Clinical trials: Post-operative Pain Management
Spine Fusion, Postoperative Pain
Suzetrigine (Journavx) for Pain Management After Spine Surgery
This prospective, single-center interventional study will evaluate the effect of suzetrigine (Journavx), a selective NaV1.8 inhibitor, on postoperative opioid requirements in patients undergoing spine surgery.
- Trial name
- NCT07829718
- Testing
- Suzetrigine (Journavx)
- Volunteers
- 110 people
- Sponsor
- Ohio State University
Inguinal Hernia, Ventral Hernia
Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs
While studies have shown improved postoperative pain control with TAP blocks after inguinal and ventral hernia repair, data comparing Liposomal bupivacaine (Exparel) to bupivacaine alone in formulation of the TAP block is…
- Trial name
- NCT05177991
- Testing
- Liposomal Bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Leslie Son
Pain Management in Breast Surgery, Pain After Surgery
Comparison of the Analgesic Efficacy of Erector Spinae Plane Block in Breast-Conserving Surgery Versus Serratus Anterior Block Combined With Additional Pecto-Intercostal II Block
This prospective randomized study will compare the effects of Erector Spinae Plane Block (ESPB) and Serratus Anterior Plane Block combined with Pectoral Nerve Block Type II (SAPB + PECS II) on intraoperative analgesia and…
- Conditions
- Pain Management in Breast Surgery, Pain After Surgery, Regional Anaesthesia
- Trial name
- NCT07368413
- Testing
- SAPB + PECS II Technique, Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Kayseri City Hospital
Irreversible Pulpitis
Dexketoprofen Trometamol in Postoperative Endodontic Pain
The purpose of this study is to investigate the analgesic efficacy of multiple doses of Dexketoprofen Trometamol 25 mg on postoperative pain following emergency endodontic treatment in teeth with irreversible pulpitis, using as…
- Trial name
- DTPEP (NCT02086097)
- Testing
- Dexketoprofen trometamol, Ibuprofen
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Daniel Chavarría Bolaños
Pain, Postoperative
Compare Celecoxib and Ibuprofen Sr In The Management Of Acute Pain Post Orthopedic Or Gynecological Surgery
To validate the analgesic efficacy and safety of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery
- Trial name
- NCT00150280
- Testing
- celecoxib and ibuprofen SR
- Where
- 6 sites in China
- Volunteers
- 132 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Amputation, Amputation of Lower Limb
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.
- Conditions
- Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss
- Trial name
- VANISH (NCT06908538)
- Testing
- cryoablation
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- AtriCure, Inc.
Post-operative Pain
Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant Patients
A randomized clinical study evaluating the effect of buprenorphine/naloxone (bup/nx) sublingual film on postoperative pain management in opioid-tolerant patients.
- Trial name
- NCT04771689
- Testing
- Buprenorphine/Naloxone
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Pain, Postoperative
Nicotine Administration and Post-operative Opioid Use With Bariatric Surgery
This prospective, randomized, double-blind study will enroll nonsmoking female subjects undergoing laparoscopic bariatric surgery under general anesthesia.
- Trial name
- NCT01194089
- Testing
- Nasal Nicotine Spray, Nasal Normal Saline Spray
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Toby Weingarten
Pain, Postoperative
A Novel, Potent and Non-addictive Analgesic of Combinations for Knee Replacement Moderate to Severe Pain Management
To assess the safety, efficacy, and pharmacokinetics of oral SafeTynadol, Naldebain and Naldebain combine with SafeTynadol in the treatment of moderate to severe pain following knee replacement.
- Trial name
- NCT05842733
- Testing
- Naldebain, SafeTynadol, Naldebain + SafeTynadol
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Sinew Pharma Inc.
Pain Management
Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy
The study evaluates the effectiveness and safety of IV tramadol compared to placebo managing postoperative pain following a bunionectomy
- Trial name
- NCT03290378
- Testing
- Tramadol
- Where
- 5 sites in United States
- Volunteers
- 409 people
- Sponsor
- Avenue Therapeutics, Inc.
Pain, Postoperative
Intercostal Nerve Cryoablation for Postoperative Pain Management
The purpose of the study is to assess the efficacy of intercostal nerve cryoablation on the magnitude and duration of postoperative pain control both in patients undergoing thoracoabdominal incisions for the descending or…
- Trial name
- NCT03972397
- Testing
- Intercostal Nerve Cryoablation, Bupivacaine liposomal injectable suspension, Patient-controlled analgesia (PCA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Post Operative Pain
Analgesia After Video-Assisted Thoracic Surgery
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
- Trial name
- NCT05094323
- Testing
- Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine, Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Assiut University
Caffeine, Pain, Joint
Pain Management After Shoulder Arthroplasty
Pain control is a critical after many surgical procedures. It is well known that orthopaedic surgeries are among the most painful procedures, with total joint arthroplasty being a clear example of this situation.
- Trial name
- NCT04872270
- Testing
- Total Shoulder Arthroplasty, Caffeine Pill, Percocet 10Mg-325Mg Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Laparoscopic Appendectomy, Pain Management
Comparing N-Acetylcysteine (NAC) Versus Alpha-Lipoic Acid (ALA) as Adjuncts for Postoperative Pain Management After Laparoscopic Appendectomy
Postoperative pain remains a major concern following laparoscopic appendectomy, despite advances in minimally invasive surgery and multimodal analgesia.
- Conditions
- Laparoscopic Appendectomy, Pain Management, Anti Oxidative Stress
- Trial name
- NCT07360379
- Testing
- N Acetyl Cysteine, Alpha-Lipoic Acid (ALA)
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Pain, Postoperative, Tonsillar Hypertrophy
Management of Post-Tonsillectomy Pain in Pediatric Patients
Single-center, randomized, open-label, non-inferiority treatment pilot study to evaluate the effectiveness of a combined acetaminophen and ibuprofen regimen for treatment of post-operative tonsillectomy pain in the pediatric…
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis
- Trial name
- NCT04551196
- Testing
- Alternating Acetaminophen and Ibuprofen, Combined Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Postoperative Pain
Pharmacokinetic Evaluation of Anrikefon Injection in the Geriatric Population With the Management of Acute Pain Following Abdominal Laparoscopy
This study used a single-center, single-arm, pharmacokinetic ( PK ) study design. Thirty subjects who met the inclusion criteria were stratified according to age, including 15 in each age group of 65-74 years old and ≥ 75 years…
- Trial name
- PAGAP1 (NCT07353983)
- Testing
- Inject Anrikefon Injection
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postoperative Pain
A Comparison Study Between Ketamine Versus Tramadol for Pain Management After Major Upper Abdominal Surgery
The purpose of the study is the comparison between ketamine and tramadol, regarding the analgesia quality and efficiency, in patients receiving Patient Controlled Analgesia (PCA) morphine, after major upper abdominal surgeries…
- Trial name
- NCT02499341
- Testing
- Tramadol, Ketamine
- Where
- Greece
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Patient-Controlled Analgesia
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery.
- Trial name
- POPCORN (NCT06186141)
- Testing
- Morphine, Oxycodone
- Where
- Australia
- Volunteers
- 690 people
- Sponsor
- Murdoch Childrens Research Institute
Postoperative Pain
A Comparison of Epidural Block With Adding Sciatic Block to Continuous Femoral Block in Total Knee Arthroplasty
The investigators compared continuous epidural infusion with combined continuous femoral and single-shot sciatic nerve blocks. The primary outcome was the incidence of side effects, and secondary outcomes were pain relief, motor…
- Trial name
- NCT02235506
- Testing
- epidural infusion, femoral sciatic
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yeungnam University College of Medicine
Open Nephrectomy Surgery
Rhomboid Intercostal and Subserratus Plane Block Versus Quadratus Lumborum Block in Management of Postoperative Pain After Open Nephrectomy
Rhomboid intercostal block (RIB) and Rhomboid intercostal block with sub-serratus plane block (RISS) are the two types of plane blocks used for postoperative analgesia after abdominal surgeries.
- Trial name
- Nephrectomy (NCT06983249)
- Testing
- Rhomboid intercostal and Sub-serratus nerve block in nephrectomy, Quadratus lumborum nerve block in nephrectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
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