Clinical trials: Post-surgical Wound Healing
Postoperative Pain, Cesarean Section
Effect of a Transversus Abdominis Plane Block on Wound Healing, Stress, and Immune Response After a Cesarean Delivery
The primary purpose of this study is to determine whether the addition of a TAP block to standard analgesia after the cesarean delivery will impact postoperative wound healing and attenuate postoperative stress and immune…
- Conditions
- Postoperative Pain, Cesarean Section, Wound Heal
- Trial name
- NCT05840406
- Testing
- Postoperative pain management with acetaminophen, Bilateral TAP Block with levobupivacaine, Bilateral TAP Block with levobupivacaine and dexmedetomidine
- Where
- Croatia
- Volunteers
- 105 people
- Sponsor
- University Hospital Sestre Milosrdnice
Primary Inguinal Hernia
The Effect of Preemptive Regional Anesthesia (TAP-block) on Acute and Chronic Pain After Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)
The study is devoted to the impact of preemptive regional Transversus abdominal plane block on the postoperative acute and chronic pain after elective Transabdominal preperitoneal (TAPP) inguinal hernia repair.
- Trial name
- ERA-TAPP (NCT06406959)
- Testing
- Transversus abdominal plane block (TAP block)
- Where
- Russia
- Volunteers
- 78 people
- Sponsor
- Pirogov Russian National Research Medical University
Gingival Recession
Platelet Rich Fibrin in the Treatment of Palatal Wounds
In this study it will be investigated the usefulness of Platelet-Rich Fibrin (PRF) on in the epithelialized connective tissue graft palatal donor site healing acceleration and in the patient's morbidity reduction.
- Trial name
- NCT02438046
- Testing
- Palatal wound bandage
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Anal Wound
Impact of Topical Antiadhesion Therapy on Wound Healing and Postoperative Pain After Anal Surgery
2QR-complex is a patented molecule extracted from Aloe vera barbadensis leaves that blocks the adhesion of pathogenic microbes to human epithelial cells and tissues [9].
- Trial name
- NCT04275596
- Testing
- 2QR complex
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Postoperative Pain, Hernia
A Safety and Efficacy Study of SABER®-Bupivacaine for Pain Following Hernia Repair
This is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local…
- Conditions
- Postoperative Pain, Hernia, Surgery
- Trial name
- NCT00974350
- Testing
- SABER-Bupivacaine
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 124 people
- Sponsor
- Durect
Ventral Hernia
Repair of Large Incisional Hernias - To Drain or Not to Drain Randomised Clinical Trial
The aim of this study was to perform a randomised clinical trial comparing the use of closed-suction tubular drains and progressive tension sutures in individuals with large incisional hernias subjected to onlay mesh repair to…
- Trial name
- NCT02163460
- Testing
- Drain, Progressive Tension Sutures
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do Oeste do Paraná
Mandible; Deformity, Surgical Healing
LLLT Effects on Inferior Alveolar Nerve (IAN) Recovery Post-orthognathic Surgery
Low-level laser therapy (LLLT) is a well-studied technique that has been shown to improve recovery time and reduce pain and swelling in patients undergoing surgery, including orthognathic surgery, and has no known negative…
- Conditions
- Mandible; Deformity, Surgical Healing, Orthognathic Surgery, Nerve Injury
- Trial name
- NCT04910074
- Testing
- Low-level laser therapy, Dummy LLLT
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Pediatric Postoperative Pain
Postoperative Pain After Pediatric Umbilical Hernia Repair
The purpose of this study is to compare the use of ultrasound-guided bilateral rectus sheath blocks to local infiltration of anesthetic agent in the surgical wound in a pediatric population of patients undergoing umbilical hernia…
- Trial name
- NCT01015053
- Testing
- bilateral ultrasound-guided rectus sheath block, Wound infiltration
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Rotator Cuff Tears, Rotator Cuff Injuries
Rotator Cuff Integrity and Clinical Outcomes 5 Years After Repair.
The study gives an overview of surgically treated rotator cuff injury patients in Tartu University Hospital Sports Traumatology Centre during 2013-2019 and evaluates the integrity of rotator cuff at minimum 5 years after…
- Conditions
- Rotator Cuff Tears, Rotator Cuff Injuries, Rotator Cuff Tear or Rupture, Not Specified as Traumatic
- Trial name
- NCT05988541
- Testing
- Ultrasonography imaging, American Shoulder and Elbow Surgeons (ASES) Score, The Constant-Murley score (CMS)
- Where
- Estonia
- Volunteers
- 110 people
- Sponsor
- Tartu University Hospital
Corneal Epithelial Wound
Topical Insulin Versus Autologous Serum After Corneal Surgeries
The aim of the study is to test whether use of topical insulin or autologous serum eye-drops can promote corneal epithelial healing following photorefractive keratectomy (PRK).
- Trial name
- NCT05331859
- Testing
- Insulin, autologous serum (AS), conventional
- Where
- 2 sites in Egypt
- Volunteers
- 250 people
- Sponsor
- Benha University
Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8
Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer
This phase II trial tests how well immunotherapy (toripalimab) works for reducing the risk of cancer recurrence after surgery in patients with mismatch repair deficient stage IIB, IIC, or III colon cancer.
- Conditions
- Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8, Stage IIC Colon Cancer AJCC v8, Stage III Colon Cancer AJCC v8
- Trial name
- NCT07140679
- Testing
- Biopsy Procedure, Biospecimen Collection, Colonoscopy
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Congenital Heart Disease, Congenital Heart Defect
Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters
Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Transposition of the Great Arteries
- Trial name
- NCT03469843
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Rotator Cuff Tear
Progressive Active Exercise After Surgical Rotator Cuff Repair
Shoulder disorders are extremely common, with a life-time prevalence in population of 30%. About 23% of the working population with shoulder problems are sick-listed.
- Trial name
- NCT02969135
- Testing
- Progressive early passive and active movement, Limited early passive movement
- Where
- 2 sites in Denmark
- Volunteers
- 82 people
- Sponsor
- Marius Henriksen
Surgery, Pain, Postoperative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll.
- Trial name
- CARES (NCT05722002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 8 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Meniscus Rupture, Meniscus Injury
Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy
The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces.
- Conditions
- Meniscus Rupture, Meniscus Injury, Osteoarthritis of Knee
- Trial name
- NCT07079254
- Testing
- Meniscus suture, Partial meniscectomy
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Pain, Acute, Pain, Postoperative
The Impact of Esmolol Administration on Postoperative Recovery
The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain
- Conditions
- Pain, Acute, Pain, Postoperative, Pain, Chronic Post-Surgical, Esmolol
- Trial name
- esmolol (NCT05567822)
- Testing
- Esmolol Hydrochloride, normal saline
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aretaieion University Hospital
Osteoarthritis
Bandgrip vs Traditional Sutures TJA
Total Joint Arthroplasty (TJA) has become one of the most performed elective procedures. While the results of this procedure are often consistent with high patient satisfaction and return-to-function, wound-related complications…
- Trial name
- NCT05166642
- Testing
- Bandgrip Micro-Anchor Wound Closure, Suture closure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Center for Innovation and Research Organization