopulmonary bypass.
- Conditions
- Systemic Inflammatory Response Syndrome, Cardiac Diseases, Postoperative Complications
- Trial name
- NCT00293592
- Testing
- Dexamethasone
- Where
- Netherlands
- Volunteers
- 4,500 people
- Sponsor
- UMC Utrecht
Cardiac Surgery, Elderly Patient
Preoperative Nutritional Status Scores to Predict PPC in Elderly With Cardiac Surgery
This prospective study investigates prognostic values and compares the role of nutritional status by using GNRI, MNA-SF, PNI, and NAF in predicting post-operative pulmonary complication among elderly patients with cardiac surgery.
- Conditions
- Cardiac Surgery, Elderly Patient, Postoperative Pulmonary Complication, Nutrition Scoring System
- Trial name
- NCT06340464
- Testing
- Nutrition scoring systems
- Where
- Thailand
- Volunteers
- 217 people
- Sponsor
- Prince of Songkla University
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Atrial Fibrillation, Cardiac Tamponade
Posterior Pericardiotomy for Prevention of POAF After Cardiac Surgery: RCT in Yemen
A single-center, randomized controlled trial in Yemen evaluating whether posterior pericardiotomy (PP) reduces postoperative atrial fibrillation (POAF) after open-heart surgery.
- Trial name
- PP-POAF (NCT07266935)
- Testing
- Posterior Pericardiotomy, Standard Care
- Where
- Yemen
- Volunteers
- 210 people
- Sponsor
- Taiz University - Faculty of Medicine
Surgical Site Infection, Sternal Infection
D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery
Prospective, Multinational, Multicenter, Randomized, Parallel Controlled, Two arms, Single Blind, Study to Assess the Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SOC) IV Prophylactic…
- Conditions
- Surgical Site Infection, Sternal Infection, Cardiac Surgery
- Trial name
- NCT03558984
- Testing
- D-PLEX, Standard of Care
- Where
- 3 sites in United States, Israel
- Volunteers
- 2 people
- Sponsor
- PolyPid Ltd.
Undergo Elective Cardiac Surgery, Cardiopulmonary Bypass
Evaluation of the Effectiveness of Ultrasound-Guided Stellate Ganglion Block in Cardiac Surgery Anesthesia on Postoperative Recovery
Heart surgery is a complex and delicate procedure that affects more than one million people worldwide each year. Patients who undergo this surgery are generally elderly and have multiple comorbidities, which places them in…
- Conditions
- Undergo Elective Cardiac Surgery, Cardiopulmonary Bypass, CPB
- Trial name
- ECLAIR (NCT07676487)
- Testing
- Elective surgery (≥ 24 hours) with cardiopulmonary bypass (more than 2 procedures)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Bypass Complication, Respiratory Complication
Aortic Cross Clamping Time, and Postoperative Respiratory Function
Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.
- Trial name
- NCT03072784
- Testing
- aortic cross clamping
- Where
- Egypt
- Volunteers
- 53 people
- Sponsor
- Assiut University
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré
Surgery, Cardiac, Atrial Fibrillation
Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Postoperative atrial fibrillation is quite common after cardiac surgery with up to 1 in 3 patients experiencing this abnormal heart rhythm.
- Trial name
- PATRONUS (NCT05543278)
- Testing
- Amiodarone
- Volunteers
- 242 people
- Sponsor
- Massachusetts General Hospital
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