Clinical trials: Post-surgical Dental Pain
Postoperative Pain
Efficacy of EXPAREL in Comparison to Standard of Care for the Treatment of Post Operative Dental Implant Pain
This study is researching managing postsurgical pain by injecting both short-acting local anesthetics and EXPAREL® at the time of surgery and reviewing if it could reduce or eliminate the need for postsurgical opioids and improve…
- Trial name
- FAST (NCT02533440)
- Testing
- EXPAREL and Local Anesthetics, Oral Opioid and Local Anesthetics
- Where
- 3 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Bellaire Facial Surgery Center
Photobiomodulation, Endodontic Disease
Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery
The objective of this study will be to evaluate if photobiomodulation (FBM) can reduce postoperative pain in patients who will undergo endodontic surgery.
- Conditions
- Photobiomodulation, Endodontic Disease, Pain, Inflammation
- Trial name
- NCT05935306
- Testing
- Ibuprofen, Photobiomodulation simulation, Photobiomodulation
- Where
- Uruguay
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Post-Op Complication, Endodontic Inflammation
Postoperative Pain After Using NiTi Instruments
The aim of this randomized clinical trial was to compare the incidence, intensity and duration of postoperative pain following the removal of root canal obturation materials canals using rotary (ProTaper Universal or Hyflex EDM)…
- Conditions
- Post-Op Complication, Endodontic Inflammation, Endodontically Treated Teeth, Apical Periodontitis
- Trial name
- NCT04700995
- Testing
- NiTi instruments
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Trakya University
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Dental Pain
A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo
Researchers are looking for a better way to relieve pain in people, such as after dental surgery. Participants in this study, have had 3 or 4 third molars (cheek teeth) removed and subsequently have moderate to severe tooth pain.
- Trial name
- NCT05485805
- Testing
- Naproxen sodium and caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Bayer
Anxiety, Dental, Post Operative Pain
Effectiveness of Green Color Exposure on Dental Anxiety
The investigator's aim in this study was to evaluate the preoperative anxiety and the pain felt during the operation due to exposure to green light.
- Trial name
- NCT05584696
- Testing
- Green light exposure, Normal light exposure
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Acute Pain
Epigenetic Influences on Post-Surgical Acute and Chronic Pain
Pain is the way our brain interprets certain bodily sensations. It is very difficult to describe or to put into words as perception and tolerance of pain varies widely between individuals.
- Trial name
- NCT02002520
- Where
- 2 sites in Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Analgesia
A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery (Study P05800)
Patients will receive a single intravenous (IV) infusion administered over 3 minutes of either ORG 28611 (SCH 900111), 0.12 mg/kg morphine sulphate, or placebo, within 6 hours after dental surgery, when they experience moderate…
- Trial name
- NCT00782951
- Testing
- Org 28611, morphine sulfate
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Pain
Study Evaluating the Efficacy of an Ibuprofen Effervescent Tablet in the Treatment of Post-Surgical Dental Pain
Evaluation of the efficacy and safety of a single dose of an ibuprofen effervescent tablet in the treatment of pain following third molar extraction in comparison to single doses of placebo, standard ibuprofen tablets, and…
- Trial name
- NCT00631111
- Testing
- effervescent ibuprofen tablets, effervescent Aspirin plus Vitamin C tablets, ibuprofen tablets
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pain, Postoperative, Dental Pain
A Study of Acetaminophen for Post Surgical Dental Pain
To assess the safety, tolerability, analgesic, efficacy and pharmacokinetics of high dose acetaminophen relative to placebo and low dose acetaminophen relative to placebo over a 24 hour period in patient experiencing moderate to…
- Trial name
- NCT04018612
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Tooth Impaction | {Tooth} | Dental, Corticosteroid
Comparison of the Effects of Protocols Applied After Surgical Extraction of Impacted Mandibular Third Molars
Following the surgical extraction of the most commonly impacted mandibular third molars, the first group was planned to receive methylprednisolone, the second group hyaluronic acid, the third group ozone therapy, the fourth group…
- Conditions
- Tooth Impaction | {Tooth} | Dental, Corticosteroid, Hyaluronic Acid, Ozone
- Trial name
- NCT06900907
- Testing
- Diode laser, Hyaluronic acid, Ozone
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Batman University
Dental Pain
Dental Pain Study of Analgesics in Patients Undergoing Molar Removal
Accessing the efficacy and safety of pregabalin when used alone and in combo with acetaminophen in a dental pain model. To test whether pre-operative dose of pregabalin increases the time to significant post-operative pain (NRS ≥…
- Trial name
- NVK009-0001 (NCT03652818)
- Testing
- Pre-Op pregabalin, Post-Op pregabalin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Post-op Pain
Study to Assess Dopamine Receptor Modulation With Rotigotine to Enhance Morphine Analgesia in the Dental Model
Narcotics are widely used as the mainstay of pain treatment, although increasing doses are required over time as the individual becomes tolerant to their effects.
- Trial name
- NCT02123979
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Dental Pain
Methodological Validation of Ibuprofen Verses Placebo for Post Operative Pain After Third Molar Extraction Surgery
This is a single center placebo controlled, prospective, randomized study on healthy adults undergoing third molar surgery.
- Trial name
- NCT02096926
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
To Control Pain After Third Molar Surgery
Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery
To compare analgesic effects of preoperative administration of paracetamol 500 milligram plus codeine 30 milligram in single-tablet and effervescent formulation to ibuprofen 400 milligram, and placebo in the management of…
- Trial name
- NCT04730297
- Testing
- paracetamol 500 mg plus codeine 30 mg preoperative administration, ibuprofen 400 mg preoperative administration
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Periodontal Disease, Tissue Adhesive
The Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing
Periodontal disease is a gum infection caused by plaque on teeth containing both bacteria and calculus (hard) deposits. These need to be removed on a regular basis to maintain gum health and to prevent teeth weakening.
- Conditions
- Periodontal Disease, Tissue Adhesive, Dental Scaling, Wound Healing
- Trial name
- NCT02826109
- Testing
- PeriAcryl®90 HV
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Root Canal Therapy, Persistent Tooth Pain
DPBRN Persistent Pain and Root Canal Therapy
The purpose of this study is to document by survey the occurence of tooth pain present 3 months and 6 months after root canal therapy in the patients recruited for the DPBRN "Peri-operative tooth pain" study.
- Trial name
- NCT01201668
- Where
- 8 sites in United States, Denmark
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Dental Pain
Study of Naproxen Capsules to Treat Dental Pain
The purpose of the study is to determine whether Naproxen Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT01229228
- Testing
- Naproxen Test, Naprosyn
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Iroko Pharmaceuticals, LLC
Periapical Diseases, Postoperative Dental Pain
Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer
In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has…
- Conditions
- Periapical Diseases, Postoperative Dental Pain, Irrigation Solution, Photodynamic Therapy (PDT)
- Trial name
- NCT06752655
- Testing
- Curcumin with photodynamic thearpy, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Virtual Reality, Relaxation
Evaluation of the Effect of Relaxation Exercise and Virtual Reality Application After Impacted Third Molar Dental Surgery
Impacted tooth extractions are the most frequently performed procedure in oral surgery. Complications such as pain and trismus are frequently observed after surgery.
- Conditions
- Virtual Reality, Relaxation, Third Molar Surgery, Pain
- Trial name
- NCT06917989
- Testing
- Relaxation Exercise, Virtual Reality Application, Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey