Clinical trials: Post-operative Cognitive Dysfunction
Delirium and Post-operative Cognitive Dysfunction (POCD)
Cognitive Outcome After Two-stage Liver-Operation
Cognitive outcome (delirium and post-operative cognitive deficiency) in patients undergoing two-time liver resection.
- Trial name
- 2-StaLi (NCT01809782)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Neuroinflammation in Cognitive Decline Post-cardiac Surgery
Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing.
- Conditions
- Postoperative Cognitive Dysfunction, Coronary Artery Disease, Pathophysiology
- Trial name
- FOCUS (NCT04520802)
- Testing
- 18F-DPA-714 PET/CT neuroimaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Anesthesia, Spinal, Elderly
Influence Of Low Dose Intrathecal Naloxone On Bupivacaine - Fentanyl Spinal Anaesthesia For Lower Limb Orthopedic Surgery In Elderly Patients
Fentanyl is a safer alternative than morphine in the management of postoperative pain in elderly. However, pruritus, nausea and vomiting are unwanted side effects of intrathecal fentanyl administration, that can decrease patient…
- Trial name
- NCT04673812
- Testing
- Bupivacaine-fentanyl
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Kasr El Aini Hospital
Elective Surgery, Postoperative Cognitive Dysfunction
Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty
Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2.
- Conditions
- Elective Surgery, Postoperative Cognitive Dysfunction, Knee Arthroplasty
- Trial name
- NCT04225702
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
Frail Elderly Syndrome, Postoperative Delirium
Different Frailty Scores to Incidence of Post-operative Delirium and Cognitive Dysfunction
Patients who are frail will have higher rate for post-operative morbidities, mortality, prolonged hospital stays, loss of independence, increase in institutionalization, post-operative cognitive dysfunction (POCD) and delirium…
- Conditions
- Frail Elderly Syndrome, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT04056871
- Testing
- Frailty Screening Tools
- Where
- Malaysia
- Volunteers
- 400 people
- Sponsor
- University of Malaya
Postoperative Delirium, PD
Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00561678
- Testing
- Precedex (Dexmedetomidine)
- Where
- 10 sites in United States
- Volunteers
- 404 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Cognitive Dysfunction
Implementation of a Cognitive Training Program to Reduce the Risk of Postoperative Cognitive Dysfunction
Background: The postoperative cognitive dysfunction (POCD) is a frequent complication, often underestimated and leads to a negative impact on the quality of life for patients and their families.
- Trial name
- NCT03620968
- Testing
- cognitive training
- Where
- Spain
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Centro Medico Teknon
Delirium, Postoperative Cognitive Deficit (POCD)
Neuroprotection With Dexmedetomidine in Patients Undergoing Elective Cardiac or Abdominal Surgery (Neuprodex)
The drug Dexmedetomidine will be investigated in 72 patients (men and women) undergoing elective cardiac or abdominal surgery. The study medication will be administered perioperatively by intravenous infusion continuously (at the…
- Trial name
- NCT02096068
- Testing
- Dexmedetomidine (Dexdor®), 0.9% Sodium Chloride
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Claudia Spies
Post-Operative Confusion, Long Term Adverse Effects
Depth of Anaesthesia and Long-term Survival: The Balanced Anaesthesia Follow-up Study
Anaesthetic depth and complications after major surgery: an international, randomised controlled trial - The BALANCED trial. In this large, international, randomised controlled trial that enrolled patients aged 60 years and over…
- Conditions
- Post-Operative Confusion, Long Term Adverse Effects, Surgery--Complications, Cognitive Dysfunction, Postoperative
- Trial name
- BALANCEDLT (NCT04965324)
- Testing
- Anaesthesia Depth
- Where
- New Zealand
- Volunteers
- 6,644 people
- Sponsor
- Auckland City Hospital
Anesthesia, Postoperative Pain
Opioid-free Anesthesia and Acute Postoperative Pain
Control of intraoperative and postoperative pain with the use of opioids constitutes normal practice. Opioid free anesthesia (OFA) is a relatively recent anesthesiology practice according to which opioids are not administered…
- Conditions
- Anesthesia, Postoperative Pain, Cognitive Impairment, Variable
- Trial name
- NCT04976842
- Testing
- OFA, OBA
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Impact of Repetitive Transcranial Magnetic Stimulation on the Prognosis of Elderly Surgical Patients
Exploring the effects of repeated transcranial magnetic stimulation (rTMS) during the perioperative period on the incidence of postoperative delirium, postoperative cognitive dysfunction, and chronic postoperative pain in elderly…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Chronic Post-surgical Pain
- Trial name
- NCT06392919
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Affiliated Hospital of Nantong University
Post-Operative Delirium, Postoperative Cognitive Dysfunction
Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery
The purpose of this study is to determine whether brain oxygenation measured by cerebral oximeter has an impact on neurocognitive dysfunction.
- Trial name
- NCT00991328
- Testing
- SctO2 < 60 %.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Anesthesia, Delirium
Anesthesia Depth Increases the Degree of Postoperative Dementia, Delirium, and Cognitive Dysfunction
Anesthetics and anesthesia are suspicious to induce dementia or aggravate preexistent cognitive deficits with or without evoking postoperative delirium.
- Conditions
- Anesthesia, Delirium, Dementia, Bispectral Index Monitor
- Trial name
- BIS & Dementia (NCT02382445)
- Testing
- Anesthesia depth monitor, propofol and sevoflurane
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Heidelberg University
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Pituitary Tumor
Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery
As postoperative cognitive dysfunction rates are high especially in elder patients, cognitive dysfunction is not diagnosed and treated effectively.
- Trial name
- NCT03719781
- Testing
- standardized minimental testing
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Kocaeli University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Risk Factor of POD and POCD After Cardiac Surgery
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common after surgeries in the elderly, especially after cardiothoracic surgery.
- Trial name
- NCT03635229
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- Mahidol University