Clinical trials: Post-operative Pain Control
Spine Fusion, Locoregional Anaesthesia
PeriOPerative Spine Surgery COntrol Pain (POPSSCOP) Study: Intrathecal Morphine vs Erector Spinae Plane Block for Postoperative Pain Management in Spinal Fusion
This is a prospective observational study conducted at the trauma center of Città della Salute e della Scienza of Turin. The aim of the study is to compare two local regional anesthesia techniques in multimodal analgesia for…
- Conditions
- Spine Fusion, Locoregional Anaesthesia, Intrathecal Anesthesia, Erector Spina Plan Block
- Trial name
- POPSSCOP (NCT07245524)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Pain
The Effectiveness of Gabapentin for Post-operative Pain Following Cesarean Section
Gabapentin has been very effective at treating pain after knee and hip operations, hysterectomies, and many other types of operations.
- Trial name
- NCT01094925
- Testing
- lactose, Gabapentin 300mg, Gabapentin 600mg
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Post Operative Pain, Cesarean Section Complications
Quercetin Effect on Post-ceserean Pain
The cesarean section is a common gynecological surgery, requiring effective pain management to prevent complications and immobility.
- Trial name
- NCT06650891
- Testing
- Quercetin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Future University in Egypt
Post Operative Pain, Acute, Renal Transplant Donor of Left Kidney
Effectiveness of Thread Embedding Acupuncture Analgesia at the EX-B2 Point Combined With Standard Therapy After Laparoscopic Living Donor Nephrectomy
Kidney transplantation is the main option besides hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) to prolong and improve the quality of life for patients with end-stage renal disease.
- Conditions
- Post Operative Pain, Acute, Renal Transplant Donor of Left Kidney, Quality of Life, Acupuncture Analgesia
- Trial name
- NCT06197620
- Testing
- Thread embedding acupuncture and standard therapy
- Where
- Indonesia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Post-operative Pain
Intraoperative TAP Block After Repeat Cesarean
The aim of this study is to perform a randomized trial to investigate if intraoperative surgeon administered TAP block reduces pain and use of oral and parenteral pain medications after repeat cesarean delivery.
- Trial name
- NCT05393908
- Testing
- TAP Block Group
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Surgery
Green Light for Post-Operative Wellness
This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside.
- Trial name
- GLOW (NCT07218289)
- Testing
- Bright Green Light Therapy, Dim White Light Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rebecca E Kotcher, MD
Tibial Plateau Fracture
Continuous Femoral Nerve Block With a Tibial Plateau Fracture
The primary purpose of the proposed study is to compare postoperative pain scores and total opioid consumption between two groups randomized to either receive or not receive a femoral nerve block for pain control following…
- Trial name
- NCT02168959
- Testing
- bupivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Breast Cancer, Mastectomy
A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia
In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain.
- Conditions
- Breast Cancer, Mastectomy, Pain, Chronic, Pain, Post Operative
- Trial name
- RELIEF (NCT05146778)
- Testing
- Opioid-free anesthesia, Conventional opioid-based anesthesia
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Gangnam Severance Hospital
Postoperative Pain
Evaluation of the Efficacy and Safety of HTX-011 for Postoperative Analgesia Following Abdominoplasty Surgery
A Phase 2, Randomized, Controlled Evaluation of the Efficacy and Safety of HTX-011 or HTX-002 for Post-Operative Analgesia Following Abdominoplasty Surgery
- Trial name
- NCT02689258
- Testing
- HTX-011B, HTX-011A, HTX-002
- Where
- 8 sites in United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Heron Therapeutics
Post Operative Pain
Efficacy and Safety Trial to Evaluate the Sufentanil NanoTab® PCA System/15 mcg (Zalviso™) for Post-Operative Pain in Patients After Knee or Hip Replacement Surgery
The purpose of this study is to compare the efficacy and safety of the Sufentanil NanoTab PCA System/15 mcg to the Placebo Sufentanil NanoTab PCA System for the management of acute moderate to severe post-operative pain after…
- Trial name
- NCT01660763
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- United States
- Volunteers
- 419 people
- Sponsor
- Talphera, Inc
Total Hip Arthroplasty, Postoperative Pain
PENG, Suprainguinal Fascia Iliaca Block, and Control After Total Hip Arthroplasty
Total hip arthroplasty can cause significant pain after surgery. Regional anesthesia techniques, such as the pericapsular nerve group (PENG) block and the suprainguinal fascia iliaca plane block, may help reduce postoperative…
- Trial name
- NCT07879521
- Testing
- Pericapsular nerve group (PENG) block, Suprainguinal Fascia Iliaca Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Uludag University
Quadratus Lumborum, Laparoscopic Cholecystectomy
Comparison of Ultrasound-Guided Quadratus Lumborum Plane Block Versus Intraperitoneal and Periportal Bupivacaine Infiltration in Postoperative Analgesia After Laparoscopic Cholecystectomy
The primary outcome: is measured by pain at rest and upon mobilization according to VAS. VAS for pain (ranging from 0 to 10, where 0 no pain and 10 maximum pain) will be evaluated postoperatively and every 2 hours during the…
- Conditions
- Quadratus Lumborum, Laparoscopic Cholecystectomy, Ultrasound Guided, Post Operative Analgesia
- Trial name
- NCT06721039
- Testing
- Bilateral QL block, Intraperitoneal and port sites infiltration
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- medina medical center
Breast Cancer, Postoperative Recovery
ERAS Protocols in Breast Conserving Surgery
Enhanced Recovery After Surgery (ERAS) protocols have been of increasing interest in the surgical community for decades. The emphasis has been development of protocols to maximize pain control post-operatively without the use of…
- Trial name
- ERAS (NCT06938581)
- Testing
- ERAS Protocol, Standard Perioperative Care
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Nebraska
Obstructive Sleep Apnea
Post-Operative Steroids After Sleep Surgery
The primary objective of this randomized, placebo-controlled, double-blind study will be to determine if postoperative steroids significantly improve subjects' pain compared to a placebo after undergoing sleep surgery.
- Trial name
- NCT06818981
- Testing
- 8mg dexamethasone
- Where
- United States
- Sponsor
- Medical University of South Carolina
Postoperative Bleeding
Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
Tranexamic acid (TXA) is an anti-fibrinolytic agent developed in the 1960s that has been safely used to reduce blood loss, transfusion rates and bleeding-associated mortality in trauma, obstetrics and orthopedic surgery…
- Trial name
- TXA (NCT06208267)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Acute, Post-operative Pain
Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ST-2427
This randomized, double-blind, placebo controlled, study will be conducted to evaluate the safety, tolerability, and pharmacokinetics of ST-2427.
- Trial name
- NCT04475198
- Testing
- ST-2427
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SiteOne Therapeutics, Inc.
Pain, Postoperative
Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty
This is a Phase 3, multicenter, randomized, double-blind, parallel-group, placebo-controlled efficacy and safety study of postoperative pain in adults who are scheduled for unilateral inguinal hernioplasty via open laparotomy…
- Trial name
- MATRIX-2 (NCT02525133)
- Testing
- XaraColl
- Where
- 24 sites in United States
- Volunteers
- 319 people
- Sponsor
- Innocoll
Pain, Procedural
The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
The purpose of this study is to compare patient responses during and after surgery when local anesthetic is used for dental treatment under general anesthesia (GA) and when it is not used.
- Trial name
- NCT04500158
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Medial Patellofemoral Ligament (MPFL) Reconstruction, Sports Injuries in Children
Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population
The goal of this randomized clinical trial is to determine if administration of Exparel via local infiltration for medial patellofemoral ligament (MPFL) reconstruction procedures in pediatric orthopaedic sports medicine patients…
- Conditions
- Medial Patellofemoral Ligament (MPFL) Reconstruction, Sports Injuries in Children, Analgesia, Pain, Postoperative
- Trial name
- NCT06559215
- Testing
- Exparel
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Post Operative Pain, Laparoscopic Hysterectomy
Preoperative Acetazolamide
The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain.
- Conditions
- Post Operative Pain, Laparoscopic Hysterectomy, Referred Pain
- Trial name
- NCT07101250
- Testing
- Acetazolamide 500 MG Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Prisma Health-Upstate
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