Clinical trials: Post-operative Cardiac Surgery
Coronary Artery Disease, Postoperative Pain
Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery
The purpose of this study is to determine if ultrasound-guided bilateral pectointercostal fascial plane blocks with bilateral rectus sheath blocks block decrease pain scores, decrease opioid consumption, improve respiratory…
- Conditions
- Coronary Artery Disease, Postoperative Pain, Respiratory Failure
- Trial name
- NCT04908449
- Testing
- Rectus sheath block with bupivacaine
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical College of Wisconsin
Surgical Wound Infection
Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection
1. Infection control and health-care-associated infections and Safety of medical service providers 2. Evidence based management of common medical and surgical problems
- Trial name
- NCT05276687
- Testing
- Betadine, Vancomycin
- Volunteers
- 80 people
- Sponsor
- Assiut University
Infection, Surgical Site
Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial
The goal of this pragmatic, multi-centre factorial cluster randomized cross-over trial is to assess the efficacy of a combination of cefazolin plus vancomycin compared to cefazolin monotherapy, as well as a comparison of short…
- Trial name
- PICS (NCT06567808)
- Testing
- Cefazolin, Vancomycin
- Volunteers
- 38,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiac Surgery, Mechanical Ventilation After Surgery
Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients
Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure…
- Trial name
- NCT07189026
- Testing
- Airway opening pressure
- Where
- Canada
- Volunteers
- 196 people
- Sponsor
- Laval University
Post Cardiac Surgery Atrial Fibrillation
The Outcomes of Sympathetic Cardiac Denervation on Postoperative Atrial Fibrillation After Cardiac Surgery, Randomized Controlled Trial
we compare the effect of cutting heart nerves in one group of patients with open heart surgery and other group without cutting oh development of disturbance of heart beat after surgery
- Trial name
- NCT07811817
- Testing
- cardiac sympathetic denervation, Standard open-heart surgery without additional epicardial or fat pad dissection.
- Where
- Egypt
- Volunteers
- 560 people
- Sponsor
- Zagazig University
Acute Kidney Injury
Application of CLCVP Technique in Early Intervention of CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05855954
- Testing
- controlled low central venous pressure technique (CLCVP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Pain, Postoperative
Effects of TTPB vs PIFB on Opioid Consumption in Patients After Cardiac Surgery.
The objective of this study is to compare the effects of TTPB vs PIFB on postoperative opioid consumption in patients undergoing open cardiac surgery.
- Trial name
- NCT05627869
- Testing
- Transversus thoracic plane block, Pecto intercostal fascial block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Beni-Suef University
Acute Kidney Injury
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial…
- Trial name
- NCT07718373
- Testing
- L-arginine
- Volunteers
- 5,000 people
- Sponsor
- Xijing Hospital
Postoperative Wound Infection Superficial Incisional, Postoperative Wound Infection Deep Incisional Surgical Site
Safety and Efficacy of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery.
This study is aimed to assess the anti-infective efficacy of D-PLEX over a period of 3 months post operation as well as the safety over a period of 6 months, by preventing sternal infection post cardiac surgery in patients above…
- Trial name
- NCT02731573
- Testing
- D-PLEX, Open heart surgery
- Where
- 5 sites in Israel
- Volunteers
- 81 people
- Sponsor
- PolyPid Ltd.
Systemic Inflammatory Response Syndrome, Postoperative Shock
The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery
In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic…
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Shock, Coronary Artery Disease, Extracorporeal Circulation; Complications
- Trial name
- REMEDI (NCT03939273)
- Testing
- Vancomycin Oral, Metronidazole Oral, Ciprofloxacin Pill
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Pain, Postoperative, Respiratory Complication
Thoracic Epidural Analgesia and Bilateral Erector Spinae Plane Block on Postoperative Pain in Open Heart Surgeries
Postoperative pain negatively effects respiratory functions in open heart surgeries. The aim of the study is to compare the effects of thoracic epidural analgesia (TEA) and erector spinae plane block (ESPB) on postoperative pain…
- Trial name
- NCT06098859
- Testing
- Thoracic epidural analgesia, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Chest CT With Iterative Reconstruction as an Alternative to Conventional Chest X-ray Prior to Heart Surgery
To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared to…
- Conditions
- Cardiac Defects, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Stroke
- Trial name
- CRICKET (NCT02173470)
- Testing
- CT scan
- Where
- 3 sites in Hungary, Netherlands
- Volunteers
- 866 people
- Sponsor
- UMC Utrecht
Feasibility of a Meditation Program Perioperatively
Guided Meditation as an Adjunct to Enhance Postoperative Recovery
The primary purpose of this trial is to test the feasibility of implementing a meditation program in the perioperative period.
- Trial name
- NCT03198039
- Testing
- Meditation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Recovery, Length of Hospital Stay
The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery
Anticholinergic drugs are common in older adults and linked to cognitive decline, frailty, longer hospital stay, and higher mortality.
- Conditions
- Postoperative Recovery, Length of Hospital Stay, Postoperative Complications
- Trial name
- NCT06349057
- Testing
- reducing anticholinergic burden
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
HEART RATE
Intraoperative Heart Rate Thresholds and Postoperative Mortality
This retrospective observational study investigates the association between intraoperative heart rate and 30-day postoperative mortality among patients undergoing non-cardiac surgery.
- Trial name
- NCT07075744
- Testing
- Intraoperative Heart Rate Monitoring
- Where
- South Korea
- Volunteers
- 139,149 people
- Sponsor
- Asan Medical Center
Periodontitis, Heart Valve Disease
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery
This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.
- Conditions
- Periodontitis, Heart Valve Disease, Postoperative Infection, Cardiovascular Disease
- Trial name
- Perio-CVS (NCT07626801)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
Atrial Fibrillation, Atrial Flutter
Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery
Atrial Fibrillation (AF) is a common postoperative complication of cardiac surgery, occuring in approximately 25-30% of coronary artery bypass graft (CABG) patients and 35-40% of heart valve repair/replacement patients.
- Trial name
- NCT00953212
- Testing
- beta blockers, amiodarone, ascorbic acid
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- MaineHealth
Acute Kidney Injury After Adult Cardiac Surgery
The Effect of High Single Dose of Dexamethasone in Prevention of Post-operative Acute Kidney Injury in Cardiac Surgeries Requiring Cardiopulmonary Bypass
The aim of the current study is to assess the effect of intra operative single high dose dexamethasone (1 mg/kg) in decreasing the incidence of post-operative acute kidney injury after cardiac surgeries with cardiopulmonary bypass
- Trial name
- NCT06783634
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
oPAP Should be > 25mmHg in Right Heart Catheterization at Rest, There Should be Patients Who Will Undergo Non-cardiac and Non-obstetric Surgery
Postoperative Morbidity / Mortality Rates of Patients With Pulmonary Hypertension
Pulmonary hypertension (PHT) is an oPAP ≥25 mmHg as assessed by right heart catheterization at rest. It is divided into 5 groups according to its etiology and mechanism.
- Trial name
- PulmonaryHT (NCT05565911)
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Baskent University
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