Clinical trials: Post-surgical Wound Healing
Degenerative Mitral Valve Disease
Long Term Results in Redo Mitral Valve Surgery After Mitral Valve Repair
The current gold standard for severe mitral regurgitation is mitral valve plasty (PLM). The surgery allows the repair of the mitral valve, therefore without the need for mitral valve replacement (SVM), which involves the…
- Trial name
- NCT05839782
- Testing
- Mitral valve repair (PLM), Mitral valve replacement
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Michele De Bonis
Ventral Hernia
Microlyte in Prevention of SSI After Open Ventral Hernia Repair
Participants who are scheduled to have open ventral hernia repair (OVHR) will be asked to take part in this study. The purpose of this study is to find out if placing Microlyte (which is a dissolvable sheet coated in silver) on…
- Trial name
- NCT05093894
- Testing
- Group 1
- Where
- 3 sites in United States
- Sponsor
- Prisma Health-Upstate
Pain, Postoperative, Rebound Pain
Intravenous Dexamethasone With Single-Shot Versus Continuous Brachial Plexus Block for Rebound Pain After Shoulder Surgery
Shoulder surgery often causes severe pain after the operation. To control this pain, doctors commonly perform a nerve block (interscalene brachial plexus block), which numbs the shoulder area.
- Conditions
- Pain, Postoperative, Rebound Pain, Shoulder Injuries, Rotator Cuff Injuries
- Trial name
- NCT07699744
- Testing
- Dexamethasone (IV), Single-shot interscalene brachial plexus block, Continuous interscalene brachial plexus block
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Seoul National University Hospital
Gingival Overgrowth, Gingival Hyperplasia
Effect of Injectable Platelet-rich Fibrin (i-PRF) on Wound Healing After Gingivectomy
This study evaluates the clinical and biochemical effects of injectable platelet-rich fibrin (i-PRF) on wound healing after gingivectomy, a surgical procedure used to treat gingival overgrowth.
- Trial name
- i-PRF-GIN (NCT07785349)
- Testing
- injectable Platelet-Rich Fibrin (i-PRF), Conventional Gingivectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Şeyma Çardakçı
Laparoscopic Surgery, Laparoscopic Appendectomy
Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery
Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative…
- Conditions
- Laparoscopic Surgery, Laparoscopic Appendectomy, Laparoscopic Cholecystectomy, Laparoscopic Hernia Repair Surgery
- Trial name
- NCT07626463
- Testing
- Pre-incisional infiltration with ropivacaine and diprospan, Pre-incisional infiltration with ropivacaine alone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Enterocutaneous Fistula
Assessment of Relation Between Recurrence of Enterocutaneous Fistula and Preoperative C-reactive Protein Level After Complete Surgical Repair
A prospective study of 40 patients admitted with the diagnosis of enterocutaneous fistula and prepared for definite surgical repair in the form of resection anastomosis of ECF.
- Trial name
- NCT03302598
- Testing
- serum C-reactive protein
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Pain, Postoperative, Fracture, Ankle
Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture
The purpose is to find out if incorporation of an intraoperative electro auricular acupuncture protocol when added to a standard multimodal analgesic regimen for patients undergoing surgery to repair lower leg fracture under…
- Conditions
- Pain, Postoperative, Fracture, Ankle, Pilon Fracture of Tibia, Foot Fracture
- Trial name
- NCT05984433
- Testing
- Auricular acupuncture
- Where
- United States
- Sponsor
- Baylor College of Medicine
Platelet-Rich Fibrin (PRF), Impacted Mandibular Third Molar
Salivary α-Amylase as a Non-Invasive Biomarker of PRF-Enhanced Wound Healing After Third Molar Surgery
This randomized clinical study evaluated salivary α-amylase as a non-invasive biomarker of early wound healing after mandibular third molar surgery.
- Conditions
- Platelet-Rich Fibrin (PRF), Impacted Mandibular Third Molar, Postoperative Wound Healing, Salivary Alpha Amylase
- Trial name
- NCT07600619
- Testing
- PRF group
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Hasanuddin University
Probiotics, Tooth, Impacted
Probiotics for Improving Post-surgical Healing
A randomized, double-blind, placebo-controlled clinical trial will be performed to assess the efficacy of a probiotic containing Lactobacillus reuteri in improving post-surgical wound healing after impacted tooth extractions.
- Conditions
- Probiotics, Tooth, Impacted, Wound Heal, Gastrointestinal Complication
- Trial name
- NCT04903925
- Testing
- Impacted tooth extraction
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Pisa
Sepsis, Burn Injury
TDAP in Burn Patients (Group 2)
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07223684
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Gingival Pigmentation
Nano Silver Effect in Rapid Wound Healing
Silver compounds have demonstrated a positive effect in most medical fields, including periodontal therapy, particularly in their nano-formulations.
- Trial name
- NCT07521176
- Testing
- Nano Silver Dressing, Non eugenol zinc oxide Dressing
- Where
- Syria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Damascus University
Meningomyelocele
Stress-associated Epigenetic Alterations in Newborns After Fetal Surgery
Open spina bifida or myelomeningocele (MMC) is a devastating congenital defect of the central nervous system for which there is no cure. The etiology of MMC remains poorly understood.
- Trial name
- NCT04027374
- Testing
- Fetal surgery for MMC repair
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Wound Infection
Dexamethasone and Wound Healing After Thyroid Surgery
Dexamethasone is a potent glucocorticoid with analgesic and anti-emetic effects [1-3]. Perioperative single-dose dexamethasone therapy has been used for several purposes: to reduce post-operative nausea and vomiting (PONV), pain…
- Trial name
- NCT02304250
- Testing
- Dexamethasone, saline
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Quanhong Zhou
Inguinal Hernia
PRO-RSTAP: Effect of TAP and RS Blocks on Recovery After Inguinal Hernia Surgery (PRO-RSTAP)
Inguinal hernia repair is a common surgical procedure, often performed as day-case surgery. Despite standardized surgical techniques, postoperative pain may delay recovery and occasionally lead to unplanned hospital admission.
- Trial name
- PRO-RSTAP (NCT07423910)
- Testing
- Transversus abdominis plane block (TAP block), Rectus sheath block (active), Ropivacaine
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
Mandible; Deformity, Surgical Healing
LLLT Effects on Inferior Alveolar Nerve (IAN) Recovery Post-orthognathic Surgery
Low-level laser therapy (LLLT) is a well-studied technique that has been shown to improve recovery time and reduce pain and swelling in patients undergoing surgery, including orthognathic surgery, and has no known negative…
- Conditions
- Mandible; Deformity, Surgical Healing, Orthognathic Surgery, Nerve Injury
- Trial name
- NCT04910074
- Testing
- Low-level laser therapy, Dummy LLLT
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Atrial Fibrillation New Onset, Hemorrhage
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
- Conditions
- Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia
- Trial name
- NCT01590979
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Skin Transplantation, Skin Grafting
Lower Extremity Graft Study (LEGS): A Multicentre Randomised Controlled Trial of Negative Pressure Wound Therapy Versus Conventional Dressings for Split-thickness Skin Grafts After Lower Leg Skin Tumour Excision
The goal of this clinical trial is to compare the effect of negative pressure wound therapy (NPWT) versus traditional dressings on the incidence of transplant infection in adult patients undergoing split-thickness skin grafting…
- Conditions
- Skin Transplantation, Skin Grafting, Split Thickness Skin Graft, Negative-Pressure Wound Therapy
- Trial name
- LEGS (NCT07040683)
- Testing
- Negative Pressure Wound Therapy (NPWT), Traditional Dressing
- Where
- Sweden
- Volunteers
- 232 people
- Sponsor
- Region Skane
Postoperative Pain
Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone IR for Treatment of Acute Post-op Pain Following Elective Arthroscopic (Surgery Using a Thin Flexible Scope) Shoulder Surgery
The purpose of this study is to evaluate how tapentadol immediate release (IR) and oxycodone IR treat moderate to severe post-operative pain after elective arthroscopic shoulder surgery.
- Trial name
- NCT00814580
- Testing
- Tapentadol IR, Oxycodone IR
- Volunteers
- 382 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Healthy Volunteers (HV), Skin Irritation
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers for Future Surgical Wound Use
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-MELSAFE (NCT07707986)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez