Clinical trials: Post-operative Pain Control
Pain, Acute, Knee Arthropathy
Comparison of Regional Anesthesia Techniques After Total Knee Arthroplasty
Comparison of continuous adductor canal block to continuous femoral nerve block in patients after total knee arthroplasty. All patients will be anesthetized with spinal anesthesia.
- Conditions
- Pain, Acute, Knee Arthropathy, Postoperative Pain, Mobility Limitation
- Trial name
- NCT03143738
- Testing
- continuous anesthesia of adductor canal, continuous anesthesia of femoral nerve, Spinal anesthesia
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Postoperative Pain
Caudal Block v/s Local Wound Infiltration for Pain Control in Pediatric Patients After Operation for Inguinal Hernia
This randomized controlled trial aims to compare the analgesic efficacy of local wound infiltration with Ropivacaine versus Caudal Block with Ropivacaine in pediatric patients undergoing surgery for inguinal hernia
- Trial name
- NCT07747038
- Testing
- Caudal Block with Ropivacaine Intervention, Local Wound Infiltration with Ropivacaine Intervention, Intravenous Paracetamol Suspension Intervention
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Memorial Hospital
Post-operative Pain
Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant Patients
A randomized clinical study evaluating the effect of buprenorphine/naloxone (bup/nx) sublingual film on postoperative pain management in opioid-tolerant patients.
- Trial name
- NCT04771689
- Testing
- Buprenorphine/Naloxone
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Pain
Intravenous Lidocaine Infusion During Video-assisted Thoracic Procedures for Improved Pain Control
The purpose of this study is to determine whether intravenous lidocaine infusion during a video-assisted chest surgery is effective in reducing the pain involved after the surgery.
- Trial name
- NCT01277835
- Testing
- Lidocaine Infusion
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Saskatchewan
Collapse of Thoracic Vertebra, Collapse of Lumbar Vertebrae
Study of Dexmedetomidine in Spine Surgery
The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups.
- Trial name
- NCT01850017
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pain, Analgesia
Post-Operative Pain Scores and Analgesic Requirements After Elective Inguinal Herniorrhaphy
The study will investigate the effects of single dose pre-operative oral dose of gabapentin (1200) on post -operative pain scores and oral analgesic requirements.
- Conditions
- Pain, Analgesia, Hernia, Inguinal
- Trial name
- NCT00735124
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Oklahoma
Post-operative Pain
Added Value of Local Clonidine for Spine Postoperative Pain Control, in Addition to Bupivacaine
The objective of this prospective randomized double-blind study is to evaluate the added analgesic value of clonidine to the conventional local bupivacaine wound infiltration in posterior spine surgery.
- Trial name
- NCT01902108
- Testing
- Bupivacaine, Clonidine
- Where
- Lebanon
- Volunteers
- 225 people
- Sponsor
- St Joseph University, Beirut, Lebanon
Pain, Postoperative, Shoulder Osteoarthritis
Effective Pain Management During Shoulder Replacement Surgery With EXPAREL
The purpose of this study is to examine the effectiveness of post-operative pain control of local infiltration (LIA) of EXPAREL administration to ropivacaine administered via continuous interscalene nerve block (CINB) for…
- Trial name
- NCT03474510
- Testing
- local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block
- Where
- United States
- Sponsor
- TriHealth Inc.
Postoperative Pain Control in Surgical Neonates
The Use of Ketorolac in Surgical Neonates
The general purpose of this study is to characterize the safety profile of ketorolac in infants age 0-3 months. Our hypothesis is that ketorolac is safe in neonates, and effective in controlling pain with less narcotic…
- Trial name
- NCT01667120
- Testing
- Ketorolac
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Local Anesthetics, Analgesia
Liposomal vs. Conventional Bupivacaine for Pain Control
The goal of this pilot study is to test the hypothesis that liposomal bupivacaine extends the duration of paravertebral block in patients undergoing radical nephrectomy, achieving improved analgesia compared to conventional…
- Conditions
- Local Anesthetics, Analgesia, Regional Block, Paravertebral Block
- Trial name
- NCT06231355
- Testing
- Performing paravertebral nerve block with lipo-bupivacaine, Performing paravertebral nerve block with bupivacaine
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Peking University First Hospital
for Post-operative Pain Relief in Spine Surgeries
Low Dose Perioperative Ketamine Infusion and it's Effect on Postoperative Pain Score, Sedation Score and Narcotic Consumption in Patients Undergoing Spine Surgery: A Prospective Randomized Double Blind Control Trial.
Low dose perioperative ketamine infusion and it's effect on postoperative pain score, sedation score and narcotic consumption in patients undergoing spine surgery: A prospective randomized double blind control trial.
- Trial name
- NCT04259476
- Testing
- Ketamine Hydrochloride
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Pain, Inflammation
Efficacy and Safety of Postoperative Intravenous Parecoxib Sodium Followed by Oral Celecoxib in Osteoarthritis Patients
In mainland China, knee Osteoarthritis (OA) is the leading cause of disability in older persons. Total knee arthroplasty (TKA) is now generally regarded by orthopaedic surgeons and patients as an effective treatment for end-stage…
- Trial name
- NCT02198924
- Testing
- Parecoxib and Celecoxib
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Peking Union Medical College Hospital
Acute Post-operative Pain
Ibuprofen Use on Post-operative Pain Following Cholecystectomy
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
- Trial name
- NCT06478758
- Testing
- Ibuprofen 400 mg, Acetaminophen 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Giresun University
Pain
Bupivacaine Injections Into Uterosacral Ligaments During Robotic Assisted Total Hysterectomies
Will patients that receive injections of Marcaine into the uterine nerve via the uterosacral ligaments experience less pain postoperatively, need less narcotic pain medication and return to activities of daily living sooner.
- Trial name
- NCT02230735
- Testing
- Bipivacaine 0.5% with epinephrine, Normal Saline
- Where
- United States
- Sponsor
- Souza, Amanda, M.D.
Pain, Postoperative, Hernia, Ventral
An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries
This is a multicenter, Phase 3, open-label, safety, tolerability, and characterization of pharmacokinetics study of the INL 001 (bupivacaine HCl) implant, at 300 mg, in patients following various soft-tissue surgeries: open…
- Conditions
- Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy
- Trial name
- NCT04785638
- Testing
- INL-001 (bupivacaine hydrochloride) implant
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Innocoll
Post Operative Analgesia, Hemodynamic (MAP) Stability
Comparative Study of USG Guided ESPB vs USG Guided PVB For Post-op Analgesia In Patient's After Open Renal Surgeries
Pain control following open renal surgeries are of utmost importance in order to reduce the chance of chronic pain development, and facilitate early rehabilitation.
- Conditions
- Post Operative Analgesia, Hemodynamic (MAP) Stability, Renal Surgeries, Hypertension
- Trial name
- NCT06728514
- Testing
- Erector spinae plane block group., Paravertebral Nerve Block, Inj Bupivacaine
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sahiwal medical college sahiwal
Chronic Pain
Ketamine and Magnesium in Post-operative Pain Control in Patients Treated With Opioids
The goal of this research proposal is to determine if the intraoperative administrative of Ketamine and Magnesium during laparoscopic gynecologic surgery improves postoperative pain in patients on chronic opioid therapy for…
- Trial name
- NCT02940509
- Testing
- Ketamine plus Magnesium sulfate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Post Operative Pain, Hyperalgesia
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery.
- Trial name
- NCT01594047
- Testing
- ketamine infusion, Methadone PCA
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
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