Clinical trials: Post-operative Complication
Arthritis Knee, Postoperative Nausea
Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty
This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.
- Conditions
- Arthritis Knee, Postoperative Nausea, Postoperative Pain
- Trial name
- NCT04432259
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Henry Ford Health System
Surgical Site Infection
Prevena™ Incisional Negative Pressure Wound Therapy in Re-operative Colorectal Surgery
Many strategies have been attempted to reduce SSI rates. The Centers for Medicare and Medicaid Services introduced the Surgical Care Improvement Project infection project with the aim of reducing SSI incidence and morbidity.
- Trial name
- NCT02509260
- Testing
- Prevena wound management system, Standard wound dressings
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- The Cleveland Clinic
Post Operative Pain, Pain
Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda
A randomized double blind control trial to investigate the safety and efficacy of subcutaneous ketamine for control of post operative pain in low resource settings.
- Trial name
- NCT02514122
- Testing
- Ketamine, Saline
- Where
- Rwanda
- Volunteers
- 61 people
- Sponsor
- University of Saskatchewan
Residual Neuromuscular Blockade in Elderly Patients
The Effect of Age on the Incidence of Postoperative Residual Neuromuscular Blockade
Residual neuromuscular blockade is frequently observed in the early postoperative period when patients have received a general anesthetic with muscle relaxants.
- Trial name
- NCT01545193
- Testing
- Age and incidence of residual neuromuscular blockade
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Endeavor Health
Chronic Pain, Neuropathic Pain
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle
The purpose of this study is to demonstrate safety and efficacy of a new spinal cord stimulation paddle electrode which is able to target the dorsal horns, dorsal nerve roots, and dorsal columns.
- Conditions
- Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
- Trial name
- NCT05045625
- Testing
- HD Study Electrode
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Albany Medical College
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Pain, Postoperative, Postoperative Nausea and Vomiting
Dexamethasone for Post-cesarean Delivery Pain
The purpose of this study is to compare post-cesarean section consumption of pain medication between two groups of patients undergoing scheduled cesarean section at term gestation who receive a single-dose of intraoperative…
- Trial name
- NCT01812057
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University
Post-operative Pain
Postoperative Pain and Morphine Consumption After Mastectomy - Lyrica
This study will compare the effects of oral pregabalin with placebo on postoperative pain and morphine usage after mastectomy. Pregabalin is an anticonvulsant agent approved by the United States Food and Drug Administration (FDA)…
- Trial name
- NCT01391858
- Testing
- lyrica
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas Southwestern Medical Center
Post-operative Infections
Reduction in IV Associated Contamination
The purpose of this study is to investigate whether implementing a novel syringe and IV stopcock cap system impregnated with alcohol will reduce IV catheter bacterial contamination and infections in patients.
- Trial name
- NCT01426217
- Testing
- Passive Bundle PSI (Problem Solving Innovations) Medical HubScrub, PSI Medical DocIt
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bacterial Vaginoses
A Randomized Controlled Trial of Treatment of Bacterial Vaginosis
This is a double-blinded, placebo controlled, multi-center randomized trial of 482 pregnant women who are diagnosed with Bacterial Vaginosis (BV) in the late 3rd trimester (>34 weeks).
- Trial name
- NCT04578015
- Testing
- Metronidazole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Ohio State University
Breast Cancer, Pain, Postoperative
Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction
Each year, the number of breast cancer survivors who choose post-mastectomy breast reconstruction keeps rising. Among women who elect to pursue breast reconstruction, approximately 75% will choose prosthetic breast…
- Conditions
- Breast Cancer, Pain, Postoperative, BRCA1 Mutation, BRCA2 Mutation
- Trial name
- NCT01591746
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Liver Transplantation, Ischemia/Reperfusion Injury
Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transplantation
In this study, the researchers propose to investigate the efficacy of inhaled nitric oxide to prevent ischemia-reperfusion (I/R) hepatocyte injury in patients who receive extended donor criteria(EDC)liver grafts based on changes…
- Conditions
- Liver Transplantation, Ischemia/Reperfusion Injury, Oxidative Injury
- Trial name
- NCT00948194
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Pain, Postoperative
Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery
A prospective, randomized comparison of bupivacaine to liposomal bupivacaine given by local injection at all the wound sites in patients undergoing robotic-assisted or laparoscopic urologic surgeries in an effort to determine…
- Trial name
- NCT02222129
- Testing
- Bupivacaine, liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Knight, Richard, M.D.
Pain, Postoperative
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The objective of this study is to evaluate the safety and clinical utility of the active, SSEC fentanyl 40 micrograms (mcg) for the management of acute, postoperative pain in pediatric participants.
- Trial name
- NCT02395653
- Testing
- fentanyl
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- The Medicines Company
Surgical Site Infection
Topical Antibiotic Irrigation (Gentamicin) in Prophylaxis of Midfacial Fracture Surgical Wounds
The purpose of this study is to evaluate the use of topical antibiotic irrigation (gentamycin) and its ability to reduce surgical site infections in midfacial fracture surgery compared to sterile normal saline (NS).
- Trial name
- NCT03483363
- Testing
- topical irrigation with gentamicin (80mg diluted in 1L 0.9% normal saline), topical irrigation with sterile normal saline (NS), intravenous (IV) prophylactic antibiotic
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- The University of Texas Health Science Center, Houston
Bacterial Infections
Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.
- Trial name
- NCT00423657
- Testing
- ceftaroline, vancomycin plus aztreonam
- Where
- 54 sites in United States, Argentina and 10 more
- Volunteers
- 680 people
- Sponsor
- Forest Laboratories
Residual Paralysis, Post Anesthesia
Best Management of Muscle Relaxation- Objective Monitoring
The purpose of this study is to demonstrate that the investigators can reduce residual paralysis to a very low incidence, and that the investigators can do this while preserving a role for the older and less expensive reversal…
- Trial name
- NCT03958201
- Testing
- Protocol for Management of Muscle Relaxation With Rocuronium Using Objective Monitoring and Reversal With Neostigmine or Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Washington
Pain, Postoperative
Preemptive Local Anesthesia in Vaginal Surgery
Preemptive analgesia is an intervention which provides an anesthetic prior to initiating a painful stimulus. This trial is examining the effects of a local anesthetic given at the point of innervation prior to performing a…
- Trial name
- NCT00318292
- Testing
- bupivacaine and epinephrine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Late Effects of Surgery, Staphylococcus Aureus
Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgery
This investigation is a prospective, open-label pharmacokinetic study of daptomycin prophylaxis in patients undergoing coronary artery bypass graft surgery without valvular replacement.
- Conditions
- Late Effects of Surgery, Staphylococcus Aureus, Surgical Site Infection
- Trial name
- NCT00701636
- Testing
- daptomycin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Post-operative Pain, Anesthesia
Methadone in Ambulatory Surgery
The μ-opioid receptor agonist methadone is frequently used in adult anesthesia and adult pain therapy. Methadone has an extremely long half-life, which confers therapeutic advantage by providing more stable plasma concentrations…
- Trial name
- NCT02300077
- Testing
- methadone, Control (Intra-operative administration of opioids, other than methadone)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
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