Clinical trials: Post-operative Pain Control
Postoperative Pain, Mitral Valve Disease
ESP vs ESP With PECS
Patients scheduled for minimally invasive mitral valve repair. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Trial name
- NCT03592485
- Testing
- Erector Spinae Plane blockade, Pectoral Fascia block, Oxycodone
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Medical University of Lublin
Urinary Tract Diseases
Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures
A prospective, randomized controlled study to determine the efficacy of liposomal bupivacaine given by local injection at all the wound sites in patients undergoing urologic surgeries.
- Trial name
- NCT02805504
- Testing
- Exparel, Marcaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Loma Linda University
Edema, Pain
Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema
The present study is designed to reveal effectiveness of hyaluronidase and dexamethasone on reduction of postoperative edema, pain, trismus, and infection.
- Conditions
- Edema, Pain, Trismus, Infection, Surgical Site
- Trial name
- NCT05466604
- Testing
- Hyaluronidase Injection mesomedica, Dexamethasone dekort
- Where
- 2 sites in Cyprus, Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pain Management, Overweight , Obesity
Safety and Analgesic Efficacy of the Biased μ-Opioid Receptor Agonist Tegileridine for Post-Operative Analgesia in Patients Undergoing Bariatric Surgery
This single-center, stratified randomized double-blind trial tests tegileridine, a new pain drug, for pain relief after weight-loss surgery. Researchers will compare tegileridine with standard opioid pain medicine.
- Conditions
- Pain Management, Overweight , Obesity, Respiration; Sleep Disorder
- Trial name
- NCT07844512
- Testing
- Tegileridine (tegileridine fumarate injection, IV), Sufentanil
- Volunteers
- 148 people
- Sponsor
- The First Hospital of Jilin University
Bariatric Surgery Candidate, Post-operative Pain
Liposomal Bupivacaine for Post-operative Pain Control in Adolescent Bariatric Patients
Liposomal bupivacaine (trade name Exparel) is a local analgesic that is designed to produce more long-term pain control. Bupivacaine, a widely used local analgesic, is stored within liposomes, which break down in soft tissue over…
- Trial name
- NCT06077214
- Testing
- Treatment with liposomal bupivacaine, Treatment with standard bupivacaine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Virginia Commonwealth University
Post Operative Pain
Effects of Adding Dexamethasone Plus Ketamine to Bupivacine in Serrtatus Plane Block
This randomized, double-blind trial included 60 female patients undergoing modified radical mastectomy. The study carried out at National Cancer Institute, cairo university after approval of the local ethical committee.
- Trial name
- NCT05775393
- Testing
- Serratus anterior plane block for MRM
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Pain, Vertigo
Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy
The investigators hypothesize that the use of tramadol will reduce pain and analgesic consumption after arthroscopic shoulder surgery.
- Conditions
- Pain, Vertigo, Nausea, Pruritus
- Trial name
- NCT02247648
- Testing
- tramadol
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Breast Surgery, Thoracic Paravertebral Block
Erector Spinae Plane Block Versus Thoracic Paravertebral Block for Pain Control in Modified Radical Mastectomy
The aim of the study is to compare the effectiveness of the Erector spinae plane (ESP) block versus thoracic paravertebral (TPV) block in the post-operative pain control after radical mastectomy.
- Conditions
- Breast Surgery, Thoracic Paravertebral Block, Post-operative Pain Control, Erector Spinae Plane Block
- Trial name
- NCT04457115
- Testing
- Thoracic paravertebral block, Erector spinae plane Block
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- AUSL Romagna Rimini
Inguinal Hernia, Ventral Hernia
Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs
While studies have shown improved postoperative pain control with TAP blocks after inguinal and ventral hernia repair, data comparing Liposomal bupivacaine (Exparel) to bupivacaine alone in formulation of the TAP block is…
- Trial name
- NCT05177991
- Testing
- Liposomal Bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Leslie Son
Rotator Cuff Tear, Pain, Postoperative
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
This document is a protocol for a human research study. This study is to be conducted according to United States standards of Good Clinical Practice in accordance with applicable Federal regulations and institutional research…
- Trial name
- NCT03822182
- Testing
- liposomal bupivicaine, Dexamethasone
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Indiana University
Amputation, Amputation of Lower Limb
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.
- Conditions
- Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss
- Trial name
- VANISH (NCT06908538)
- Testing
- cryoablation
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- AtriCure, Inc.
Post-operative Pain
Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant Patients
A randomized clinical study evaluating the effect of buprenorphine/naloxone (bup/nx) sublingual film on postoperative pain management in opioid-tolerant patients.
- Trial name
- NCT04771689
- Testing
- Buprenorphine/Naloxone
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Post Operative Pain
Analgesia After Video-Assisted Thoracic Surgery
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
- Trial name
- NCT05094323
- Testing
- Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine, Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Postoperative Pain
0.15 mg Spinal Morphine vs. no Treatment for Morphine Requirement After VATs.
Postoperative pain after Video-assisted Thoracoscopic Surgery (VAT) is still debating. Therefore the investigators conduct a study comparing 0.15 mg spinal morphine and control group in term of analgesia.
- Trial name
- NCT01979354
- Testing
- Spinal morphine
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Patient-Controlled Analgesia
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery.
- Trial name
- POPCORN (NCT06186141)
- Testing
- Morphine, Oxycodone
- Where
- Australia
- Volunteers
- 690 people
- Sponsor
- Murdoch Childrens Research Institute
Hepatectomy, Analgesia, Epidural
Bupivacaine Levels in Liver Resection Patients
Bupivacaine is a local anesthetic commonly used to manage postoperative pain. Liver resection patients typically have an epidural catheter placed preoperatively through which they receive a continuous infusion of bupivacaine and…
- Trial name
- NCT03145805
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Jessica Burjorjee, MD, FRCPC
Postoperative Pain
A Comparison of Epidural Block With Adding Sciatic Block to Continuous Femoral Block in Total Knee Arthroplasty
The investigators compared continuous epidural infusion with combined continuous femoral and single-shot sciatic nerve blocks. The primary outcome was the incidence of side effects, and secondary outcomes were pain relief, motor…
- Trial name
- NCT02235506
- Testing
- epidural infusion, femoral sciatic
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yeungnam University College of Medicine
Pain, Postoperative, Local Anesthetic
The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty
On average, more than 130 Americans die every day from opioid overdose. Surgeons provide 37% of all opioid prescriptions in the United states, second only behind pain management physicians.
- Trial name
- NCT04377204
- Testing
- marcaine bupivacaine, Lidocaine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Pain, Postoperative
Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty
Lipoabdominoplasty and liposuction are one of the most common plastic surgeries. The management of postoperative pain is complex.
- Trial name
- KEMPLA (NCT02450214)
- Testing
- Saline, Ketamine, Ketamine + magnesium
- Where
- Chile
- Volunteers
- 63 people
- Sponsor
- University of Chile
Post Operative Pain
Analgesic Effect of M-TAPA on LC
Objective: To investigate the postoperative analgesic efficacy of M-TAPA block and its effect on opioid consumption in patients undergoing laparoscopic cholecystectomy (LC) surgery.
- Trial name
- NCT05891652
- Testing
- modified thoracoabdominal nerve block through perichondrial approach
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Cumhuriyet University
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